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- W2885405501 endingPage "e0201317" @default.
- W2885405501 startingPage "e0201317" @default.
- W2885405501 abstract "Growth and patterning are coordinated during development to define organ size and shape. The growth, proliferation and differentiation of Drosophila wings are regulated by several conserved signaling pathways. Here, we show that the Salvador-Warts-Hippo (SWH) and Notch pathways converge on an enhancer in the expanded (ex) gene, which also responds to levels of the bHLH transcription factor Daughterless (Da). Separate cis-regulatory elements respond to Salvador-Warts-Hippo (SWH) and Notch pathways, to bHLH proteins, and to unidentified factors that repress ex transcription in the wing pouch and in the proneural region at the anterior wing margin. Senseless, a zinc-finger transcription factor acting in proneural regions, had a negative impact on ex transcription in the proneural region, but the transcriptional repressor Hairy had no effect. Our study suggests that a complex pattern of ex transcription results from integration of a uniform SWH signal with multiple other inputs, rather than from a pattern of SWH signaling." @default.
- W2885405501 created "2018-08-22" @default.
- W2885405501 creator A5028529010 @default.
- W2885405501 creator A5089282405 @default.
- W2885405501 date "2018-07-31" @default.
- W2885405501 modified "2023-10-17" @default.
- W2885405501 title "Spatial regulation of expanded transcription in the Drosophila wing imaginal disc" @default.
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- W2885405501 doi "https://doi.org/10.1371/journal.pone.0201317" @default.
- W2885405501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6067730" @default.
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- W2885405501 hasPublicationYear "2018" @default.
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