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- W2885459788 abstract "Background There is evidence for increased formation of free radicals in patients with hypertension, raising the possibility that NO is inactivated by free radicals, which impairs coronary endothelial function. Therefore, we tested the hypothesis that the antioxidant vitamin C could improve abnormal endothelial function of coronary arteries in patients with hypertension. Methods and Results In 22 hypertensive patients without relevant coronary artery stenoses, endothelium-dependent vascular responses of the left anterior descending coronary artery (LAD) to acetylcholine (0.01, 0.1, and 1.0 μmol/L) were determined before and immediately after intravenous infusion of 3 g vitamin C (17 patients) or placebo (5 patients). In a subgroup of 10 patients, papaverine-induced flow-dependent vasodilation (FDD) was measured before and after vitamin C (5 patients) or placebo (5 patients) infusion. Segmental responses of the coronary artery luminal area were analyzed with quantitative coronary angiography. Before vitami..." @default.
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- W2885459788 date "1997-09-02" @default.
- W2885459788 modified "2023-09-23" @default.
- W2885459788 title "Vitamin C Improves Endothelial Dysfunction of Epicardial Coronary Arteries in Hypertensive Patients" @default.
- W2885459788 hasPublicationYear "1997" @default.
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