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- W2885397907 abstract "Background and Purpose—The effects of acute smoking on cerebral circulation are controversial. This study was designed (1) to clarify any differences between the effects of cigarette smoking and nicotine infusion and between the effects of single- and multiple-cigarette smoking on cerebral vessels and (2) to probe the mechanism(s) underlying the vascular responses. Methods—In pentobarbital-anesthetized, mechanically ventilated Sprague-Dawley rats, pial vessel diameters were measured with the use of a cranial window preparation. We studied the effects of (1) 60 puffs per minute of mainstream cigarette smoke from cigarettes having 2 nicotine levels (0.1 and 1 mg per cigarette), (2) administration of nicotine (0.05 mg per body IV), and (3) repeated smoking (four 1 mg nicotine–containing cigarettes at 30-minute intervals) (n=6 each). Results—Inhalation of smoke from a 0.1 or 1 mg nicotine–containing cigarette for 1 minute caused pial arterioles to constrict at 30 seconds (7.2% and 7.3%, respectively) and then..." @default.
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- W2885397907 date "1998-08-01" @default.
- W2885397907 modified "2023-09-22" @default.
- W2885397907 title "Mechanisms Underlying Cerebrovascular Effects of Cigarette Smoking in Rats In Vivo" @default.
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