Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885445035> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2885445035 abstract "Background: Postoperative atrial fibrillation (PAF) is a frequent complication following cardiothoracic surgery and is associated with increased length of stay and increased morbidity. This study develops a novel multi-factorial computational model to predict PAF, as well as a simplified risk score for PAF based on this model. Methods: A multi-factorial computational model to predict PAF was trained on 592 patients in the MIMIC II database undergoing cardiothoracic surgery at the Beth Israel Deaconess Medical Center, using demographic, comorbidity, laboratory, and echocardiographic parameters. Parameters were chosen using LR stepwise-backward elimination applied to routinely collected covariates via logistic regression. A simplified risk score was created using the retained covariates based on the observed odds ratios (OR). Discrimination for both the model and risk score were calculated using the area under the receiver operating characteristic curve (AUC) via leave one out cross validation. Results: The multi-factorial computational model retained the following parameters: age in years (OR 1.06; p<0.001), serum chloride in mEq/L (OR 0.92; p=0.019), and left atrial diameter categorized from 0-3 (OR 1.84; p<0.001). The model achieved a significantly higher level of discrimination relative to any covariate alone (AUC 0.72; p<0.001 relative to all individual covariates). The simplified risk score is calculated as: +2 for age > 67, +1 for serum chloride < 105, +1 for each categorical increase in left atrial diameter (>40mm, >47.5mm, >52.5mm); and achieved comparable performance to the multi-factorial computational model (AUC 0.71; p<0.001) with a graded increase in risk (Figure). Conclusions: Multi-factorial computational modeling may provide a robust basis for discriminating between patients at high or low risk of PAF following cardiothoracic surgery. This model can be delivered as a simplified multi-factorial risk score for broad use by the bedside." @default.
- W2885445035 created "2018-08-22" @default.
- W2885445035 creator A5002767754 @default.
- W2885445035 creator A5046052093 @default.
- W2885445035 creator A5057435618 @default.
- W2885445035 creator A5062843392 @default.
- W2885445035 date "2015-11-10" @default.
- W2885445035 modified "2023-09-24" @default.
- W2885445035 title "Abstract 18186: Evaluating the Utility of a Multi-factorial Computational Model and Simplified Multi-factorial Risk Score to Predict Postoperative Atrial Fibrillation Following Cardiothoracic Surgery" @default.
- W2885445035 doi "https://doi.org/10.1161/circ.132.suppl_3.18186" @default.
- W2885445035 hasPublicationYear "2015" @default.
- W2885445035 type Work @default.
- W2885445035 sameAs 2885445035 @default.
- W2885445035 citedByCount "0" @default.
- W2885445035 crossrefType "journal-article" @default.
- W2885445035 hasAuthorship W2885445035A5002767754 @default.
- W2885445035 hasAuthorship W2885445035A5046052093 @default.
- W2885445035 hasAuthorship W2885445035A5057435618 @default.
- W2885445035 hasAuthorship W2885445035A5062843392 @default.
- W2885445035 hasConcept C105795698 @default.
- W2885445035 hasConcept C119043178 @default.
- W2885445035 hasConcept C126322002 @default.
- W2885445035 hasConcept C141071460 @default.
- W2885445035 hasConcept C151956035 @default.
- W2885445035 hasConcept C160022790 @default.
- W2885445035 hasConcept C164705383 @default.
- W2885445035 hasConcept C170964787 @default.
- W2885445035 hasConcept C2779159551 @default.
- W2885445035 hasConcept C2779161974 @default.
- W2885445035 hasConcept C33923547 @default.
- W2885445035 hasConcept C58471807 @default.
- W2885445035 hasConcept C71924100 @default.
- W2885445035 hasConceptScore W2885445035C105795698 @default.
- W2885445035 hasConceptScore W2885445035C119043178 @default.
- W2885445035 hasConceptScore W2885445035C126322002 @default.
- W2885445035 hasConceptScore W2885445035C141071460 @default.
- W2885445035 hasConceptScore W2885445035C151956035 @default.
- W2885445035 hasConceptScore W2885445035C160022790 @default.
- W2885445035 hasConceptScore W2885445035C164705383 @default.
- W2885445035 hasConceptScore W2885445035C170964787 @default.
- W2885445035 hasConceptScore W2885445035C2779159551 @default.
- W2885445035 hasConceptScore W2885445035C2779161974 @default.
- W2885445035 hasConceptScore W2885445035C33923547 @default.
- W2885445035 hasConceptScore W2885445035C58471807 @default.
- W2885445035 hasConceptScore W2885445035C71924100 @default.
- W2885445035 hasIssue "suppl_3" @default.
- W2885445035 hasLocation W28854450351 @default.
- W2885445035 hasOpenAccess W2885445035 @default.
- W2885445035 hasPrimaryLocation W28854450351 @default.
- W2885445035 hasRelatedWork W2038267900 @default.
- W2885445035 hasRelatedWork W2162424199 @default.
- W2885445035 hasRelatedWork W2382691779 @default.
- W2885445035 hasRelatedWork W2383868857 @default.
- W2885445035 hasRelatedWork W2546678507 @default.
- W2885445035 hasRelatedWork W2911561645 @default.
- W2885445035 hasRelatedWork W2918243842 @default.
- W2885445035 hasRelatedWork W2972896016 @default.
- W2885445035 hasRelatedWork W4211144354 @default.
- W2885445035 hasRelatedWork W2182249798 @default.
- W2885445035 hasVolume "132" @default.
- W2885445035 isParatext "false" @default.
- W2885445035 isRetracted "false" @default.
- W2885445035 magId "2885445035" @default.
- W2885445035 workType "article" @default.