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• W2885387051 abstract "The collagenase secreted by Grimontia hollisae strain 1706B is a 74 kDa protein that consists of two parts: the catalytic module and a C‐terminal segment that includes the bacterial pre‐peptidase C‐terminal domain. Here, we produced a recombinant C‐terminal segment protein and examined its ability to bind collagen and other characteristics as compared with collagen‐binding domains ( CBD s) derived from Hathewaya histolytica ( Clostridium histolyticum ) collagenases; these CBD s are the only ones thus far identified in bacterial collagenases. We found that the C‐terminal segment binds to collagen only when the collagen is in its triple‐helical conformation. Moreover, the C‐terminal segment and the CBD s from H. histolytica have comparable characteristics, including binding affinity to type I collagen, substrate spectrum, and binding conditions with respect to salt concentration and pH . However, the C‐terminal segment has a completely different primary structure from those of the CBD s from H. histolytica . As regards secondary structure, in silico prediction indicates that the C‐terminal segment may be homologous to those in CBD s from H. histolytica . Furthermore, we performed collagenase assays using fluorescein isothiocyanate‐labeled type I collagen to show that the C‐terminal segment positively contributes to the collagenolytic activity of the 74 kDa collagenase from G. hollisae ." @default.
• W2885387051 created "2018-08-22" @default.
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• W2885387051 date "2018-09-06" @default.
• W2885387051 modified "2023-10-06" @default.
• W2885387051 title "The C‐terminal segment of collagenase in <i>Grimontia hollisae</i> binds collagen to enhance collagenolysis" @default.
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• W2885387051 doi "https://doi.org/10.1002/2211-5463.12510" @default.
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