FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885442870> ?p ?o ?g. }

• W2885442870 abstract "Abstract The physiological function of the pancreas is controlled by the circadian clock. The aim of this study was to determine whether aging-induced changes in glucose homeostasis affect properties of the circadian clock in the pancreas and/or its sensitivity to disturbances in environmental lighting conditions. mPer2 Luc mice aged 24–26 months developed hyperinsulinemic hypoglycaemia, which was likely due to the Pclo -mediated insulin hyper-secretion and Slc2a2 -mediated glucose transport impairment in the pancreas, and due to the alterations in Pp1r3c -related glycogen storage and Sgk1 -related glucose transport in the liver. In the pancreatic tissue, aging affected clock gene expression only marginally, it upregulated Bmal1 and downregulated Clock expression. Whereas aging significantly impaired the circadian clock in lung explants, which were used as a control tissue, the properties of the pancreatic clock in vitro were not affected. The data suggest a non-circadian role of Bmal1 in changes of pancreatic function that occur during aging. Additionally, the pancreatic clock was more sensitive to exposure of animals to constant light conditions. These findings provide an explanation for the previously demonstrated relationship between disturbances in the circadian system and disordered glucose homeostasis, including diabetes mellitus type 2, in subjects exposed to long-term shift work." @default.
• W2885442870 created "2018-08-22" @default.
• W2885442870 creator A5001656619 @default.
• W2885442870 creator A5056397454 @default.
• W2885442870 creator A5072073786 @default.
• W2885442870 creator A5079950699 @default.
• W2885442870 date "2018-08-03" @default.
• W2885442870 modified "2023-10-14" @default.
• W2885442870 title "Alteration in glucose homeostasis and persistence of the pancreatic clock in aged mPer2Luc mice" @default.
• W2885442870 cites W1918892711 @default.
• W2885442870 cites W1921294170 @default.
• W2885442870 cites W1930786993 @default.
• W2885442870 cites W1971564932 @default.
• W2885442870 cites W1980685856 @default.
• W2885442870 cites W1989011389 @default.
• W2885442870 cites W1990569925 @default.
• W2885442870 cites W1993600658 @default.
• W2885442870 cites W2001669109 @default.
• W2885442870 cites W2013071776 @default.
• W2885442870 cites W2014313900 @default.
• W2885442870 cites W2027058093 @default.
• W2885442870 cites W2030386489 @default.
• W2885442870 cites W2034722299 @default.
• W2885442870 cites W2037808521 @default.
• W2885442870 cites W2041028158 @default.
• W2885442870 cites W2047923962 @default.
• W2885442870 cites W2056475677 @default.
• W2885442870 cites W2059438747 @default.
• W2885442870 cites W2076585242 @default.
• W2885442870 cites W2077789837 @default.
• W2885442870 cites W2081583189 @default.
• W2885442870 cites W2087419522 @default.
• W2885442870 cites W2090995115 @default.
• W2885442870 cites W2095455974 @default.
• W2885442870 cites W2095949680 @default.
• W2885442870 cites W2098934646 @default.
• W2885442870 cites W2108130957 @default.
• W2885442870 cites W2108235045 @default.
• W2885442870 cites W2131227905 @default.
• W2885442870 cites W2138521217 @default.
• W2885442870 cites W2140464228 @default.
• W2885442870 cites W2140968650 @default.
• W2885442870 cites W2142976933 @default.
• W2885442870 cites W2143210222 @default.
• W2885442870 cites W2146586614 @default.
• W2885442870 cites W2150042449 @default.
• W2885442870 cites W2158217833 @default.
• W2885442870 cites W2162650381 @default.
• W2885442870 cites W2195673264 @default.
• W2885442870 cites W2265211954 @default.
• W2885442870 cites W2410843339 @default.
• W2885442870 cites W2463250259 @default.
• W2885442870 cites W2476866952 @default.
• W2885442870 cites W2523564462 @default.
• W2885442870 cites W2543106070 @default.
• W2885442870 cites W2568631290 @default.
• W2885442870 cites W2743588819 @default.
• W2885442870 cites W2744641317 @default.
• W2885442870 cites W2766224553 @default.
• W2885442870 cites W2784394917 @default.
• W2885442870 doi "https://doi.org/10.1038/s41598-018-30225-y" @default.
• W2885442870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6076295" @default.
• W2885442870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30076390" @default.
• W2885442870 hasPublicationYear "2018" @default.
• W2885442870 type Work @default.
• W2885442870 sameAs 2885442870 @default.
• W2885442870 citedByCount "14" @default.
• W2885442870 countsByYear W28854428702019 @default.
• W2885442870 countsByYear W28854428702020 @default.
• W2885442870 countsByYear W28854428702022 @default.
• W2885442870 countsByYear W28854428702023 @default.
• W2885442870 crossrefType "journal-article" @default.
• W2885442870 hasAuthorship W2885442870A5001656619 @default.
• W2885442870 hasAuthorship W2885442870A5056397454 @default.
• W2885442870 hasAuthorship W2885442870A5072073786 @default.
• W2885442870 hasAuthorship W2885442870A5079950699 @default.
• W2885442870 hasBestOaLocation W28854428701 @default.
• W2885442870 hasConcept C104317684 @default.
• W2885442870 hasConcept C121446783 @default.
• W2885442870 hasConcept C126322002 @default.
• W2885442870 hasConcept C127561419 @default.
• W2885442870 hasConcept C134018914 @default.
• W2885442870 hasConcept C2777391703 @default.
• W2885442870 hasConcept C2777499176 @default.
• W2885442870 hasConcept C2778764654 @default.
• W2885442870 hasConcept C3018667095 @default.
• W2885442870 hasConcept C38606739 @default.
• W2885442870 hasConcept C55493867 @default.
• W2885442870 hasConcept C555293320 @default.
• W2885442870 hasConcept C63645605 @default.
• W2885442870 hasConcept C71924100 @default.
• W2885442870 hasConcept C86803240 @default.
• W2885442870 hasConceptScore W2885442870C104317684 @default.
• W2885442870 hasConceptScore W2885442870C121446783 @default.
• W2885442870 hasConceptScore W2885442870C126322002 @default.
• W2885442870 hasConceptScore W2885442870C127561419 @default.
• W2885442870 hasConceptScore W2885442870C134018914 @default.
• W2885442870 hasConceptScore W2885442870C2777391703 @default.
• W2885442870 hasConceptScore W2885442870C2777499176 @default.
• W2885442870 hasConceptScore W2885442870C2778764654 @default.

• next