Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885387960> ?p ?o ?g. }
- W2885387960 endingPage "454" @default.
- W2885387960 startingPage "445" @default.
- W2885387960 abstract "Porous scaffolds fabricated with nano-hydroxyapatite (nHA) and chitosan (CTS), are widely used in bone tissue engineering (BTE). However, cell adhesion is relatively poor in nHA/CTS scaffolds, which also do not provide an ideal three-dimensional environment for seed cells. These deficiencies limit the applicability of these BTE scaffolds to repair bone defects. To address these challenges, we designed a composite scaffold that combines nHA/CTS with self-assembling peptide (SAP), a material which is similar to the extracellular matrix. We found that SAP/nHA/CTS scaffolds both increased the adhesion of bone mesenchymal stem cells (BMSCs) and enhanced the mechanical properties of the scaffold. This composite scaffold was then used to repair a femoral condylar bone defect in a mouse model. Healing and mineralization was demonstrated after 12 weeks using H&E staining, microcomputerized tomography, and bone mineral density tests. To our knowledge, this is the first report that SAP/nHA/CTS scaffolds can increase cell adhesion and promote the reconstruction of femoral condylar bone defects. Moreover, this study indicates that BTE using a SAP/nHA/CTS scaffold may be a novel prospective strategy for healing extensive bone defects." @default.
- W2885387960 created "2018-08-22" @default.
- W2885387960 creator A5007264715 @default.
- W2885387960 creator A5028002353 @default.
- W2885387960 creator A5034711601 @default.
- W2885387960 creator A5047231994 @default.
- W2885387960 creator A5048463835 @default.
- W2885387960 creator A5068862707 @default.
- W2885387960 creator A5081151068 @default.
- W2885387960 creator A5084363318 @default.
- W2885387960 creator A5091852511 @default.
- W2885387960 date "2018-12-01" @default.
- W2885387960 modified "2023-10-16" @default.
- W2885387960 title "Self-assembling peptide and nHA/CTS composite scaffolds promote bone regeneration through increasing seed cell adhesion" @default.
- W2885387960 cites W1898695687 @default.
- W2885387960 cites W1969864388 @default.
- W2885387960 cites W1970906375 @default.
- W2885387960 cites W1983392170 @default.
- W2885387960 cites W1985692604 @default.
- W2885387960 cites W1985898640 @default.
- W2885387960 cites W1987190449 @default.
- W2885387960 cites W1991471647 @default.
- W2885387960 cites W1994889228 @default.
- W2885387960 cites W2005062100 @default.
- W2885387960 cites W2017479018 @default.
- W2885387960 cites W2021011246 @default.
- W2885387960 cites W2042589577 @default.
- W2885387960 cites W2046425583 @default.
- W2885387960 cites W2049360074 @default.
- W2885387960 cites W2058013401 @default.
- W2885387960 cites W2066759563 @default.
- W2885387960 cites W2090836893 @default.
- W2885387960 cites W2099995006 @default.
- W2885387960 cites W2103904125 @default.
- W2885387960 cites W2133482750 @default.
- W2885387960 cites W2138939593 @default.
- W2885387960 cites W2148009863 @default.
- W2885387960 cites W2153062376 @default.
- W2885387960 cites W2160471868 @default.
- W2885387960 cites W2166737756 @default.
- W2885387960 cites W2193332798 @default.
- W2885387960 cites W2468261371 @default.
- W2885387960 cites W2522851280 @default.
- W2885387960 cites W2566426861 @default.
- W2885387960 cites W2573650013 @default.
- W2885387960 cites W2584892916 @default.
- W2885387960 cites W2602024596 @default.
- W2885387960 cites W2604992226 @default.
- W2885387960 cites W2617870230 @default.
- W2885387960 cites W2668361924 @default.
- W2885387960 cites W2736400110 @default.
- W2885387960 cites W2750958779 @default.
- W2885387960 cites W2754544242 @default.
- W2885387960 cites W2756193470 @default.
- W2885387960 cites W2756378009 @default.
- W2885387960 cites W2757209889 @default.
- W2885387960 cites W2793381631 @default.
- W2885387960 doi "https://doi.org/10.1016/j.msec.2018.07.079" @default.
- W2885387960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30274077" @default.
- W2885387960 hasPublicationYear "2018" @default.
- W2885387960 type Work @default.
- W2885387960 sameAs 2885387960 @default.
- W2885387960 citedByCount "17" @default.
- W2885387960 countsByYear W28853879602019 @default.
- W2885387960 countsByYear W28853879602021 @default.
- W2885387960 countsByYear W28853879602022 @default.
- W2885387960 countsByYear W28853879602023 @default.
- W2885387960 crossrefType "journal-article" @default.
- W2885387960 hasAuthorship W2885387960A5007264715 @default.
- W2885387960 hasAuthorship W2885387960A5028002353 @default.
- W2885387960 hasAuthorship W2885387960A5034711601 @default.
- W2885387960 hasAuthorship W2885387960A5047231994 @default.
- W2885387960 hasAuthorship W2885387960A5048463835 @default.
- W2885387960 hasAuthorship W2885387960A5068862707 @default.
- W2885387960 hasAuthorship W2885387960A5081151068 @default.
- W2885387960 hasAuthorship W2885387960A5084363318 @default.
- W2885387960 hasAuthorship W2885387960A5091852511 @default.
- W2885387960 hasConcept C105702510 @default.
- W2885387960 hasConcept C136229726 @default.
- W2885387960 hasConcept C159985019 @default.
- W2885387960 hasConcept C185592680 @default.
- W2885387960 hasConcept C189165786 @default.
- W2885387960 hasConcept C192562407 @default.
- W2885387960 hasConcept C55493867 @default.
- W2885387960 hasConcept C71924100 @default.
- W2885387960 hasConcept C8337478 @default.
- W2885387960 hasConcept C84416704 @default.
- W2885387960 hasConcept C85789140 @default.
- W2885387960 hasConcept C89429830 @default.
- W2885387960 hasConceptScore W2885387960C105702510 @default.
- W2885387960 hasConceptScore W2885387960C136229726 @default.
- W2885387960 hasConceptScore W2885387960C159985019 @default.
- W2885387960 hasConceptScore W2885387960C185592680 @default.
- W2885387960 hasConceptScore W2885387960C189165786 @default.
- W2885387960 hasConceptScore W2885387960C192562407 @default.
- W2885387960 hasConceptScore W2885387960C55493867 @default.
- W2885387960 hasConceptScore W2885387960C71924100 @default.
- W2885387960 hasConceptScore W2885387960C8337478 @default.