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- W2885441805 abstract "Abundance of connexin 43 (Cx43), a transmembrane protein that forms hemichannels (HCs) and gap junctions (GJs), is dynamically regulated in human gingival fibroblasts (GFBLs) during wound healing. This may be important for fast and scarless gingival wound healing as Cx43 is involved in key cell functions important during this process. Our aim was to uncover the factors that regulate Cx43 expression and abundance in GFBLs. We hypothesized that cytokines and growth factors released during wound healing coordinately regulate Cx43 abundance in GFBLs.TGF-β1, -β2, -β3, PGE2 and IL-1β significantly upregulated, while TNF-α and IFN-γ downregulated Cx43 in cultured GFBLs. TGF-β1, -β2, -β3, IL-1β and IFN-γ modulated Cx43 abundance at both mRNA and protein levels, while TNF-α and PGE2 regulated only Cx43 protein abundance, suggesting involvement of distinct transcriptional/post-transcriptional and translational/post-translational mechanisms, respectively. TGF-β1-induced upregulation of Cx43 was mediated by TGFβRI (ALK5) and SMAD2/3 signaling, and this was potently suppressed by PGE2, IL-1β, TNF-α and IFN-γ that inhibited SMAD2/3 phosphorylation.Regulation of Cx43 abundance in GFBLs involves transcriptional/post-transcriptional and translational/post-translational mechanisms that are distinctly modulated by an interplay between TGF-β isoforms and PGE2, IL-1β, TNF-α and IFN-γ." @default.
- W2885441805 created "2018-08-22" @default.
- W2885441805 creator A5032836116 @default.
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- W2885441805 creator A5048200369 @default.
- W2885441805 creator A5057419396 @default.
- W2885441805 creator A5066095948 @default.
- W2885441805 date "2018-10-01" @default.
- W2885441805 modified "2023-10-17" @default.
- W2885441805 title "Regulation of connexin 43 expression in human gingival fibroblasts" @default.
- W2885441805 cites W159247225 @default.
- W2885441805 cites W1593059529 @default.
- W2885441805 cites W1810441238 @default.
- W2885441805 cites W1929490865 @default.
- W2885441805 cites W1931315964 @default.
- W2885441805 cites W1949832432 @default.
- W2885441805 cites W1951419558 @default.
- W2885441805 cites W1969268991 @default.
- W2885441805 cites W1974144864 @default.
- W2885441805 cites W1981454925 @default.
- W2885441805 cites W1987436128 @default.
- W2885441805 cites W1989070304 @default.
- W2885441805 cites W1991230121 @default.
- W2885441805 cites W1991717581 @default.
- W2885441805 cites W1995438382 @default.
- W2885441805 cites W1998131759 @default.
- W2885441805 cites W1998721248 @default.
- W2885441805 cites W2005441602 @default.
- W2885441805 cites W2006027198 @default.
- W2885441805 cites W2006973776 @default.
- W2885441805 cites W2007548581 @default.
- W2885441805 cites W2010957325 @default.
- W2885441805 cites W2011284586 @default.
- W2885441805 cites W2011346692 @default.
- W2885441805 cites W2012003576 @default.
- W2885441805 cites W2015379482 @default.
- W2885441805 cites W2018202875 @default.
- W2885441805 cites W2035855639 @default.
- W2885441805 cites W2036657358 @default.
- W2885441805 cites W2038572073 @default.
- W2885441805 cites W2038699015 @default.
- W2885441805 cites W2051367002 @default.
- W2885441805 cites W2052972580 @default.
- W2885441805 cites W2053607267 @default.
- W2885441805 cites W2054343568 @default.
- W2885441805 cites W2064247589 @default.
- W2885441805 cites W2071673923 @default.
- W2885441805 cites W2071687168 @default.
- W2885441805 cites W2075469562 @default.
- W2885441805 cites W2079965945 @default.
- W2885441805 cites W2102019261 @default.
- W2885441805 cites W2106024776 @default.
- W2885441805 cites W2107637651 @default.
- W2885441805 cites W2113290395 @default.
- W2885441805 cites W2127130496 @default.
- W2885441805 cites W2132384646 @default.
- W2885441805 cites W2135566053 @default.
- W2885441805 cites W2138492071 @default.
- W2885441805 cites W2139807709 @default.
- W2885441805 cites W2144396367 @default.
- W2885441805 cites W2147011583 @default.
- W2885441805 cites W2149199950 @default.
- W2885441805 cites W2150556036 @default.
- W2885441805 cites W2152625046 @default.
- W2885441805 cites W2155540606 @default.
- W2885441805 cites W2158626287 @default.
- W2885441805 cites W2162338634 @default.
- W2885441805 cites W2162562455 @default.
- W2885441805 cites W2162569984 @default.
- W2885441805 cites W2167254595 @default.
- W2885441805 cites W2167589710 @default.
- W2885441805 cites W2168633577 @default.
- W2885441805 cites W2170082518 @default.
- W2885441805 cites W2171136408 @default.
- W2885441805 cites W2184184250 @default.
- W2885441805 cites W2279126440 @default.
- W2885441805 cites W2304775326 @default.
- W2885441805 cites W2411682568 @default.
- W2885441805 cites W2473514416 @default.
- W2885441805 cites W2560099801 @default.
- W2885441805 cites W2594270071 @default.
- W2885441805 cites W2611704384 @default.
- W2885441805 cites W2615042436 @default.
- W2885441805 cites W2620422973 @default.
- W2885441805 cites W2734511487 @default.
- W2885441805 cites W2760125379 @default.
- W2885441805 cites W2764185233 @default.
- W2885441805 cites W2766448145 @default.
- W2885441805 cites W2792213248 @default.
- W2885441805 cites W2794815709 @default.
- W2885441805 cites W2808673418 @default.
- W2885441805 doi "https://doi.org/10.1016/j.yexcr.2018.08.017" @default.
- W2885441805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30118696" @default.
- W2885441805 hasPublicationYear "2018" @default.
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