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• W2885361524 abstract "Abstract The cerebellum integrates descending motor commands and sensory information to generate predictions and detect errors during ongoing behaviors. Cerebellar computation has been proposed to control motor but also non-motor behaviors, including reward expectation and cognitive flexibility. However, the organization and functional contribution of cerebellar output channels are incompletely understood. Here, we elaborate the cell-type specificity of a broad connectivity matrix from the deep cerebellar nuclei (DCN) to the dorsal striatum in mice. Cerebello-striatal connections arise from all deep cerebellar subnuclei and are relayed through intralaminar thalamic nuclei (ILN). In the dorsal striatum, these connections target medium spiny neurons, but also ChAT-positive interneurons, a class of tonically active interneurons implicated in shifting and updating behavioral strategies. Chemogenetic silencing of cerebello-striatal connectivity modifies function of striatal ChAT-positive interneurons. We propose that cerebello-striatal connections relay cerebellar computation to striatal circuits for goal-directed behaviors." @default.
• W2885361524 created "2018-08-22" @default.
• W2885361524 creator A5003447475 @default.
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• W2885361524 date "2018-08-07" @default.
• W2885361524 modified "2023-10-12" @default.
• W2885361524 title "Regulation of striatal cells and goal-directed behavior by cerebellar outputs" @default.
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• W2885361524 doi "https://doi.org/10.1038/s41467-018-05565-y" @default.
• W2885361524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6081479" @default.
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