FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885382822> ?p ?o ?g. }

• W2885382822 endingPage "3024" @default.
• W2885382822 startingPage "3016" @default.
• W2885382822 abstract "Colistin has been used as the last therapeutic resort for treatment of MDR Gram-negative bacteria infections in humans. The two-component system CpxAR has been reported to contribute to the MDR of bacteria. There may be a more complex network mediated by CpxAR contributing to colistin susceptibility than previously understood.A series of AcrB or CpxR deletion mutants of a multidrug-susceptible standard strain of Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) was constructed in our previous study. MICs of colistin were determined by the 2-fold serial broth microdilution method. Time-kill and survival assays were carried out with various concentrations of colistin. Growth curves and starvation survival were measured by OD600 or cfu count in LB and M9-glucose (0.2%) minimum media. Quantitative RT-PCR was used to determine the mRNA expression levels of target genes.The results showed that the MIC of colistin for the CpxR-overexpressed strain JSΔacrBΔcpxR::kan/pcpxR was dramatically decreased (0.05 mg/L) by 16-fold compared with JS (0.8 mg/L) and JSΔacrBΔcpxR::kan (0.8 mg/L). Colistin time-kill and survival assays showed that JSΔacrBΔcpxR::kan/pcpxR was more susceptible to colistin (0.05 mg/L), but had a considerably higher survivability regarding prolonged starvation stress compared with JSΔacrBΔcpxR::kan. Furthermore, the expression levels of colistin resistance-related genes (phoP, phoQ, pmrB, pmrC, pmrH and pmrD) were found to be remarkably down-regulated and the negative regulatory protein mgrB was significantly up-regulated.This study demonstrated that CpxR may regulate the colistin susceptibility of Salmonella Typhimurium through the PmrAB and PhoPQ regulatory systems." @default.
• W2885382822 created "2018-08-22" @default.
• W2885382822 creator A5007478291 @default.
• W2885382822 creator A5027258102 @default.
• W2885382822 creator A5031460345 @default.
• W2885382822 creator A5039614440 @default.
• W2885382822 creator A5041057598 @default.
• W2885382822 creator A5083017878 @default.
• W2885382822 creator A5084065322 @default.
• W2885382822 date "2018-08-10" @default.
• W2885382822 modified "2023-10-10" @default.
• W2885382822 title "CpxR overexpression increases the susceptibility of acrB and cpxR double-deleted Salmonella enterica serovar Typhimurium to colistin" @default.
• W2885382822 cites W1547922007 @default.
• W2885382822 cites W1963955907 @default.
• W2885382822 cites W1983003534 @default.
• W2885382822 cites W2000470168 @default.
• W2885382822 cites W2000951555 @default.
• W2885382822 cites W2009914378 @default.
• W2885382822 cites W2019509230 @default.
• W2885382822 cites W2024673940 @default.
• W2885382822 cites W2029495773 @default.
• W2885382822 cites W2029956246 @default.
• W2885382822 cites W2046240114 @default.
• W2885382822 cites W2074166043 @default.
• W2885382822 cites W2079025858 @default.
• W2885382822 cites W2079260453 @default.
• W2885382822 cites W2097952974 @default.
• W2885382822 cites W2106171353 @default.
• W2885382822 cites W2107183457 @default.
• W2885382822 cites W2116201639 @default.
• W2885382822 cites W2116245384 @default.
• W2885382822 cites W2117508830 @default.
• W2885382822 cites W2127136344 @default.
• W2885382822 cites W2132296494 @default.
• W2885382822 cites W2138214676 @default.
• W2885382822 cites W2152258283 @default.
• W2885382822 cites W2157979510 @default.
• W2885382822 cites W2159612861 @default.
• W2885382822 cites W2166846071 @default.
• W2885382822 cites W2168894173 @default.
• W2885382822 cites W2169110988 @default.
• W2885382822 cites W2169605967 @default.
• W2885382822 cites W2179036997 @default.
• W2885382822 cites W2285690440 @default.
• W2885382822 cites W2294844308 @default.
• W2885382822 cites W2345103162 @default.
• W2885382822 cites W2473625848 @default.
• W2885382822 cites W4211056710 @default.
• W2885382822 doi "https://doi.org/10.1093/jac/dky320" @default.
• W2885382822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30107570" @default.
• W2885382822 hasPublicationYear "2018" @default.
• W2885382822 type Work @default.
• W2885382822 sameAs 2885382822 @default.
• W2885382822 citedByCount "13" @default.
• W2885382822 countsByYear W28853828222019 @default.
• W2885382822 countsByYear W28853828222020 @default.
• W2885382822 countsByYear W28853828222021 @default.
• W2885382822 countsByYear W28853828222022 @default.
• W2885382822 countsByYear W28853828222023 @default.
• W2885382822 crossrefType "journal-article" @default.
• W2885382822 hasAuthorship W2885382822A5007478291 @default.
• W2885382822 hasAuthorship W2885382822A5027258102 @default.
• W2885382822 hasAuthorship W2885382822A5031460345 @default.
• W2885382822 hasAuthorship W2885382822A5039614440 @default.
• W2885382822 hasAuthorship W2885382822A5041057598 @default.
• W2885382822 hasAuthorship W2885382822A5083017878 @default.
• W2885382822 hasAuthorship W2885382822A5084065322 @default.
• W2885382822 hasBestOaLocation W28853828221 @default.
• W2885382822 hasConcept C10389963 @default.
• W2885382822 hasConcept C104317684 @default.
• W2885382822 hasConcept C143065580 @default.
• W2885382822 hasConcept C176947019 @default.
• W2885382822 hasConcept C2778910516 @default.
• W2885382822 hasConcept C2779259085 @default.
• W2885382822 hasConcept C2779607309 @default.
• W2885382822 hasConcept C2780950330 @default.
• W2885382822 hasConcept C2781065037 @default.
• W2885382822 hasConcept C501593827 @default.
• W2885382822 hasConcept C523546767 @default.
• W2885382822 hasConcept C54355233 @default.
• W2885382822 hasConcept C547475151 @default.
• W2885382822 hasConcept C86803240 @default.
• W2885382822 hasConcept C89423630 @default.
• W2885382822 hasConceptScore W2885382822C10389963 @default.
• W2885382822 hasConceptScore W2885382822C104317684 @default.
• W2885382822 hasConceptScore W2885382822C143065580 @default.
• W2885382822 hasConceptScore W2885382822C176947019 @default.
• W2885382822 hasConceptScore W2885382822C2778910516 @default.
• W2885382822 hasConceptScore W2885382822C2779259085 @default.
• W2885382822 hasConceptScore W2885382822C2779607309 @default.
• W2885382822 hasConceptScore W2885382822C2780950330 @default.
• W2885382822 hasConceptScore W2885382822C2781065037 @default.
• W2885382822 hasConceptScore W2885382822C501593827 @default.
• W2885382822 hasConceptScore W2885382822C523546767 @default.
• W2885382822 hasConceptScore W2885382822C54355233 @default.
• W2885382822 hasConceptScore W2885382822C547475151 @default.
• W2885382822 hasConceptScore W2885382822C86803240 @default.
• W2885382822 hasConceptScore W2885382822C89423630 @default.

• next