Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885459215> ?p ?o ?g. }
- W2885459215 endingPage "299" @default.
- W2885459215 startingPage "273" @default.
- W2885459215 abstract "The G protein-coupled receptor (GPCR) superfamily activates complex signal pathways, yet untangling these signaling systems to understand how specificity in receptor signaling pathways is achieved, has been a challenging question. The roles of membrane trafficking in GPCR signal regulation has undergone a recent paradigm shift, from a mechanism that programs the plasma membrane G protein signaling profile to providing distinct signaling platforms critical for specifying receptor function in vivo. In this chapter, we discuss this evolution of our understanding in the endocytic trafficking systems employed by GPCRs, and how such systems play a deeply integrated role with signaling. We describe recent studies that suggest that the endomembrane compartment can provide a mechanism to both specify, and yet also diversify, GPCR signal transduction. These new evolving models could aid mechanistic understanding of complex disease and provide novel therapeutic avenues." @default.
- W2885459215 created "2018-08-22" @default.
- W2885459215 creator A5014937175 @default.
- W2885459215 creator A5050201115 @default.
- W2885459215 date "2018-01-01" @default.
- W2885459215 modified "2023-10-14" @default.
- W2885459215 title "Evolving View of Membrane Trafficking and Signaling Systems for G Protein-Coupled Receptors" @default.
- W2885459215 cites W118955735 @default.
- W2885459215 cites W1498784784 @default.
- W2885459215 cites W1507084693 @default.
- W2885459215 cites W1933410007 @default.
- W2885459215 cites W1938630352 @default.
- W2885459215 cites W1965518769 @default.
- W2885459215 cites W1966201474 @default.
- W2885459215 cites W1968578345 @default.
- W2885459215 cites W1969464978 @default.
- W2885459215 cites W1981653194 @default.
- W2885459215 cites W1982559827 @default.
- W2885459215 cites W1986170864 @default.
- W2885459215 cites W1986404316 @default.
- W2885459215 cites W1987038656 @default.
- W2885459215 cites W1987559120 @default.
- W2885459215 cites W1990165731 @default.
- W2885459215 cites W1991791520 @default.
- W2885459215 cites W1993840914 @default.
- W2885459215 cites W1994287472 @default.
- W2885459215 cites W1996331981 @default.
- W2885459215 cites W1996678144 @default.
- W2885459215 cites W1998292458 @default.
- W2885459215 cites W2001609281 @default.
- W2885459215 cites W2005718392 @default.
- W2885459215 cites W2007852946 @default.
- W2885459215 cites W2011033953 @default.
- W2885459215 cites W2015614032 @default.
- W2885459215 cites W2017633690 @default.
- W2885459215 cites W2022294588 @default.
- W2885459215 cites W2027639590 @default.
- W2885459215 cites W2027832797 @default.
- W2885459215 cites W2031393760 @default.
- W2885459215 cites W2035568724 @default.
- W2885459215 cites W2038410772 @default.
- W2885459215 cites W2040415055 @default.
- W2885459215 cites W2042698502 @default.
- W2885459215 cites W2049253479 @default.
- W2885459215 cites W2054883747 @default.
- W2885459215 cites W2060346226 @default.
- W2885459215 cites W2061098391 @default.
- W2885459215 cites W2067080420 @default.
- W2885459215 cites W2067166210 @default.
- W2885459215 cites W2067826980 @default.
- W2885459215 cites W2069006856 @default.
- W2885459215 cites W2071349214 @default.
- W2885459215 cites W2073037108 @default.
- W2885459215 cites W2075214208 @default.
- W2885459215 cites W2080406796 @default.
- W2885459215 cites W2080815758 @default.
- W2885459215 cites W2081739565 @default.
- W2885459215 cites W2082817154 @default.
- W2885459215 cites W2083524592 @default.
- W2885459215 cites W2084939203 @default.
- W2885459215 cites W2085004994 @default.
- W2885459215 cites W2091659381 @default.
- W2885459215 cites W2094013515 @default.
- W2885459215 cites W2103631102 @default.
- W2885459215 cites W2105012896 @default.
- W2885459215 cites W2105079567 @default.
- W2885459215 cites W2109014958 @default.
- W2885459215 cites W2109955944 @default.
- W2885459215 cites W2111373319 @default.
- W2885459215 cites W2116354283 @default.
- W2885459215 cites W2116489432 @default.
- W2885459215 cites W2117754393 @default.
- W2885459215 cites W2119398013 @default.
- W2885459215 cites W2120539487 @default.
- W2885459215 cites W2122339412 @default.
- W2885459215 cites W2127013861 @default.
- W2885459215 cites W2129215906 @default.
- W2885459215 cites W2129384867 @default.
- W2885459215 cites W2137850079 @default.
- W2885459215 cites W2140820666 @default.
- W2885459215 cites W2141777375 @default.
- W2885459215 cites W2141956263 @default.
- W2885459215 cites W2149420045 @default.
- W2885459215 cites W2151312020 @default.
- W2885459215 cites W2154730918 @default.
- W2885459215 cites W2156374977 @default.
- W2885459215 cites W2156556961 @default.
- W2885459215 cites W2161475018 @default.
- W2885459215 cites W2162075138 @default.
- W2885459215 cites W2165345221 @default.
- W2885459215 cites W2165408834 @default.
- W2885459215 cites W2165671231 @default.
- W2885459215 cites W2191622804 @default.
- W2885459215 cites W2240242048 @default.
- W2885459215 cites W2253416145 @default.
- W2885459215 cites W2257485841 @default.
- W2885459215 cites W2262581704 @default.
- W2885459215 cites W2272989235 @default.