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- W2885331289 abstract "Introduction: Cigarette smoking promotes vascular endothelial damage and accelerates progression of atherosclerosis. The purpose of this study was (1) to examine effects of smoking cessation intervention on vascular function and (2) to investigate whether circulating level of microRNA-126 (miR-126), a vascular endothelium-enriched microRNA, would recover from smoking-related endothelial damage in middle-aged habitual smokers. Methods: Middle-aged male smokers (n=30) were enrolled and instructed to stop smoking. Their clinical profiles of vascular function and laboratory findings including serum levels of cotinine, a principal metabolite of nicotine, and expression of miR-126 were investigated at baseline and 8 weeks after the instruction. Vascular function for peripheral small vessels was assessed using End-PAT 2000 and expressed as reactive hyperemia peripheral arterial tonometry (RH-PAT) index. The expression of miR-126 in plasma was analyzed by quantitative real-time PCR. Results: At baseline, serum co..." @default.
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- W2885331289 date "2014-11-25" @default.
- W2885331289 modified "2023-09-24" @default.
- W2885331289 title "Abstract 11525: Blood Pressure Reduction and Increase of Circulating MicroRNA-126 Indicate Improvement of Vascular Endothelial Damage After Smoking Cessation Intervention in Middle-Aged Habitual Smokers" @default.
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