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- W2885334001 abstract "Abstract We aim to detect the mostdifferentially expressed miRNAs in serum of Egyptian patients with chronic HCV infection before and after treatment using new treatment protocol of Sofosbuvir; pegylated interferon and ribavirin. The current study conducted on 50patientswith chronic HCV infection who received the treatment and 20 healthy controls. Array analysis revealed that, over-expression of 80 miRNAs and down-regulation of only 4miRNAs with significant different among HCV patients before treatment (over 2-fold changes). Both miR-122 and miR-221 were found to be significantly up-regulated among patients before treatment compared with control group (P = 0.04 & 0.003 respectively) and significantly down regulated in response to treatment (P = 0.02 & 0.008 respectively).In conclusion, aberrantmiRNA array especially miR-122 and miR-221could potentially extract data for HCV patients in response to combined new therapy. These findings empathizes the importance of contributing the role of miRNAsduring presence and clearance of HCV." @default.
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- W2885334001 date "2018-12-01" @default.
- W2885334001 modified "2023-09-27" @default.
- W2885334001 title "Assessment of serum level of MiRNAs before and after treatment with sofosbuvir in Egyptian patients with chronic HCV infection" @default.
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- W2885334001 doi "https://doi.org/10.1016/j.mgene.2018.08.005" @default.
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