FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885360033> ?p ?o ?g. }

• W2885360033 endingPage "119" @default.
• W2885360033 startingPage "113" @default.
• W2885360033 abstract "There is the first evidence of changes in the kinetics of B cell antigen receptor (BCR) internalisation of neoplastic cells in chronic lymphocytic leukemia (CLL) after the short-term and long-term administration of ibrutinib. We aimed to assess the influence of short-term and long-term ibrutinib treatment on the HLA-DR expression on CLL cells, T cells and monocytes. The immunophenotyping of CLL and immune cells in peripheral blood was performed on 16 high-risk CLL patients treated with ibrutinib. After early ibrutinib administration, the HLA-DR expression on CLL cells reduced (P = 0.032), accompanied by an increase in CLL cell counts in peripheral blood (P = 0.001). In vitro culturing of CLL cells with ibrutinib also revealed the reduction in the HLA-DR expression at protein and mRNA levels (P < 0.01). The decrease in HLA-DR on CLL cells after the first month was followed by the gradual increase of its expression by the 12th month (P = 0.001). A one-month follow-up resulted in elevated absolute counts of CD4+ (P = 0.002) and CD8+ (P < 0.001) T cells as well as CD4+ and CD8+ cells bearing HLA-DR (P < 0.01). The long-term administration of ibrutinib was associated with the increased numbers of CD4+ bearing HLA-DR (P = 0.006) and elevation of HLA-DR expression on all monocyte subsets (P ≤ 0.004). Our results provide the first evidence of the time-dependent immunomodulatory effect of ibrutinib on CLL and T cells and monocytes. The clinical consequences of time-dependent changes in HLA-DR expression in ibrutinib treated patients deserve further investigation." @default.
• W2885360033 created "2018-08-22" @default.
• W2885360033 creator A5013247889 @default.
• W2885360033 creator A5016480427 @default.
• W2885360033 creator A5023239518 @default.
• W2885360033 creator A5035577625 @default.
• W2885360033 creator A5041569532 @default.
• W2885360033 creator A5056523918 @default.
• W2885360033 creator A5059489813 @default.
• W2885360033 creator A5075931039 @default.
• W2885360033 creator A5076559458 @default.
• W2885360033 creator A5085858767 @default.
• W2885360033 date "2018-09-01" @default.
• W2885360033 modified "2023-10-02" @default.
• W2885360033 title "Dynamic changes in HLA-DR expression during short-term and long-term ibrutinib treatment in patients with chronic lymphocytic leukemia" @default.
• W2885360033 cites W1712566393 @default.
• W2885360033 cites W1969953749 @default.
• W2885360033 cites W1984916304 @default.
• W2885360033 cites W1990986028 @default.
• W2885360033 cites W1993538457 @default.
• W2885360033 cites W2011950935 @default.
• W2885360033 cites W2018571395 @default.
• W2885360033 cites W2024450923 @default.
• W2885360033 cites W2025080754 @default.
• W2885360033 cites W2027915986 @default.
• W2885360033 cites W2033702269 @default.
• W2885360033 cites W2035976164 @default.
• W2885360033 cites W2050161362 @default.
• W2885360033 cites W2065338378 @default.
• W2885360033 cites W2071549499 @default.
• W2885360033 cites W2078493126 @default.
• W2885360033 cites W2089103836 @default.
• W2885360033 cites W2108965452 @default.
• W2885360033 cites W2113170542 @default.
• W2885360033 cites W2138397823 @default.
• W2885360033 cites W2142099365 @default.
• W2885360033 cites W2145607980 @default.
• W2885360033 cites W2152498148 @default.
• W2885360033 cites W2164323857 @default.
• W2885360033 cites W2165957370 @default.
• W2885360033 cites W2171771895 @default.
• W2885360033 cites W2172718055 @default.
• W2885360033 cites W2195033221 @default.
• W2885360033 cites W2264345925 @default.
• W2885360033 cites W2318161370 @default.
• W2885360033 cites W2482579995 @default.
• W2885360033 cites W2512575699 @default.
• W2885360033 cites W2533718237 @default.
• W2885360033 cites W2600632111 @default.
• W2885360033 cites W2624411770 @default.
• W2885360033 cites W2734526350 @default.
• W2885360033 cites W2735193038 @default.
• W2885360033 cites W2745217803 @default.
• W2885360033 cites W2766697888 @default.
• W2885360033 cites W2775157068 @default.
• W2885360033 doi "https://doi.org/10.1016/j.leukres.2018.08.006" @default.
• W2885360033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30149317" @default.
• W2885360033 hasPublicationYear "2018" @default.
• W2885360033 type Work @default.
• W2885360033 sameAs 2885360033 @default.
• W2885360033 citedByCount "7" @default.
• W2885360033 countsByYear W28853600332020 @default.
• W2885360033 countsByYear W28853600332021 @default.
• W2885360033 countsByYear W28853600332022 @default.
• W2885360033 countsByYear W28853600332023 @default.
• W2885360033 crossrefType "journal-article" @default.
• W2885360033 hasAuthorship W2885360033A5013247889 @default.
• W2885360033 hasAuthorship W2885360033A5016480427 @default.
• W2885360033 hasAuthorship W2885360033A5023239518 @default.
• W2885360033 hasAuthorship W2885360033A5035577625 @default.
• W2885360033 hasAuthorship W2885360033A5041569532 @default.
• W2885360033 hasAuthorship W2885360033A5056523918 @default.
• W2885360033 hasAuthorship W2885360033A5059489813 @default.
• W2885360033 hasAuthorship W2885360033A5075931039 @default.
• W2885360033 hasAuthorship W2885360033A5076559458 @default.
• W2885360033 hasAuthorship W2885360033A5085858767 @default.
• W2885360033 hasConcept C126322002 @default.
• W2885360033 hasConcept C167672396 @default.
• W2885360033 hasConcept C170493617 @default.
• W2885360033 hasConcept C196166836 @default.
• W2885360033 hasConcept C203014093 @default.
• W2885360033 hasConcept C2776090121 @default.
• W2885360033 hasConcept C2777938653 @default.
• W2885360033 hasConcept C2778461978 @default.
• W2885360033 hasConcept C2779878957 @default.
• W2885360033 hasConcept C42362537 @default.
• W2885360033 hasConcept C502942594 @default.
• W2885360033 hasConcept C553184892 @default.
• W2885360033 hasConcept C71924100 @default.
• W2885360033 hasConcept C8891405 @default.
• W2885360033 hasConcept C90059517 @default.
• W2885360033 hasConceptScore W2885360033C126322002 @default.
• W2885360033 hasConceptScore W2885360033C167672396 @default.
• W2885360033 hasConceptScore W2885360033C170493617 @default.
• W2885360033 hasConceptScore W2885360033C196166836 @default.
• W2885360033 hasConceptScore W2885360033C203014093 @default.
• W2885360033 hasConceptScore W2885360033C2776090121 @default.
• W2885360033 hasConceptScore W2885360033C2777938653 @default.

• next