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- W2885373639 endingPage "49" @default.
- W2885373639 startingPage "37" @default.
- W2885373639 abstract "Introduction: Heart failure (HF) is an important public health problem with an increasing prevalence across the globe. The mortality rates from this complex clinical problem have stabilized in the recent years with the use of pharmacotherapeutics which demonstrated survival benefits in patients with HF with reduced ejection fraction (HFrEF).Areas covered: We reviewed the seven classes of medications which constitute the guideline-directed medical therapy (GDMT) in chronic HF patients. We discussed clinical trials which support or contradict their use, potential adverse events, and available real-world data on utilization and safety.Expert opinion: Loop diuretics form a major component of baseline therapy in HF patients to maintain euvolemia. As diastolic HF is more volume sensitive then systolic HF, diuretic use should be judiciously monitored to prevent states of volume depletion and associated complications. Neurohormonal modulation with pharmacotherapies are efficacious in reducing morbidity and mortality in the chronic HFrEF population. However, registry data showed that treatment intolerance and adverse events result in lower prescription rates of GDMT. Sacubitril/valsartan represents a major therapeutic advance in the treatment of HFrEF patients and can be safely used in addition to other GDMTs. Therapies to improve outcomes in diastolic HF patients are needed." @default.
- W2885373639 created "2018-08-22" @default.
- W2885373639 creator A5014064578 @default.
- W2885373639 creator A5064962663 @default.
- W2885373639 creator A5091070572 @default.
- W2885373639 date "2018-08-31" @default.
- W2885373639 modified "2023-09-25" @default.
- W2885373639 title "Benefit–risk review of different drug classes used in chronic heart failure" @default.
- W2885373639 cites W1546227773 @default.
- W2885373639 cites W1552651080 @default.
- W2885373639 cites W1604138739 @default.
- W2885373639 cites W1654241318 @default.
- W2885373639 cites W1697884774 @default.
- W2885373639 cites W1880552130 @default.
- W2885373639 cites W1932115126 @default.
- W2885373639 cites W1966294459 @default.
- W2885373639 cites W1966637711 @default.
- W2885373639 cites W1968782440 @default.
- W2885373639 cites W1972592757 @default.
- W2885373639 cites W197537298 @default.
- W2885373639 cites W1981731045 @default.
- W2885373639 cites W1983259461 @default.
- W2885373639 cites W1984421771 @default.
- W2885373639 cites W1987093417 @default.
- W2885373639 cites W1987226346 @default.
- W2885373639 cites W1988897145 @default.
- W2885373639 cites W1993563395 @default.
- W2885373639 cites W1994035387 @default.
- W2885373639 cites W1997249895 @default.
- W2885373639 cites W2000114233 @default.
- W2885373639 cites W2000335872 @default.
- W2885373639 cites W2001323802 @default.
- W2885373639 cites W2001468869 @default.
- W2885373639 cites W2006254974 @default.
- W2885373639 cites W2010396034 @default.
- W2885373639 cites W2018573712 @default.
- W2885373639 cites W2033565692 @default.
- W2885373639 cites W2039665384 @default.
- W2885373639 cites W2042121431 @default.
- W2885373639 cites W2045247934 @default.
- W2885373639 cites W2046173195 @default.
- W2885373639 cites W2046383587 @default.
- W2885373639 cites W2054109122 @default.
- W2885373639 cites W2056893352 @default.
- W2885373639 cites W2058860004 @default.
- W2885373639 cites W2059402235 @default.
- W2885373639 cites W2068519950 @default.
- W2885373639 cites W2071837142 @default.
- W2885373639 cites W2073274738 @default.
- W2885373639 cites W2075380397 @default.
- W2885373639 cites W2076008670 @default.
- W2885373639 cites W2084135745 @default.
- W2885373639 cites W2097123331 @default.
- W2885373639 cites W2098767714 @default.
- W2885373639 cites W2098780362 @default.
- W2885373639 cites W2100328282 @default.
- W2885373639 cites W2103270648 @default.
- W2885373639 cites W2104209472 @default.
- W2885373639 cites W2106493153 @default.
- W2885373639 cites W2106960442 @default.
- W2885373639 cites W2113698123 @default.
- W2885373639 cites W2113829060 @default.
- W2885373639 cites W2119493017 @default.
- W2885373639 cites W2121193039 @default.
- W2885373639 cites W2122290203 @default.
- W2885373639 cites W2126896570 @default.
- W2885373639 cites W2127254785 @default.
- W2885373639 cites W2127416277 @default.
- W2885373639 cites W2131211719 @default.
- W2885373639 cites W2133970085 @default.
- W2885373639 cites W2134617609 @default.
- W2885373639 cites W2134726862 @default.
- W2885373639 cites W2136642260 @default.
- W2885373639 cites W2140023412 @default.
- W2885373639 cites W2143094666 @default.
- W2885373639 cites W2146897448 @default.
- W2885373639 cites W2149495528 @default.
- W2885373639 cites W2152072062 @default.
- W2885373639 cites W2154143064 @default.
- W2885373639 cites W2154370947 @default.
- W2885373639 cites W2157973908 @default.
- W2885373639 cites W2159461724 @default.
- W2885373639 cites W2160520202 @default.
- W2885373639 cites W2164705414 @default.
- W2885373639 cites W2165735403 @default.
- W2885373639 cites W2165928467 @default.
- W2885373639 cites W2167531137 @default.
- W2885373639 cites W2167760816 @default.
- W2885373639 cites W2172025889 @default.
- W2885373639 cites W2178738676 @default.
- W2885373639 cites W2202979518 @default.
- W2885373639 cites W2296998040 @default.
- W2885373639 cites W2323458614 @default.
- W2885373639 cites W2333113037 @default.
- W2885373639 cites W2338262993 @default.
- W2885373639 cites W2345492546 @default.
- W2885373639 cites W2404259684 @default.
- W2885373639 cites W2427094903 @default.