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- W2885398462 abstract "Abstract Pancreatic cancer is the third leading cause of cancer death in the United States, with projections that it will become the second leading cause by the year 2030. It carries a dismal prognosis with a 5-year overall survival rate of less than 9% and is associated with numerous comorbidities, the most notable being cachexia. Defined as the loss of muscle mass not reversible by conventional nutritional support, cachexia is seen in over 85% of pancreatic cancer patients and contributes significantly to mortality, where nearly 30% of pancreatic cancer deaths are due to cachexia rather than tumor burden. Therefore, there is an urgent need to identify the mechanisms behind the development of muscle wasting in pancreatic cancer patients and design novel therapeutics targeting cachexia. This review highlights the current understanding surrounding the mechanisms underpinning the development of cachexia in pancreatic cancer, as well as the current mouse models of pancreatic cancer–induced muscle wasting described in the literature." @default.
- W2885398462 created "2018-08-22" @default.
- W2885398462 creator A5003348560 @default.
- W2885398462 creator A5018133674 @default.
- W2885398462 creator A5066671433 @default.
- W2885398462 date "2018-09-01" @default.
- W2885398462 modified "2023-10-10" @default.
- W2885398462 title "Pancreatic Cancer–Induced Cachexia and Relevant Mouse Models" @default.
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- W2885398462 doi "https://doi.org/10.1097/mpa.0000000000001124" @default.
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- W2885398462 hasPublicationYear "2018" @default.
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