FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885339992> ?p ?o ?g. }

• W2885339992 endingPage "309" @default.
• W2885339992 startingPage "302" @default.
• W2885339992 abstract "PURPOSE OF THE STUDYProsthetic joint infection (PJI) is a feared complication of total joint arthroplasty. Several strategies have been developed to it. The purpose of our study was to compare therapeutic strategies for PJI treatment published in the literature.MATERIAL AND METHODSWe retrieved around 5,000 documents concerning this topic, published between January 1960 and November 2006, from the databases MEDLINE and EMBASE. Using a two-phase selection, 382 relevant articles were chosen, and full texts were obtained for 302 of them (79%). However, only 77 of them fulfilled the criteria for inclusion in our study. A total of 645 hips and 1,145 knees could be analyzed. A comparison was made of the following procedures: two-stage surgery, one-stage surgery, implant removal and long-term antibiotic therapy in hip PJI; two-stage surgery, debridement, arthrodesis and long-term antibiotic therapy in knee PJI. The criteria used to evaluate successful PJI treatment included the rate of recurrent infection (primary outcome) and the rate of additional surgery (secondary outcome). The capability index (c), relative risk (RR), odds ratio and number needed to treat (NNT) were calculated for both outcomes under study.RESULTS1. The lowest rate of recurrent PJI was reported for two-stage reimplantation (hips, 7.4%; knees, 11%), then came one-stage reimplantation for hip PJI (9.2%) and arthrodesis for knee PJI (15.6%).2. The lowest relative risk for the primary outcome of this study was found in two-stage reimplantation (RR=0.62 and 0.32 for hip and knee PJI, respectively, knee arthrodesis (RR=0.78) and one-stage hip reimplantation (RR=1.07).3. The NNT was negative for two-stage reimplantation (NNT = -21.6 and -4.3 for hip and knee PJI, respectively).4. Compared to long-term antibiotic therapy, knee debridement had a higher risk of recurrent infection (RR, 4.72 versus 1.20) as well as the risk of additional surgery (RR, 4.41 versus 1.31). However, when the capability index and NNT were used, knee debridement achieved better primary outcomes than antibiotic therapy (c=0.0317 versus 0.0000) and NNT (2.2 versus 26.3).5. Relative risk for additional surgery was the lowest in two-stage reimplantation (RR=0.47 and 0.36 for hip and knee PJI, respectively), and the highest in long-term antibiotic therapy for hip PJI (RR=6.47).DISCUSSIONThe resultant ranking of therapeutic approaches to PJI, as found in our study, is not surprising; except for seemingly better outcomes achieved by long-term antibiotic therapy compared to surgical debridement in knee PJI. This, among others, shows the need to use more comprehensible statistical instruments, such as the capability index, that could provide a more reliable evaluation of therapeutic interventions.CONCLUSIONSA two-stage protocol for PJI treatment had the lowest risk for both PJI recurrence and need for additional surgery in comparison with all other strategies developed for PJI therapy. Therefore, it should be accepted as the method of choice. One-stage hip reimplantation is a less reliable approach in which it is inevitable to strictly respect the indication criteria. Other methods are either less reliable or associated with a high risk of repeat surgeries, or provide functionally unacceptable outcomes." @default.
• W2885339992 created "2018-08-22" @default.
• W2885339992 creator A5017790545 @default.
• W2885339992 creator A5028952849 @default.
• W2885339992 creator A5054541128 @default.
• W2885339992 creator A5054831892 @default.
• W2885339992 date "2009-08-01" @default.
• W2885339992 modified "2023-09-26" @default.
• W2885339992 title "Porovnání léčebných postupů používaných v terapii infekce kloubních náhrad kyčle a kolena" @default.
• W2885339992 hasPublicationYear "2009" @default.
• W2885339992 type Work @default.
• W2885339992 sameAs 2885339992 @default.
• W2885339992 citedByCount "0" @default.
• W2885339992 crossrefType "journal-article" @default.
• W2885339992 hasAuthorship W2885339992A5017790545 @default.
• W2885339992 hasAuthorship W2885339992A5028952849 @default.
• W2885339992 hasAuthorship W2885339992A5054541128 @default.
• W2885339992 hasAuthorship W2885339992A5054831892 @default.
• W2885339992 hasConcept C126322002 @default.
• W2885339992 hasConcept C141071460 @default.
• W2885339992 hasConcept C142724271 @default.
• W2885339992 hasConcept C146357865 @default.
• W2885339992 hasConcept C151730666 @default.
• W2885339992 hasConcept C156957248 @default.
• W2885339992 hasConcept C204787440 @default.
• W2885339992 hasConcept C2778120723 @default.
• W2885339992 hasConcept C2778336525 @default.
• W2885339992 hasConcept C2781298600 @default.
• W2885339992 hasConcept C44249647 @default.
• W2885339992 hasConcept C68312169 @default.
• W2885339992 hasConcept C71924100 @default.
• W2885339992 hasConcept C82789193 @default.
• W2885339992 hasConcept C86803240 @default.
• W2885339992 hasConceptScore W2885339992C126322002 @default.
• W2885339992 hasConceptScore W2885339992C141071460 @default.
• W2885339992 hasConceptScore W2885339992C142724271 @default.
• W2885339992 hasConceptScore W2885339992C146357865 @default.
• W2885339992 hasConceptScore W2885339992C151730666 @default.
• W2885339992 hasConceptScore W2885339992C156957248 @default.
• W2885339992 hasConceptScore W2885339992C204787440 @default.
• W2885339992 hasConceptScore W2885339992C2778120723 @default.
• W2885339992 hasConceptScore W2885339992C2778336525 @default.
• W2885339992 hasConceptScore W2885339992C2781298600 @default.
• W2885339992 hasConceptScore W2885339992C44249647 @default.
• W2885339992 hasConceptScore W2885339992C68312169 @default.
• W2885339992 hasConceptScore W2885339992C71924100 @default.
• W2885339992 hasConceptScore W2885339992C82789193 @default.
• W2885339992 hasConceptScore W2885339992C86803240 @default.
• W2885339992 hasIssue "4" @default.
• W2885339992 hasLocation W28853399921 @default.
• W2885339992 hasOpenAccess W2885339992 @default.
• W2885339992 hasPrimaryLocation W28853399921 @default.
• W2885339992 hasVolume "76" @default.
• W2885339992 isParatext "false" @default.
• W2885339992 isRetracted "false" @default.
• W2885339992 magId "2885339992" @default.
• W2885339992 workType "article" @default.