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- W288534263 abstract "Diffuse axonal injury is thought to be the basis of the functional impairments stemming from mild traumatic brain injury. To examine how axons are damaged by traumatic events, such as motor vehicle accidents, falls, sports activities, or explosive blasts, we have taken advantage of the spinal cord with its extensive white matter tracts. We developed a closed-body model of spinal cord injury in mice whereby high-pressure air blasts targeted to lower thoracic vertebral levels produce tensile, compressive, and shear forces within the parenchyma of the spinal cord and thereby cause extensive axonal injury. Markers of cytoskeletal integrity showed that spinal cord axons exhibited three distinct pathologies: microtubule breakage, neurofilament compaction, and calpain-mediated spectrin breakdown. The dorsally situated axons of the corticospinal tract primarily exhibited microtubule breakage, whereas all three pathologies were common in the lateral and ventral white matter. Individual axons typically demonstrated only one of the three pathologies during the first 24 h after blast injury, suggesting that the different perturbations are initiated independently of one another. For the first few days after blast, neurofilament compaction was frequently accompanied by autophagy, and subsequent to that, by the fragmentation of degenerating axons. TuJ1 immunolabeling and mice with YFP-reporter labeling each revealed more extensive microtubule breakage than did βAPP immunolabeling, raising doubts about the sensitivity of this standard approach for assessing axonal injury. Although motor deficits were mild and largely transient, some aspects of motor function gradually worsened over several weeks, suggesting that a low level of axonal degeneration continued past the initial wave. Our model can help provide further insight into how to intervene in the processes by which initial axonal damage culminates in axonal degeneration, to improve outcomes after traumatic injury. Importantly, our findings of extensive axonal injury also caution that repeated trauma is likely to have cumulative adverse consequences for both brain and spinal cord." @default.
- W288534263 created "2016-06-24" @default.
- W288534263 creator A5006335802 @default.
- W288534263 creator A5031863637 @default.
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- W288534263 creator A5062762931 @default.
- W288534263 creator A5081305115 @default.
- W288534263 creator A5083673070 @default.
- W288534263 date "2015-09-01" @default.
- W288534263 modified "2023-10-17" @default.
- W288534263 title "A novel closed-body model of spinal cord injury caused by high-pressure air blasts produces extensive axonal injury and motor impairments" @default.
- W288534263 cites W1580653784 @default.
- W288534263 cites W1954155767 @default.
- W288534263 cites W1968586481 @default.
- W288534263 cites W1968961400 @default.
- W288534263 cites W1972105383 @default.
- W288534263 cites W1972889453 @default.
- W288534263 cites W1975824688 @default.
- W288534263 cites W1976157383 @default.
- W288534263 cites W1977046646 @default.
- W288534263 cites W1978713741 @default.
- W288534263 cites W1979434326 @default.
- W288534263 cites W1983325630 @default.
- W288534263 cites W1983455034 @default.
- W288534263 cites W1990486050 @default.
- W288534263 cites W1993426725 @default.
- W288534263 cites W1994314634 @default.
- W288534263 cites W1994824032 @default.
- W288534263 cites W1995190455 @default.
- W288534263 cites W2000061726 @default.
- W288534263 cites W2001216342 @default.
- W288534263 cites W2001793734 @default.
- W288534263 cites W2002120184 @default.
- W288534263 cites W2003719026 @default.
- W288534263 cites W2005249858 @default.
- W288534263 cites W2005746911 @default.
- W288534263 cites W2006574262 @default.
- W288534263 cites W2006875006 @default.
- W288534263 cites W2007038178 @default.
- W288534263 cites W2007743087 @default.
- W288534263 cites W2009178440 @default.
- W288534263 cites W2012664119 @default.
- W288534263 cites W2012928251 @default.
- W288534263 cites W2014154241 @default.
- W288534263 cites W2014573802 @default.
- W288534263 cites W2015231013 @default.
- W288534263 cites W2016108891 @default.
- W288534263 cites W2020723464 @default.
- W288534263 cites W2021518416 @default.
- W288534263 cites W2025751621 @default.
- W288534263 cites W2025935987 @default.
- W288534263 cites W2027047440 @default.
- W288534263 cites W2034894932 @default.
- W288534263 cites W2034936533 @default.
- W288534263 cites W2036212782 @default.
- W288534263 cites W2039067866 @default.
- W288534263 cites W2040312236 @default.
- W288534263 cites W2041026258 @default.
- W288534263 cites W2047754178 @default.
- W288534263 cites W2048385267 @default.
- W288534263 cites W2051549180 @default.
- W288534263 cites W2053678016 @default.
- W288534263 cites W205693250 @default.
- W288534263 cites W2057524647 @default.
- W288534263 cites W2059855262 @default.
- W288534263 cites W2060108012 @default.
- W288534263 cites W2061812167 @default.
- W288534263 cites W2063973660 @default.
- W288534263 cites W2065149815 @default.
- W288534263 cites W2066475745 @default.
- W288534263 cites W2069359956 @default.
- W288534263 cites W2069765505 @default.
- W288534263 cites W2070860839 @default.
- W288534263 cites W2071425128 @default.
- W288534263 cites W2076034347 @default.
- W288534263 cites W2076492394 @default.
- W288534263 cites W2081325915 @default.
- W288534263 cites W2084110692 @default.
- W288534263 cites W2087779448 @default.
- W288534263 cites W2088637934 @default.
- W288534263 cites W2088800239 @default.
- W288534263 cites W2088874837 @default.
- W288534263 cites W2089544324 @default.
- W288534263 cites W2094008621 @default.
- W288534263 cites W2103044571 @default.
- W288534263 cites W2106837589 @default.
- W288534263 cites W2109176718 @default.
- W288534263 cites W2112238516 @default.
- W288534263 cites W2113505916 @default.
- W288534263 cites W2116838881 @default.
- W288534263 cites W2118765707 @default.
- W288534263 cites W2129169937 @default.
- W288534263 cites W2134478490 @default.
- W288534263 cites W2136882542 @default.
- W288534263 cites W2137938185 @default.
- W288534263 cites W2140858663 @default.
- W288534263 cites W2141679195 @default.
- W288534263 cites W2142358695 @default.