Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885322795> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2885322795 endingPage "274" @default.
- W2885322795 startingPage "274" @default.
- W2885322795 abstract "Objective: The objective of this study was to detect virulence genes of Helicobacter pylori (H.pylori) cagA, babA2 and hpa in gastric biopsies from patients with different stages of gastritis by polymerase chain reaction to correlate the presence of genes with the severity of the diseases.Method: A total of 80 non repetitive gastric biopsies from antrum of the stomach were obtained from the patients and subjected to study for histological examination, unease activity, culture for H.pylori, and polymerase chain reaction studies of virulence genes cagA, babA2 and hpa.Results: The most frequent detected gene by PCR was hpa (66.7%) and followed by cagA and babA2 (61.6%) for each. There was significant association between the three genes (P=0.0001). The study of the association between the virulence gene of H.pylori and different clinical symptoms revealed significant association of dyspepsia with cagA(P=0.001) babA2 and hpa (P=0.0001), regurgitation with cagA and babA2( P=0.002),vomiting with cagA and babA2 (P=0.01, P=0.002, respectively) and nausea with cagA and babA2 (P=0.0001, P=0.03, respectively). The virulence genes were detected in gastric ulcer. The degree of inflammation in histopathological examination was also statistically significant associated with the presence of virulences genes cagA (P=0.01), babA2 (p=0.0001) and hpa (P=0.0001)The present study highlights the presence of virulence genes in H.pylori associated with gastric ulcer. The genes cagA, babA2 and hpa are prevalent among the strains affecting the patients. Moreover, these genes are associated with marked clinical and pathological severity. The genes are significantly associated with each other. Further studies are recommended to validate these findings.Keywords: Gastritis, Genotypes, H.pylori, cagA, babA2, hpa, PCR" @default.
- W2885322795 created "2018-08-22" @default.
- W2885322795 creator A5014235046 @default.
- W2885322795 creator A5055148282 @default.
- W2885322795 creator A5055464284 @default.
- W2885322795 creator A5064047585 @default.
- W2885322795 creator A5074174877 @default.
- W2885322795 creator A5080676254 @default.
- W2885322795 date "2018-08-10" @default.
- W2885322795 modified "2023-09-26" @default.
- W2885322795 title "Molecular study of <i>Helicobacter pylori</i> virulence genes <i>CagA</i>, <i>Hpa</i> and <i>BabA2</i> in Egyptian patients" @default.
- W2885322795 cites W1554671073 @default.
- W2885322795 cites W1870540513 @default.
- W2885322795 cites W2039837411 @default.
- W2885322795 cites W2042655498 @default.
- W2885322795 cites W2107195693 @default.
- W2885322795 cites W2770931934 @default.
- W2885322795 doi "https://doi.org/10.4314/ajcem.v19i4.5" @default.
- W2885322795 hasPublicationYear "2018" @default.
- W2885322795 type Work @default.
- W2885322795 sameAs 2885322795 @default.
- W2885322795 citedByCount "0" @default.
- W2885322795 crossrefType "journal-article" @default.
- W2885322795 hasAuthorship W2885322795A5014235046 @default.
- W2885322795 hasAuthorship W2885322795A5055148282 @default.
- W2885322795 hasAuthorship W2885322795A5055464284 @default.
- W2885322795 hasAuthorship W2885322795A5064047585 @default.
- W2885322795 hasAuthorship W2885322795A5074174877 @default.
- W2885322795 hasAuthorship W2885322795A5080676254 @default.
- W2885322795 hasBestOaLocation W28853227951 @default.
- W2885322795 hasConcept C104317684 @default.
- W2885322795 hasConcept C126322002 @default.
- W2885322795 hasConcept C2776409635 @default.
- W2885322795 hasConcept C2778204961 @default.
- W2885322795 hasConcept C2778677798 @default.
- W2885322795 hasConcept C2779422922 @default.
- W2885322795 hasConcept C49105822 @default.
- W2885322795 hasConcept C54355233 @default.
- W2885322795 hasConcept C60987743 @default.
- W2885322795 hasConcept C71924100 @default.
- W2885322795 hasConcept C86803240 @default.
- W2885322795 hasConcept C89423630 @default.
- W2885322795 hasConcept C90924648 @default.
- W2885322795 hasConceptScore W2885322795C104317684 @default.
- W2885322795 hasConceptScore W2885322795C126322002 @default.
- W2885322795 hasConceptScore W2885322795C2776409635 @default.
- W2885322795 hasConceptScore W2885322795C2778204961 @default.
- W2885322795 hasConceptScore W2885322795C2778677798 @default.
- W2885322795 hasConceptScore W2885322795C2779422922 @default.
- W2885322795 hasConceptScore W2885322795C49105822 @default.
- W2885322795 hasConceptScore W2885322795C54355233 @default.
- W2885322795 hasConceptScore W2885322795C60987743 @default.
- W2885322795 hasConceptScore W2885322795C71924100 @default.
- W2885322795 hasConceptScore W2885322795C86803240 @default.
- W2885322795 hasConceptScore W2885322795C89423630 @default.
- W2885322795 hasConceptScore W2885322795C90924648 @default.
- W2885322795 hasIssue "4" @default.
- W2885322795 hasLocation W28853227951 @default.
- W2885322795 hasOpenAccess W2885322795 @default.
- W2885322795 hasPrimaryLocation W28853227951 @default.
- W2885322795 hasRelatedWork W2015901593 @default.
- W2885322795 hasRelatedWork W2060355465 @default.
- W2885322795 hasRelatedWork W2117319343 @default.
- W2885322795 hasRelatedWork W2124793583 @default.
- W2885322795 hasRelatedWork W2138005716 @default.
- W2885322795 hasRelatedWork W2152462561 @default.
- W2885322795 hasRelatedWork W2260803508 @default.
- W2885322795 hasRelatedWork W2392918070 @default.
- W2885322795 hasRelatedWork W2958101559 @default.
- W2885322795 hasRelatedWork W3173841085 @default.
- W2885322795 hasVolume "19" @default.
- W2885322795 isParatext "false" @default.
- W2885322795 isRetracted "false" @default.
- W2885322795 magId "2885322795" @default.
- W2885322795 workType "article" @default.