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• W2885299218 abstract "ARID1A, a component of the SWI/SNF chromatin remodeling complex, is a tumor suppressor with a high frequency of inactivating mutations in many cancers. Therefore, ARID1A deficiency has been exploited therapeutically for treating cancer. Here we show that ARID1A has a synthetic lethal interaction with aurora kinase A (AURKA) in colorectal cancer (CRC) cells. Pharmacological and genetic perturbations of AURKA selectively inhibit the growth of ARID1A-deficient CRC cells. Mechanistically, ARID1A occupies the AURKA gene promoter and negatively regulates its transcription. Cells lacking ARID1A show enhanced AURKA transcription, which leads to the persistent activation of CDC25C, a key protein for G2/M transition and mitotic entry. Inhibiting AURKA activity in ARID1A-deficient cells significantly increases G2/M arrest and induces cellular multinucleation and apoptosis. This study shows a novel synthetic lethality interaction between ARID1A and AURKA and indicates that pharmacologically inhibiting the AURKA-CDC25C axis represents a novel strategy for treating CRC with ARID1A loss-of-function mutations." @default.
• W2885299218 created "2018-08-22" @default.
• W2885299218 creator A5002197687 @default.
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• W2885299218 date "2018-08-10" @default.
• W2885299218 modified "2023-10-12" @default.
• W2885299218 title "Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells" @default.
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• W2885299218 cites W2002173586 @default.
• W2885299218 cites W2002218976 @default.
• W2885299218 cites W2009726317 @default.
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• W2885299218 cites W2048122601 @default.
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• W2885299218 doi "https://doi.org/10.1038/s41467-018-05694-4" @default.
• W2885299218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6086874" @default.
• W2885299218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30097580" @default.
• W2885299218 hasPublicationYear "2018" @default.
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