Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885408146> ?p ?o ?g. }
- W2885408146 abstract "Background Breast cancer (BC) ranks among the most common cancers in Sudan and worldwide with hefty toll on female health and human resources. Recent studies have uncovered a common BC signature characterized by low frequency of oncogenic mutations and high frequency of epigenetic silencing of major BC tumor suppressor genes. Therefore, we conducted a pilot genome-wide methylome study to characterize aberrant DNA methylation in breast cancer. Results Differential methylation analysis between primary tumor samples and normal samples from healthy adjacent tissues yielded 20188 differentially methylated positions (DMPs), which is further divided into 13633 hypermethylated sites corresponding to 5339 genes and 6555 hypomethylated sites corresponding to 2811 genes. Moreover, bioinformatics analysis revealed epigenetic dysregulation of major developmental pathways including hippo signaling pathway. We also uncovered many clues to a possible role for EBV infection in BC Conclusion Our results clearly show the utility of epigenetic assays in interrogating breast cancer tumorigenesis, and pinpointing specific developmental and viral pathways dysregulation that might serve as potential biomarkers or targets for therapeutic interventions." @default.
- W2885408146 created "2018-08-22" @default.
- W2885408146 creator A5000877781 @default.
- W2885408146 creator A5003851555 @default.
- W2885408146 creator A5024320296 @default.
- W2885408146 creator A5032327403 @default.
- W2885408146 creator A5033800877 @default.
- W2885408146 creator A5036907012 @default.
- W2885408146 creator A5037881397 @default.
- W2885408146 creator A5039050716 @default.
- W2885408146 creator A5045148608 @default.
- W2885408146 creator A5068332189 @default.
- W2885408146 creator A5015648407 @default.
- W2885408146 date "2018-08-13" @default.
- W2885408146 modified "2023-09-23" @default.
- W2885408146 title "EBV Associated Breast Cancer Whole Methylome Analysis Reveals Viral and Developmental Enriched Pathways" @default.
- W2885408146 cites W102511770 @default.
- W2885408146 cites W1479907808 @default.
- W2885408146 cites W1545141073 @default.
- W2885408146 cites W1583240815 @default.
- W2885408146 cites W1964538769 @default.
- W2885408146 cites W1970646254 @default.
- W2885408146 cites W1971770814 @default.
- W2885408146 cites W1971943164 @default.
- W2885408146 cites W1973051534 @default.
- W2885408146 cites W1973767578 @default.
- W2885408146 cites W1976472776 @default.
- W2885408146 cites W1979594866 @default.
- W2885408146 cites W1986352281 @default.
- W2885408146 cites W1996898892 @default.
- W2885408146 cites W2004459316 @default.
- W2885408146 cites W2011336811 @default.
- W2885408146 cites W2019769511 @default.
- W2885408146 cites W2027671549 @default.
- W2885408146 cites W2028093625 @default.
- W2885408146 cites W2031330018 @default.
- W2885408146 cites W2034594496 @default.
- W2885408146 cites W2035122273 @default.
- W2885408146 cites W2037966798 @default.
- W2885408146 cites W2048839883 @default.
- W2885408146 cites W2058539819 @default.
- W2885408146 cites W2069813771 @default.
- W2885408146 cites W2074448914 @default.
- W2885408146 cites W2075099204 @default.
- W2885408146 cites W2076154138 @default.
- W2885408146 cites W2076790491 @default.
- W2885408146 cites W2079015343 @default.
- W2885408146 cites W2081098333 @default.
- W2885408146 cites W2083087817 @default.
- W2885408146 cites W2083853617 @default.
- W2885408146 cites W2089050884 @default.
- W2885408146 cites W2089592934 @default.
- W2885408146 cites W2090428544 @default.
- W2885408146 cites W2091001933 @default.
- W2885408146 cites W2092003419 @default.
- W2885408146 cites W2110488192 @default.
- W2885408146 cites W2114912562 @default.
- W2885408146 cites W2115640312 @default.
- W2885408146 cites W2116356111 @default.
- W2885408146 cites W2117961743 @default.
- W2885408146 cites W2122271532 @default.
- W2885408146 cites W2123063573 @default.
- W2885408146 cites W2125342106 @default.
- W2885408146 cites W2130330090 @default.
- W2885408146 cites W2131869455 @default.
- W2885408146 cites W2136482257 @default.
- W2885408146 cites W2137048052 @default.
- W2885408146 cites W2141105144 @default.
- W2885408146 cites W2142798802 @default.
- W2885408146 cites W2146390965 @default.
- W2885408146 cites W2153250619 @default.
- W2885408146 cites W2154162926 @default.
- W2885408146 cites W2154968746 @default.
- W2885408146 cites W2158667059 @default.
- W2885408146 cites W2159243840 @default.
- W2885408146 cites W2159675211 @default.
- W2885408146 cites W2161645441 @default.
- W2885408146 cites W2165880784 @default.
- W2885408146 cites W2170974258 @default.
- W2885408146 cites W2256451579 @default.
- W2885408146 cites W2334750333 @default.
- W2885408146 cites W4234935126 @default.
- W2885408146 doi "https://doi.org/10.3389/fonc.2018.00316" @default.
- W2885408146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6099083" @default.
- W2885408146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30151354" @default.
- W2885408146 hasPublicationYear "2018" @default.
- W2885408146 type Work @default.
- W2885408146 sameAs 2885408146 @default.
- W2885408146 citedByCount "13" @default.
- W2885408146 countsByYear W28854081462019 @default.
- W2885408146 countsByYear W28854081462020 @default.
- W2885408146 countsByYear W28854081462021 @default.
- W2885408146 countsByYear W28854081462022 @default.
- W2885408146 countsByYear W28854081462023 @default.
- W2885408146 crossrefType "journal-article" @default.
- W2885408146 hasAuthorship W2885408146A5000877781 @default.
- W2885408146 hasAuthorship W2885408146A5003851555 @default.
- W2885408146 hasAuthorship W2885408146A5015648407 @default.
- W2885408146 hasAuthorship W2885408146A5024320296 @default.
- W2885408146 hasAuthorship W2885408146A5032327403 @default.