FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885455522> ?p ?o ?g. }

• W2885455522 endingPage "290" @default.
• W2885455522 startingPage "265" @default.
• W2885455522 abstract "Most living tissues are composite materials with highly nonuniform material properties. Their structure and composition vary from point to point. There are also changes in strength and stiffness, with age and disease condition, which affect the biological function of the tissue. Therefore, the knowledge of tissue mechanical properties on the nano/micro scales is critically important. We have developed an approach to extract the elastic moduli of highly inhomogeneous biological tissues with surface defects that cannot be well characterized. The robustness of our method is illustrated on the example of cartilage extracellular matrix. The tissue was mildly crosslinked to prevent proteoglycan loss due to diffusion occurring upon tissue slicing. Thin tissue slices (~12 μm) have a poorly defined surface layer due to the damage and stress release caused by sectioning. Under indentation forces, the tissue exhibits apparent strain-stiffening, an artifact of the presence of this layer. Therefore, this layer must be accounted for if the properties of the intact, bulk matrix are to be correctly probed. To separate out the effect of this damaged layer, we used large indentations with the mechanics model for finite sample thickness and included an additional constant force contribution from the surface layer as well as the contact point of the underlying intact layer as fitting parameters. This in effect is equivalent to allowing for the existence of an effectivecontact point that is computed as a best-fit parameter. By not forcing the fitted contact point to be on the force curve and by applying larger indentations, we obtain the elasticity of an equivalent material undergoing similar indentation but having a smooth, undamaged surface. Such an approach not only gave us an elasticity modulus that remained unchanged with indentation depth, but also had good correlation across length scales. This explains previous observations that the Hertz model cannot satisfactorily probe matrix mechanics and instead, large deformation models need to be employed (Lin et.al, Biomech. Model. Mechanobiol., 2009). Comparing the contributions from the intact matrix alone, we found that the cartilage stiffness increases towards the resting zone but decreases in the proliferative zone, even though the chemical composition does not change significantly between these regions." @default.
• W2885455522 created "2018-08-22" @default.
• W2885455522 creator A5020127992 @default.
• W2885455522 creator A5038994213 @default.
• W2885455522 creator A5045586055 @default.
• W2885455522 creator A5063070174 @default.
• W2885455522 date "2018-01-01" @default.
• W2885455522 modified "2023-09-25" @default.
• W2885455522 title "A Nanoindentation Approach To Assess the Mechanical Properties of Heterogeneous Biological Tissues with Poorly Defined Surface Characteristics" @default.
• W2885455522 cites W1577690428 @default.
• W2885455522 cites W1582152210 @default.
• W2885455522 cites W1709880564 @default.
• W2885455522 cites W1974509147 @default.
• W2885455522 cites W1979384001 @default.
• W2885455522 cites W1979837737 @default.
• W2885455522 cites W1984251015 @default.
• W2885455522 cites W1986252271 @default.
• W2885455522 cites W1991547220 @default.
• W2885455522 cites W1994718412 @default.
• W2885455522 cites W1998472666 @default.
• W2885455522 cites W2000653022 @default.
• W2885455522 cites W2001918236 @default.
• W2885455522 cites W2011038175 @default.
• W2885455522 cites W2014042137 @default.
• W2885455522 cites W2026056871 @default.
• W2885455522 cites W2027404394 @default.
• W2885455522 cites W2029841137 @default.
• W2885455522 cites W2032824077 @default.
• W2885455522 cites W2033744017 @default.
• W2885455522 cites W2034804863 @default.
• W2885455522 cites W2049521446 @default.
• W2885455522 cites W2054500578 @default.
• W2885455522 cites W2054927713 @default.
• W2885455522 cites W2055699737 @default.
• W2885455522 cites W2063325572 @default.
• W2885455522 cites W2065398254 @default.
• W2885455522 cites W2071571100 @default.
• W2885455522 cites W2071855236 @default.
• W2885455522 cites W2075173045 @default.
• W2885455522 cites W2095504053 @default.
• W2885455522 cites W2104325257 @default.
• W2885455522 cites W2105873482 @default.
• W2885455522 cites W2119581853 @default.
• W2885455522 cites W2150892354 @default.
• W2885455522 cites W2152637989 @default.
• W2885455522 cites W2159542600 @default.
• W2885455522 cites W2159749966 @default.
• W2885455522 cites W2170112920 @default.
• W2885455522 cites W338260045 @default.
• W2885455522 cites W566462862 @default.
• W2885455522 doi "https://doi.org/10.1021/bk-2018-1296.ch014" @default.
• W2885455522 hasPublicationYear "2018" @default.
• W2885455522 type Work @default.
• W2885455522 sameAs 2885455522 @default.
• W2885455522 citedByCount "2" @default.
• W2885455522 countsByYear W28854555222020 @default.
• W2885455522 countsByYear W28854555222022 @default.
• W2885455522 crossrefType "book-chapter" @default.
• W2885455522 hasAuthorship W2885455522A5020127992 @default.
• W2885455522 hasAuthorship W2885455522A5038994213 @default.
• W2885455522 hasAuthorship W2885455522A5045586055 @default.
• W2885455522 hasAuthorship W2885455522A5063070174 @default.
• W2885455522 hasConcept C121854251 @default.
• W2885455522 hasConcept C127413603 @default.
• W2885455522 hasConcept C135628077 @default.
• W2885455522 hasConcept C136229726 @default.
• W2885455522 hasConcept C159985019 @default.
• W2885455522 hasConcept C179909247 @default.
• W2885455522 hasConcept C185592680 @default.
• W2885455522 hasConcept C186541917 @default.
• W2885455522 hasConcept C189165786 @default.
• W2885455522 hasConcept C192562407 @default.
• W2885455522 hasConcept C2779372316 @default.
• W2885455522 hasConcept C2780902562 @default.
• W2885455522 hasConcept C31555180 @default.
• W2885455522 hasConcept C43486711 @default.
• W2885455522 hasConcept C49326732 @default.
• W2885455522 hasConcept C55493867 @default.
• W2885455522 hasConcept C66938386 @default.
• W2885455522 hasConcept C71924100 @default.
• W2885455522 hasConceptScore W2885455522C121854251 @default.
• W2885455522 hasConceptScore W2885455522C127413603 @default.
• W2885455522 hasConceptScore W2885455522C135628077 @default.
• W2885455522 hasConceptScore W2885455522C136229726 @default.
• W2885455522 hasConceptScore W2885455522C159985019 @default.
• W2885455522 hasConceptScore W2885455522C179909247 @default.
• W2885455522 hasConceptScore W2885455522C185592680 @default.
• W2885455522 hasConceptScore W2885455522C186541917 @default.
• W2885455522 hasConceptScore W2885455522C189165786 @default.
• W2885455522 hasConceptScore W2885455522C192562407 @default.
• W2885455522 hasConceptScore W2885455522C2779372316 @default.
• W2885455522 hasConceptScore W2885455522C2780902562 @default.
• W2885455522 hasConceptScore W2885455522C31555180 @default.
• W2885455522 hasConceptScore W2885455522C43486711 @default.
• W2885455522 hasConceptScore W2885455522C49326732 @default.
• W2885455522 hasConceptScore W2885455522C55493867 @default.
• W2885455522 hasConceptScore W2885455522C66938386 @default.
• W2885455522 hasConceptScore W2885455522C71924100 @default.

• next