FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885476103> ?p ?o ?g. }

• W2885476103 abstract "Sulbactam is an atypical β-lactam medication and reported to be neuroprotective by up-regulating glial glutamate transporter-1 (GLT-1) in rats. The present study was undertaken to study the role of p38 MAPK signal pathway in sulbactam induced up-regulation of GLT-1 expression in astrocytes and anti-ischemic effect. Neuron-astrocyte co-cultures and astrocyte cultures from neonatal Wistar rats were used. Cerebral ischemia was mimicked by oxygen-glucose deprivation (OGD). Hoechst (HO)/propidium iodide (PI) double fluorescence staining and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay were used to evaluate neuronal death and cell viability, respectively. Immunocytochemistry and Western blot were used to detect protein expressions. Sulbactam pre-incubation significantly and dose-dependently prevented neuronal death and decline in cell viability induced by OGD in neuron-astrocyte co-cultures, and upregulated GLT-1 expression in astrocyte cultures endured OGD, which suggested that sulbactam might protect neurons against OGD by up-regulating astrocytic GLT-1 expression. It was further shown that the phosphorylated-p38 MAPK expression in astrocytes was up-regulated after the sulbactam pre-incubation and this up-regulation was moderate in amplitude. Especially, the time course of the up-regulation of phosphorylated-p38 MAPK was obviously earlier than that of GLT-1, which suggested possibility that p38 MAPK might be an upstream signal for GLT-1 up-regulation induced by sulbactam. We further found that SB203580, the specific inhibitor of p38 MAPK, dose-dependently inhibited the GLT-1 up-regulation induced by sulbactam either in non- or OGD-treated astrocytes and the protective effect of sulbactam on co-cultured neurons against OGD. Taken together, it might be concluded that sulbactam protects cerebral neurons against OGD by up-regulating astrocytic GLT-1 expression via p38 MAPK signal pathway." @default.
• W2885476103 created "2018-08-22" @default.
• W2885476103 creator A5003365784 @default.
• W2885476103 creator A5004202908 @default.
• W2885476103 creator A5010581622 @default.
• W2885476103 creator A5022100902 @default.
• W2885476103 creator A5027475930 @default.
• W2885476103 creator A5047999139 @default.
• W2885476103 creator A5053204257 @default.
• W2885476103 date "2018-08-15" @default.
• W2885476103 modified "2023-10-16" @default.
• W2885476103 title "Sulbactam Protects Hippocampal Neurons Against Oxygen-Glucose Deprivation by Up-Regulating Astrocytic GLT-1 via p38 MAPK Signal Pathway" @default.
• W2885476103 cites W1495983806 @default.
• W2885476103 cites W1515334051 @default.
• W2885476103 cites W1549972124 @default.
• W2885476103 cites W1596457615 @default.
• W2885476103 cites W1751748906 @default.
• W2885476103 cites W1824665391 @default.
• W2885476103 cites W1851705678 @default.
• W2885476103 cites W1902750135 @default.
• W2885476103 cites W1913069989 @default.
• W2885476103 cites W1954056141 @default.
• W2885476103 cites W1963844828 @default.
• W2885476103 cites W1966610248 @default.
• W2885476103 cites W1969400861 @default.
• W2885476103 cites W1971456649 @default.
• W2885476103 cites W1971547298 @default.
• W2885476103 cites W1974131493 @default.
• W2885476103 cites W1978361606 @default.
• W2885476103 cites W1986292636 @default.
• W2885476103 cites W1991701465 @default.
• W2885476103 cites W1993814619 @default.
• W2885476103 cites W1994155863 @default.
• W2885476103 cites W1995595961 @default.
• W2885476103 cites W1996405087 @default.
• W2885476103 cites W1998695362 @default.
• W2885476103 cites W2001399809 @default.
• W2885476103 cites W2011588737 @default.
• W2885476103 cites W2013379427 @default.
• W2885476103 cites W2021542157 @default.
• W2885476103 cites W2022914311 @default.
• W2885476103 cites W2023615805 @default.
• W2885476103 cites W2030603527 @default.
• W2885476103 cites W2032731042 @default.
• W2885476103 cites W2034184306 @default.
• W2885476103 cites W2045010231 @default.
• W2885476103 cites W2048130120 @default.
• W2885476103 cites W2051861534 @default.
• W2885476103 cites W2060630008 @default.
• W2885476103 cites W2061001694 @default.
• W2885476103 cites W2061463538 @default.
• W2885476103 cites W2061838604 @default.
• W2885476103 cites W2062422673 @default.
• W2885476103 cites W2067136467 @default.
• W2885476103 cites W2079435750 @default.
• W2885476103 cites W2081096611 @default.
• W2885476103 cites W2083204774 @default.
• W2885476103 cites W2086157846 @default.
• W2885476103 cites W2092394791 @default.
• W2885476103 cites W2094673798 @default.
• W2885476103 cites W2105352752 @default.
• W2885476103 cites W2115217673 @default.
• W2885476103 cites W2121366141 @default.
• W2885476103 cites W2122057254 @default.
• W2885476103 cites W2135385360 @default.
• W2885476103 cites W2149848093 @default.
• W2885476103 cites W2155886387 @default.
• W2885476103 cites W2159528862 @default.
• W2885476103 cites W2166660871 @default.
• W2885476103 cites W2170740112 @default.
• W2885476103 cites W2179641263 @default.
• W2885476103 cites W2187851092 @default.
• W2885476103 cites W2224564419 @default.
• W2885476103 cites W2296669469 @default.
• W2885476103 cites W2402786956 @default.
• W2885476103 cites W2465909802 @default.
• W2885476103 cites W2524656042 @default.
• W2885476103 cites W2564814346 @default.
• W2885476103 cites W2790805946 @default.
• W2885476103 cites W4293775696 @default.
• W2885476103 cites W4361960923 @default.
• W2885476103 doi "https://doi.org/10.3389/fnmol.2018.00281" @default.
• W2885476103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6104165" @default.
• W2885476103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30158854" @default.
• W2885476103 hasPublicationYear "2018" @default.
• W2885476103 type Work @default.
• W2885476103 sameAs 2885476103 @default.
• W2885476103 citedByCount "7" @default.
• W2885476103 countsByYear W28854761032019 @default.
• W2885476103 countsByYear W28854761032020 @default.
• W2885476103 countsByYear W28854761032021 @default.
• W2885476103 countsByYear W28854761032022 @default.
• W2885476103 countsByYear W28854761032023 @default.
• W2885476103 crossrefType "journal-article" @default.
• W2885476103 hasAuthorship W2885476103A5003365784 @default.
• W2885476103 hasAuthorship W2885476103A5004202908 @default.
• W2885476103 hasAuthorship W2885476103A5010581622 @default.
• W2885476103 hasAuthorship W2885476103A5022100902 @default.
• W2885476103 hasAuthorship W2885476103A5027475930 @default.
• W2885476103 hasAuthorship W2885476103A5047999139 @default.

• next