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- W2885385969 abstract "Background Pacemakers and theophylline are currently being used to relieve symptoms in patients with sick sinus syndrome (SSS). However, the impact of either therapy on the natural course of the disease is unknown. We conducted a randomized controlled trial to prospectively assess the effects of pacemakers and theophylline in patients with SSS. Methods and Results One hundred seven patients with symptomatic SSS (age, 73±11 years) were randomized to no treatment (control group, n=35), oral theophylline (n=36), or dual-chamber rate-responsive pacemaker therapy (n=36). They were followed for up to 48 months (mean, 19±14 months). During follow-up, the occurrence of syncope was lower in the pacemaker group than in the control group (P=.02) and tended to be lower than in the theophylline group (P=.07). Heart failure occurred less often in patients assigned to pacemaker therapy and theophylline than in control patients (both, P=.05), whereas the incidence of sustained paroxysmal tachyarrhythmias, permanent atria..." @default.
- W2885385969 created "2018-08-22" @default.
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- W2885385969 date "1997-07-01" @default.
- W2885385969 modified "2023-09-26" @default.
- W2885385969 title "Effects of Permanent Pacemaker and Oral Theophylline in Sick Sinus Syndrome" @default.
- W2885385969 hasPublicationYear "1997" @default.
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