Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885456345> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2885456345 endingPage "131" @default.
- W2885456345 startingPage "12" @default.
- W2885456345 abstract "Although the new second-generation nonsedative antihistamines terfenadine and astemizole were launched as highly selective and specific H(1)-receptor antagonists, they were later found to cause prolongation of the QT-interval and severe cardiac arrhythmias. The prolongation of the QT-interval is caused by the blockade of one or more of the cardiac potassium channels, among which the delayed rectifier I(Kr), encoded by the HERG-gene, appears to be the most significant. The potency of the prokinetic drug cisapride to block I(Kr) appears to be similar to that of terfenadine (IC(50) about 50 nmol/l). These drugs cause problems when overdosed, used in combination with inhibitors of their CYP3A4-mediated metabolism, or when given to individuals with altered drug kinetics (the aged) or patients with existing cardiac disease (congenitally long QT). Moreover, interactions with other QT-interval prolonging drugs require special attention. Active hydrophilic metabolites of the second-generation antihistaminic compounds (ebastine-carebastine, loratadine-desloratadine, terfenadine-fexofenadine, astemizole-norastemizole) are new compounds with probably reduced risk for drug interactions and cardiac toxicity." @default.
- W2885456345 created "2018-08-22" @default.
- W2885456345 creator A5001546320 @default.
- W2885456345 date "2001-03-16" @default.
- W2885456345 modified "2023-09-27" @default.
- W2885456345 title "Cardiotoxicity of new antihistamines and cisapride" @default.
- W2885456345 hasPublicationYear "2001" @default.
- W2885456345 type Work @default.
- W2885456345 sameAs 2885456345 @default.
- W2885456345 citedByCount "0" @default.
- W2885456345 crossrefType "journal-article" @default.
- W2885456345 hasAuthorship W2885456345A5001546320 @default.
- W2885456345 hasConcept C118441451 @default.
- W2885456345 hasConcept C126322002 @default.
- W2885456345 hasConcept C2776119469 @default.
- W2885456345 hasConcept C2776129107 @default.
- W2885456345 hasConcept C2776711289 @default.
- W2885456345 hasConcept C2777796741 @default.
- W2885456345 hasConcept C2778233292 @default.
- W2885456345 hasConcept C2779177932 @default.
- W2885456345 hasConcept C2779303165 @default.
- W2885456345 hasConcept C2779362680 @default.
- W2885456345 hasConcept C2779703243 @default.
- W2885456345 hasConcept C2780734495 @default.
- W2885456345 hasConcept C29730261 @default.
- W2885456345 hasConcept C42219234 @default.
- W2885456345 hasConcept C71924100 @default.
- W2885456345 hasConcept C83743174 @default.
- W2885456345 hasConcept C98274493 @default.
- W2885456345 hasConceptScore W2885456345C118441451 @default.
- W2885456345 hasConceptScore W2885456345C126322002 @default.
- W2885456345 hasConceptScore W2885456345C2776119469 @default.
- W2885456345 hasConceptScore W2885456345C2776129107 @default.
- W2885456345 hasConceptScore W2885456345C2776711289 @default.
- W2885456345 hasConceptScore W2885456345C2777796741 @default.
- W2885456345 hasConceptScore W2885456345C2778233292 @default.
- W2885456345 hasConceptScore W2885456345C2779177932 @default.
- W2885456345 hasConceptScore W2885456345C2779303165 @default.
- W2885456345 hasConceptScore W2885456345C2779362680 @default.
- W2885456345 hasConceptScore W2885456345C2779703243 @default.
- W2885456345 hasConceptScore W2885456345C2780734495 @default.
- W2885456345 hasConceptScore W2885456345C29730261 @default.
- W2885456345 hasConceptScore W2885456345C42219234 @default.
- W2885456345 hasConceptScore W2885456345C71924100 @default.
- W2885456345 hasConceptScore W2885456345C83743174 @default.
- W2885456345 hasConceptScore W2885456345C98274493 @default.
- W2885456345 hasLocation W28854563451 @default.
- W2885456345 hasOpenAccess W2885456345 @default.
- W2885456345 hasPrimaryLocation W28854563451 @default.
- W2885456345 hasRelatedWork W10330520 @default.
- W2885456345 hasRelatedWork W1520982738 @default.
- W2885456345 hasRelatedWork W1795377301 @default.
- W2885456345 hasRelatedWork W1965532524 @default.
- W2885456345 hasRelatedWork W1966258408 @default.
- W2885456345 hasRelatedWork W1968304609 @default.
- W2885456345 hasRelatedWork W1976455294 @default.
- W2885456345 hasRelatedWork W1990167765 @default.
- W2885456345 hasRelatedWork W2031694304 @default.
- W2885456345 hasRelatedWork W2036224357 @default.
- W2885456345 hasRelatedWork W2041066418 @default.
- W2885456345 hasRelatedWork W2052085254 @default.
- W2885456345 hasRelatedWork W2067534618 @default.
- W2885456345 hasRelatedWork W2079257228 @default.
- W2885456345 hasRelatedWork W2089409514 @default.
- W2885456345 hasRelatedWork W2139252947 @default.
- W2885456345 hasRelatedWork W2143672881 @default.
- W2885456345 hasRelatedWork W2249614687 @default.
- W2885456345 hasRelatedWork W2325738183 @default.
- W2885456345 hasRelatedWork W2410082932 @default.
- W2885456345 hasVolume "1" @default.
- W2885456345 isParatext "false" @default.
- W2885456345 isRetracted "false" @default.
- W2885456345 magId "2885456345" @default.
- W2885456345 workType "article" @default.