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- W2885451302 abstract "Objective—Vascular endothelial growth factor receptor(VEGFR)-3 is a critical regulator of developmental and adult vasculogenesis and lymphangiogenesis through its interactions with select members of the VEGF family. The goal of this study was to investigate how VEGFR-3 expression is regulated during inflammatory lymphangiogenesis. Methods and Results—In this study, we present for the first time evidence that VEGFR-3 can be negatively regulated by a mirtron, hsa-miR–1236 (miR-1236), which is expressed in primary human lymphatic endothelial cells. In human lymphatic endothelial cells, miR-1236 is upregulated in response to IL-1β, a negative regulator of VEGFR-3. miR-1236 binds the 3' untranslated region of Vegfr3, resulting in translational inhibition. Overexpression of miR-1236 significantly decreased expression of VEGFR-3, but not VEGFR-2, in human lymphatic endothelial cells. Compared to a control miR, overexpression of miR-1236 also led to decreased VEGFR-3 signaling. However, VEGFR-2–specific signaling..." @default.
- W2885451302 created "2018-08-22" @default.
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- W2885451302 date "2012-03-01" @default.
- W2885451302 modified "2023-09-28" @default.
- W2885451302 title "Mirtron MicroRNA-1236 Inhibits VEGFR-3 Signaling During Inflammatory Lymphangiogenesis" @default.
- W2885451302 hasPublicationYear "2012" @default.
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