FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885363368> ?p ?o ?g. }

• W2885363368 endingPage "e0201851" @default.
• W2885363368 startingPage "e0201851" @default.
• W2885363368 abstract "Rheumatoid arthritis (RA) is an autoimmune disease that causes the chronic inflammation of the joints. Intercellular communication containing synovial fibroblasts seems to play a major role in RA pathogenesis. In this study, to better understand intercellular communication related to RA pathogenesis, we identified exosomal microRNAs (miRNAs) derived from synovial fibroblasts. Exosomes were collected from an RA synovial fibroblast (RASF) cell line, namely, MH7A, with or without stimulation by tumor necrosis factor alpha (TNF-α). We used small RNA sequencing to analyze the profile of small RNAs, including miRNAs, in MH7A exosomes and cells. By using differential expression analysis, we identified four miRNAs (miR-155-5p, miR-146a-5p, miR-323a-5p, and miR-1307-3p) that are upregulated in exosomes with TNF-α stimulation. The identification of miR-155-5p and miR-146a-5p which have been reported in RA patients demonstrated the validity of our experimental model. Other two miRNAs were newly identified. miR-323a-5p was predicted to target the protein encoding gene CD6, which attenuates T-cell activation signals, and miR-1307-3p was predicted to target the protein encoding gene N-myc downstream-regulated gene 2 (NDRG2), which inhibits osteoclast-related gene expression. The results suggested that these miRNAs might be involved in RA pathogenesis. We hope our results will help us understand the role of RASF exosomes in RA pathogenesis." @default.
• W2885363368 created "2018-08-22" @default.
• W2885363368 creator A5026647308 @default.
• W2885363368 creator A5030247163 @default.
• W2885363368 creator A5037515673 @default.
• W2885363368 creator A5066036279 @default.
• W2885363368 date "2018-08-10" @default.
• W2885363368 modified "2023-09-23" @default.
• W2885363368 title "Small RNAs detected in exosomes derived from the MH7A synovial fibroblast cell line with TNF-α stimulation" @default.
• W2885363368 cites W1533291299 @default.
• W2885363368 cites W1543137167 @default.
• W2885363368 cites W1631781682 @default.
• W2885363368 cites W1877686344 @default.
• W2885363368 cites W1966054625 @default.
• W2885363368 cites W1974035668 @default.
• W2885363368 cites W1974976948 @default.
• W2885363368 cites W1979206745 @default.
• W2885363368 cites W1984683661 @default.
• W2885363368 cites W1985207716 @default.
• W2885363368 cites W1985844219 @default.
• W2885363368 cites W1988140132 @default.
• W2885363368 cites W1993165035 @default.
• W2885363368 cites W1996639668 @default.
• W2885363368 cites W1999925406 @default.
• W2885363368 cites W2015387324 @default.
• W2885363368 cites W2025199750 @default.
• W2885363368 cites W2025207265 @default.
• W2885363368 cites W2028006609 @default.
• W2885363368 cites W2028566550 @default.
• W2885363368 cites W2032735323 @default.
• W2885363368 cites W2034722418 @default.
• W2885363368 cites W2036897871 @default.
• W2885363368 cites W2047960154 @default.
• W2885363368 cites W2057419005 @default.
• W2885363368 cites W2059695215 @default.
• W2885363368 cites W2060133690 @default.
• W2885363368 cites W2060660496 @default.
• W2885363368 cites W2060921614 @default.
• W2885363368 cites W2062706858 @default.
• W2885363368 cites W2064786601 @default.
• W2885363368 cites W2070011436 @default.
• W2885363368 cites W2075860675 @default.
• W2885363368 cites W2077327925 @default.
• W2885363368 cites W2079543912 @default.
• W2885363368 cites W2083381199 @default.
• W2885363368 cites W2099540110 @default.
• W2885363368 cites W2107018762 @default.
• W2885363368 cites W2108234281 @default.
• W2885363368 cites W2110826367 @default.
• W2885363368 cites W2114104545 @default.
• W2885363368 cites W2116268000 @default.
• W2885363368 cites W2119043140 @default.
• W2885363368 cites W2124925707 @default.
• W2885363368 cites W2124985265 @default.
• W2885363368 cites W2127669794 @default.
• W2885363368 cites W2128384671 @default.
• W2885363368 cites W2128674168 @default.
• W2885363368 cites W2130116522 @default.
• W2885363368 cites W2130941135 @default.
• W2885363368 cites W2132226013 @default.
• W2885363368 cites W2133571578 @default.
• W2885363368 cites W2134019217 @default.
• W2885363368 cites W2140102579 @default.
• W2885363368 cites W2140861987 @default.
• W2885363368 cites W2141425631 @default.
• W2885363368 cites W2141599418 @default.
• W2885363368 cites W2157586673 @default.
• W2885363368 cites W2157686531 @default.
• W2885363368 cites W2158714788 @default.
• W2885363368 cites W2159060882 @default.
• W2885363368 cites W2168173728 @default.
• W2885363368 cites W2170852633 @default.
• W2885363368 cites W2171398108 @default.
• W2885363368 cites W2291999923 @default.
• W2885363368 cites W2318433546 @default.
• W2885363368 cites W2343186061 @default.
• W2885363368 cites W2468459975 @default.
• W2885363368 cites W2558513068 @default.
• W2885363368 cites W2565271826 @default.
• W2885363368 cites W2587206126 @default.
• W2885363368 cites W2622590282 @default.
• W2885363368 cites W2739501186 @default.
• W2885363368 cites W2768241957 @default.
• W2885363368 cites W2786514708 @default.
• W2885363368 cites W4210968471 @default.
• W2885363368 cites W4250359879 @default.
• W2885363368 cites W748047530 @default.
• W2885363368 doi "https://doi.org/10.1371/journal.pone.0201851" @default.
• W2885363368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6086399" @default.
• W2885363368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30096164" @default.
• W2885363368 hasPublicationYear "2018" @default.
• W2885363368 type Work @default.
• W2885363368 sameAs 2885363368 @default.
• W2885363368 citedByCount "19" @default.
• W2885363368 countsByYear W28853633682019 @default.
• W2885363368 countsByYear W28853633682020 @default.
• W2885363368 countsByYear W28853633682021 @default.
• W2885363368 countsByYear W28853633682022 @default.

• next