FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885382697> ?p ?o ?g. }

• W2885382697 endingPage "872" @default.
• W2885382697 startingPage "864" @default.
• W2885382697 abstract "Objectives To examine combined immunoprofiles of epidermal growth factor receptor (EGFR), CD 44, and p16 in oropharyngeal squamous cell carcinoma ( OPSCC ) and to correlate them with radiotherapy treatment outcomes and clinicopathological parameters. Prognostic impact of the American Joint Committee on Cancer ( AJCC ) 8th edition staging system in comparison with 7th edition was analyzed. Methods The study included 77 OPSCC patients treated by definitive intensity‐modulated radiotherapy ( IMRT ). Clinical staging was assessed according to the AJCC , both 7th and 8th edition. Immunohistochemical ( IHC ) analysis of CD 44 and EGFR was performed on primary biopsy tumor tissues. To evaluate the HPV status, IHC detection of p16 was employed. Results The AJCC 8th edition staging system revealed correlations between overall survival ( OS ), progression‐free survival ( PFS ), locoregional control ( LRC ), and clinical stage. EGFR and CD 44 positivity (+) and p16 negativity (−) were associated with clinical stage IV of the disease. CD 44+ and EGFR + OPSCC displayed worse OS and LRC , and these cases also showed the worst 3‐year OS and LRC . Combined analysis of protein expressions identified an association between p16− and EGFR +, p16− and CD 44+, EGFR +, and CD 44+. Combined immunoprofiles CD 44+/p16−, EGFR +/p16−, and EGFR +/ CD 44+ were associated with worst OS and LRC . Conclusions Combined immunoprofiles of p16, EGFR , and CD 44 might provide valuable prognostic and predictive information for the individual OPSCC patients, especially in terms of response to IMRT and prediction of treatment outcomes. Application of the AJCC 8th edition staging for HPV + OPSCC proved to improve hazard discrimination and prognostication of OPSCC ." @default.
• W2885382697 created "2018-08-22" @default.
• W2885382697 creator A5002633821 @default.
• W2885382697 creator A5010070693 @default.
• W2885382697 creator A5011798138 @default.
• W2885382697 creator A5027976967 @default.
• W2885382697 creator A5033784811 @default.
• W2885382697 creator A5034158569 @default.
• W2885382697 creator A5039222717 @default.
• W2885382697 creator A5047969098 @default.
• W2885382697 creator A5050370767 @default.
• W2885382697 creator A5050763228 @default.
• W2885382697 creator A5063452175 @default.
• W2885382697 creator A5064065812 @default.
• W2885382697 creator A5090844895 @default.
• W2885382697 date "2018-08-25" @default.
• W2885382697 modified "2023-10-10" @default.
• W2885382697 title "Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to <scp>AJCC</scp> 8th edition" @default.
• W2885382697 cites W1968108709 @default.
• W2885382697 cites W1974069520 @default.
• W2885382697 cites W1974685860 @default.
• W2885382697 cites W1993295950 @default.
• W2885382697 cites W2021006076 @default.
• W2885382697 cites W2027511840 @default.
• W2885382697 cites W2032660848 @default.
• W2885382697 cites W2044288985 @default.
• W2885382697 cites W2050333466 @default.
• W2885382697 cites W2076050110 @default.
• W2885382697 cites W2103046543 @default.
• W2885382697 cites W2107283868 @default.
• W2885382697 cites W2110664940 @default.
• W2885382697 cites W2130779144 @default.
• W2885382697 cites W2131971625 @default.
• W2885382697 cites W2133671622 @default.
• W2885382697 cites W2141699607 @default.
• W2885382697 cites W2148472692 @default.
• W2885382697 cites W2208711857 @default.
• W2885382697 cites W2252597333 @default.
• W2885382697 cites W2403124237 @default.
• W2885382697 cites W2498105219 @default.
• W2885382697 cites W2502134830 @default.
• W2885382697 cites W2605514883 @default.
• W2885382697 cites W2622219590 @default.
• W2885382697 cites W2779288253 @default.
• W2885382697 cites W2917837889 @default.
• W2885382697 doi "https://doi.org/10.1111/jop.12772" @default.
• W2885382697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30079604" @default.
• W2885382697 hasPublicationYear "2018" @default.
• W2885382697 type Work @default.
• W2885382697 sameAs 2885382697 @default.
• W2885382697 citedByCount "4" @default.
• W2885382697 countsByYear W28853826972019 @default.
• W2885382697 countsByYear W28853826972020 @default.
• W2885382697 countsByYear W28853826972023 @default.
• W2885382697 crossrefType "journal-article" @default.
• W2885382697 hasAuthorship W2885382697A5002633821 @default.
• W2885382697 hasAuthorship W2885382697A5010070693 @default.
• W2885382697 hasAuthorship W2885382697A5011798138 @default.
• W2885382697 hasAuthorship W2885382697A5027976967 @default.
• W2885382697 hasAuthorship W2885382697A5033784811 @default.
• W2885382697 hasAuthorship W2885382697A5034158569 @default.
• W2885382697 hasAuthorship W2885382697A5039222717 @default.
• W2885382697 hasAuthorship W2885382697A5047969098 @default.
• W2885382697 hasAuthorship W2885382697A5050370767 @default.
• W2885382697 hasAuthorship W2885382697A5050763228 @default.
• W2885382697 hasAuthorship W2885382697A5063452175 @default.
• W2885382697 hasAuthorship W2885382697A5064065812 @default.
• W2885382697 hasAuthorship W2885382697A5090844895 @default.
• W2885382697 hasConcept C121608353 @default.
• W2885382697 hasConcept C126322002 @default.
• W2885382697 hasConcept C143998085 @default.
• W2885382697 hasConcept C146357865 @default.
• W2885382697 hasConcept C151730666 @default.
• W2885382697 hasConcept C204232928 @default.
• W2885382697 hasConcept C207103383 @default.
• W2885382697 hasConcept C2775934546 @default.
• W2885382697 hasConcept C2779438470 @default.
• W2885382697 hasConcept C2780091936 @default.
• W2885382697 hasConcept C2780325254 @default.
• W2885382697 hasConcept C44249647 @default.
• W2885382697 hasConcept C50382708 @default.
• W2885382697 hasConcept C509974204 @default.
• W2885382697 hasConcept C71924100 @default.
• W2885382697 hasConcept C86803240 @default.
• W2885382697 hasConceptScore W2885382697C121608353 @default.
• W2885382697 hasConceptScore W2885382697C126322002 @default.
• W2885382697 hasConceptScore W2885382697C143998085 @default.
• W2885382697 hasConceptScore W2885382697C146357865 @default.
• W2885382697 hasConceptScore W2885382697C151730666 @default.
• W2885382697 hasConceptScore W2885382697C204232928 @default.
• W2885382697 hasConceptScore W2885382697C207103383 @default.
• W2885382697 hasConceptScore W2885382697C2775934546 @default.
• W2885382697 hasConceptScore W2885382697C2779438470 @default.
• W2885382697 hasConceptScore W2885382697C2780091936 @default.
• W2885382697 hasConceptScore W2885382697C2780325254 @default.
• W2885382697 hasConceptScore W2885382697C44249647 @default.
• W2885382697 hasConceptScore W2885382697C50382708 @default.
• W2885382697 hasConceptScore W2885382697C509974204 @default.

• next