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• W2885363206 abstract "Arterial pressure or flow wave propagation velocity (pulse wave velocity [PWV]) is inherently dependent on arterial elastic characteristics and distending pressure. Assessment of instantaneous variation in PWV over the cardiac cycle can be noninvasively performed using established biomechanical models by measuring arterial pressure and diameter from the same site. In this work, we explore and validate the viability of a bi-modal probe for local evaluation of PWV variation over the cardiac cycle as a function of arterial pressure. The proposed probe employs singleelement ultrasound transducer (for diameter measurement) and tonometric sensor (for pressure measurement) integrated into a custom probe holder. An application-specific measurement system and dedicated algorithms were used for simultaneous assessment of the desired physiological waveforms. The optimized transducer arrangement in the proposed probe allowed reliable capture of high-fidelity pressure and diameter waveforms from a single arterial site. Real-time assessment of variation in local PWV as a function of arterial pressure was validated on 10 human subjects (age = 31 ± 6 years) using the developed prototype system. Local PWV was found to increase during the systolic phase of each cardiac cycle, and exhibits a non-linear relationship with the arterial pressure. Results from the performed pilot study demonstrated that the proposed ultrasound-tonometer based onepoint method could reliably capture the incremental local PWV over continuous cardiac cycles. Simultaneous assessment of instantaneous variation in arterial pressure, diameter and local PWV using the proposed bi-modal probe has the potential to accurately characterize the elastic behavior of arteries." @default.
• W2885363206 created "2018-08-22" @default.
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• W2885363206 date "2018-06-01" @default.
• W2885363206 modified "2023-10-11" @default.
• W2885363206 title "Non-Invasive Assessment of Local Pulse Wave Velocity as Function of Arterial Pressure" @default.
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• W2885363206 doi "https://doi.org/10.1109/memea.2018.8438763" @default.
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