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• W2885428049 abstract "Cone-beam X-ray luminescence computed tomography (CB-XLCT) is an attractive hybrid imaging modality, and it has the potential of monitoring the metabolic processes of nanophosphors-based drugs in vivo. However, the XLCT imaging suffers from a severe ill-posed problem. In this work, a sparse nonconvex Lp (0 < p < 1) regularization was utilized for the efficient reconstruction for early detection of small tumour in CB-XLCT imaging. Specifically, we transformed the non-convex optimization problem into an iteratively reweighted scheme based on the L1 regularization. Further, an iteratively reweighted split augmented lagrangian shrinkage algorithm (IRW_SALSA-Lp) was proposed to efficiently solve the non-convex Lp (0 < p < 1) model. We studied eight different non-convex p-values (1/16, 1/8, 1/4, 3/8, 1/2, 5/8, 3/4, 7/8) in both 3D digital mouse experiments and in vivo experiments. The results demonstrate that the proposed non-convex methods outperform L2 and L1 regularization in accurately recovering sparse targets in CB-XLCT. And among all the non-convex p-values, our Lp(1/4 < p < 1/2) methods give the best performance." @default.
• W2885428049 created "2018-08-22" @default.
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• W2885428049 date "2018-07-30" @default.
• W2885428049 modified "2023-09-26" @default.
• W2885428049 title "Sparse non-convex <i>L_p</i> regularization for cone-beam X-ray luminescence computed tomography" @default.
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• W2885428049 doi "https://doi.org/10.1080/09500340.2018.1502825" @default.
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