Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885405740> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2885405740 endingPage "8661" @default.
- W2885405740 startingPage "8656" @default.
- W2885405740 abstract "Abstract The work describes the synthesis and characterization of a small series of pyrroloquinoline carboxamide derivatives considered on the STX‐0119 model, a known inhibitor of STAT3 (Signal transducers and activators of transcription 3) by interacting with SH2 domain. The scope was to learn SARs and possibly obtain active new compounds for cancer therapy. To this aim, the quinoline scaffold of the lead compound STX‐0119 was modified into the pyrroloquinoline tricycle to obtain two subsets of carboxamide derivatives showing different angular geometry 3 H ‐pyrrolo[3, 2‐ f ] and 7 H ‐pyrrolo[2, 3‐ h ]quinolines. Successful synthesis of thirty compounds was carried out, adopting methods using both convergent and linear pathways. Amidic coupling chemistry was applied to pyrroloquinoline carboxylic acids to generate the desired carboxamides of aromatic and aliphatic primary and secondary amines. Full physico‐chemical characterization including predicted LogP and LogD of all compounds was accomplished. The biological screening of antiproliferative activity against three human tumor cell lines by MTT test revealed low or no activity." @default.
- W2885405740 created "2018-08-22" @default.
- W2885405740 creator A5013217180 @default.
- W2885405740 creator A5033538842 @default.
- W2885405740 creator A5081152092 @default.
- W2885405740 date "2018-08-07" @default.
- W2885405740 modified "2023-10-16" @default.
- W2885405740 title "Amidic Coupling in the Synthesis of Pyrroloquinoline 4‐ and 9‐Carboxamides as Potential STAT3 Inhibitors" @default.
- W2885405740 cites W1985788857 @default.
- W2885405740 cites W2013249816 @default.
- W2885405740 cites W2041513075 @default.
- W2885405740 cites W2041630026 @default.
- W2885405740 cites W2060489303 @default.
- W2885405740 cites W2077999767 @default.
- W2885405740 cites W2096551654 @default.
- W2885405740 cites W2110034822 @default.
- W2885405740 cites W2119359836 @default.
- W2885405740 cites W2132325880 @default.
- W2885405740 cites W2135732933 @default.
- W2885405740 cites W2137648328 @default.
- W2885405740 cites W2159042224 @default.
- W2885405740 cites W2314621992 @default.
- W2885405740 cites W2536080685 @default.
- W2885405740 cites W2590098940 @default.
- W2885405740 cites W2734462992 @default.
- W2885405740 cites W2770472795 @default.
- W2885405740 doi "https://doi.org/10.1002/slct.201801670" @default.
- W2885405740 hasPublicationYear "2018" @default.
- W2885405740 type Work @default.
- W2885405740 sameAs 2885405740 @default.
- W2885405740 citedByCount "2" @default.
- W2885405740 countsByYear W28854057402019 @default.
- W2885405740 countsByYear W28854057402020 @default.
- W2885405740 crossrefType "journal-article" @default.
- W2885405740 hasAuthorship W2885405740A5013217180 @default.
- W2885405740 hasAuthorship W2885405740A5033538842 @default.
- W2885405740 hasAuthorship W2885405740A5081152092 @default.
- W2885405740 hasConcept C114373084 @default.
- W2885405740 hasConcept C116073593 @default.
- W2885405740 hasConcept C178790620 @default.
- W2885405740 hasConcept C185592680 @default.
- W2885405740 hasConcept C202751555 @default.
- W2885405740 hasConcept C21951064 @default.
- W2885405740 hasConcept C2776309666 @default.
- W2885405740 hasConcept C2778327999 @default.
- W2885405740 hasConcept C2780104969 @default.
- W2885405740 hasConcept C2780783641 @default.
- W2885405740 hasConcept C523546767 @default.
- W2885405740 hasConcept C54355233 @default.
- W2885405740 hasConcept C55493867 @default.
- W2885405740 hasConcept C71240020 @default.
- W2885405740 hasConcept C86803240 @default.
- W2885405740 hasConceptScore W2885405740C114373084 @default.
- W2885405740 hasConceptScore W2885405740C116073593 @default.
- W2885405740 hasConceptScore W2885405740C178790620 @default.
- W2885405740 hasConceptScore W2885405740C185592680 @default.
- W2885405740 hasConceptScore W2885405740C202751555 @default.
- W2885405740 hasConceptScore W2885405740C21951064 @default.
- W2885405740 hasConceptScore W2885405740C2776309666 @default.
- W2885405740 hasConceptScore W2885405740C2778327999 @default.
- W2885405740 hasConceptScore W2885405740C2780104969 @default.
- W2885405740 hasConceptScore W2885405740C2780783641 @default.
- W2885405740 hasConceptScore W2885405740C523546767 @default.
- W2885405740 hasConceptScore W2885405740C54355233 @default.
- W2885405740 hasConceptScore W2885405740C55493867 @default.
- W2885405740 hasConceptScore W2885405740C71240020 @default.
- W2885405740 hasConceptScore W2885405740C86803240 @default.
- W2885405740 hasFunder F4320321966 @default.
- W2885405740 hasIssue "30" @default.
- W2885405740 hasLocation W28854057401 @default.
- W2885405740 hasOpenAccess W2885405740 @default.
- W2885405740 hasPrimaryLocation W28854057401 @default.
- W2885405740 hasRelatedWork W1981072141 @default.
- W2885405740 hasRelatedWork W1990675881 @default.
- W2885405740 hasRelatedWork W2024071413 @default.
- W2885405740 hasRelatedWork W2026927343 @default.
- W2885405740 hasRelatedWork W2033696307 @default.
- W2885405740 hasRelatedWork W2049124617 @default.
- W2885405740 hasRelatedWork W2180926579 @default.
- W2885405740 hasRelatedWork W2282590766 @default.
- W2885405740 hasRelatedWork W2952407896 @default.
- W2885405740 hasRelatedWork W1485835665 @default.
- W2885405740 hasVolume "3" @default.
- W2885405740 isParatext "false" @default.
- W2885405740 isRetracted "false" @default.
- W2885405740 magId "2885405740" @default.
- W2885405740 workType "article" @default.