FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885452802> ?p ?o ?g. }

• W2885452802 endingPage "15207" @default.
• W2885452802 startingPage "15195" @default.
• W2885452802 abstract "Toll-like receptors (TLRs) form part of the host innate immune system, in which they act as sensors of microbial and endogenous danger signals. Upon TLR activation, the intracellular Toll/interleukin-1 receptor domains of TLR dimers initiate oligomerization of a multiprotein signaling platform comprising myeloid differentiation primary response 88 (MyD88) and members of the interleukin-1 receptor-associated kinase (IRAK) family. Formation of this myddosome complex initiates signal transduction pathways, leading to the activation of transcription factors and the production of inflammatory cytokines. To date, little is known about the assembly and disassembly of the myddosome and about the mechanisms by which these complexes mediate multiple downstream signaling pathways. Here, we isolated myddosome complexes from whole-cell lysates of TLR-activated primary mouse macrophages and from IRAK reporter macrophages to examine the kinetics of myddosome assembly and disassembly. Using a selective inhibitor of IRAK4's kinase activity, we found that whereas TLR cytokine responses were ablated, myddosome formation was stabilized in the absence of IRAK4's kinase activity. Of note, IRAK4 inhibition had only a minimal effect on NF-κB and mitogen-activated protein kinase (MAPK) signaling. In summary, our results indicate that IRAK4 has a critical scaffold function in myddosome formation and that its kinase activity is dispensable for myddosome assembly and activation of the NF-κB and MAPK pathways but is essential for MyD88-dependent production of inflammatory cytokines. Our findings suggest that the scaffold function of IRAK4 may be an attractive target for treating inflammatory and autoimmune diseases." @default.
• W2885452802 created "2018-08-22" @default.
• W2885452802 creator A5004778423 @default.
• W2885452802 creator A5009349672 @default.
• W2885452802 creator A5055430098 @default.
• W2885452802 creator A5065055789 @default.
• W2885452802 creator A5073962416 @default.
• W2885452802 creator A5073964958 @default.
• W2885452802 date "2018-09-01" @default.
• W2885452802 modified "2023-10-16" @default.
• W2885452802 title "Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling" @default.
• W2885452802 cites W1580600824 @default.
• W2885452802 cites W1765013689 @default.
• W2885452802 cites W1963751749 @default.
• W2885452802 cites W1964985092 @default.
• W2885452802 cites W1965658052 @default.
• W2885452802 cites W1968336033 @default.
• W2885452802 cites W1969501356 @default.
• W2885452802 cites W1993211211 @default.
• W2885452802 cites W1999286245 @default.
• W2885452802 cites W2004986546 @default.
• W2885452802 cites W2013205499 @default.
• W2885452802 cites W2015263036 @default.
• W2885452802 cites W2025124540 @default.
• W2885452802 cites W2031084334 @default.
• W2885452802 cites W2032972084 @default.
• W2885452802 cites W2033735518 @default.
• W2885452802 cites W2034172192 @default.
• W2885452802 cites W2043981380 @default.
• W2885452802 cites W2065262396 @default.
• W2885452802 cites W2066205838 @default.
• W2885452802 cites W2068031486 @default.
• W2885452802 cites W2082996493 @default.
• W2885452802 cites W2111428445 @default.
• W2885452802 cites W2116382435 @default.
• W2885452802 cites W2118224132 @default.
• W2885452802 cites W2119747146 @default.
• W2885452802 cites W2121830340 @default.
• W2885452802 cites W2141040025 @default.
• W2885452802 cites W2141150979 @default.
• W2885452802 cites W2151993654 @default.
• W2885452802 cites W2161241326 @default.
• W2885452802 cites W2165591553 @default.
• W2885452802 cites W2212076220 @default.
• W2885452802 cites W2230207762 @default.
• W2885452802 cites W2441952840 @default.
• W2885452802 cites W2547781691 @default.
• W2885452802 cites W2555153268 @default.
• W2885452802 cites W2606549900 @default.
• W2885452802 cites W2613042274 @default.
• W2885452802 cites W2616790685 @default.
• W2885452802 cites W2754900431 @default.
• W2885452802 cites W2755753508 @default.
• W2885452802 cites W2769627983 @default.
• W2885452802 cites W2770519197 @default.
• W2885452802 cites W2775690235 @default.
• W2885452802 cites W2784697675 @default.
• W2885452802 cites W2803989981 @default.
• W2885452802 cites W4241949506 @default.
• W2885452802 doi "https://doi.org/10.1074/jbc.ra118.003314" @default.
• W2885452802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6166714" @default.
• W2885452802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30076215" @default.
• W2885452802 hasPublicationYear "2018" @default.
• W2885452802 type Work @default.
• W2885452802 sameAs 2885452802 @default.
• W2885452802 citedByCount "71" @default.
• W2885452802 countsByYear W28854528022018 @default.
• W2885452802 countsByYear W28854528022019 @default.
• W2885452802 countsByYear W28854528022020 @default.
• W2885452802 countsByYear W28854528022021 @default.
• W2885452802 countsByYear W28854528022022 @default.
• W2885452802 countsByYear W28854528022023 @default.
• W2885452802 crossrefType "journal-article" @default.
• W2885452802 hasAuthorship W2885452802A5004778423 @default.
• W2885452802 hasAuthorship W2885452802A5009349672 @default.
• W2885452802 hasAuthorship W2885452802A5055430098 @default.
• W2885452802 hasAuthorship W2885452802A5065055789 @default.
• W2885452802 hasAuthorship W2885452802A5073962416 @default.
• W2885452802 hasAuthorship W2885452802A5073964958 @default.
• W2885452802 hasBestOaLocation W28854528021 @default.
• W2885452802 hasConcept C136449434 @default.
• W2885452802 hasConcept C170493617 @default.
• W2885452802 hasConcept C184235292 @default.
• W2885452802 hasConcept C2776709828 @default.
• W2885452802 hasConcept C55493867 @default.
• W2885452802 hasConcept C57074206 @default.
• W2885452802 hasConcept C62478195 @default.
• W2885452802 hasConcept C86803240 @default.
• W2885452802 hasConcept C95444343 @default.
• W2885452802 hasConceptScore W2885452802C136449434 @default.
• W2885452802 hasConceptScore W2885452802C170493617 @default.
• W2885452802 hasConceptScore W2885452802C184235292 @default.
• W2885452802 hasConceptScore W2885452802C2776709828 @default.
• W2885452802 hasConceptScore W2885452802C55493867 @default.
• W2885452802 hasConceptScore W2885452802C57074206 @default.
• W2885452802 hasConceptScore W2885452802C62478195 @default.
• W2885452802 hasConceptScore W2885452802C86803240 @default.
• W2885452802 hasConceptScore W2885452802C95444343 @default.

• next