FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885479095> ?p ?o ?g. }

• W2885479095 abstract "The mortality rate due to severe sepsis is approximately 30–60%. Sepsis readily progresses to septic shock and multiple organ dysfunction, representing a significant problem in the pediatric intensive care unit (PICU). The aim of this study was to explore the value of plasma mitochondrial DNA (mtDNA) for early diagnosis and prognosis in children with sepsis. A total of 123 children with sepsis who were hospitalized in the Hunan Children’s Hospital PICU from July 2013 to December 2014 were divided into the general sepsis group (n = 70) and severe sepsis group (n = 53) based on diagnostic standards. An additional 30 children with non-sepsis infection and 30 healthy children were randomly selected as a control group. Patients’ plasma was collected during admission to the PICU. A pediatric critical illness score (PCIS) was also calculated. The plasma mtDNA level was examined using real-time polymerase chain reaction technology, and other parameters including routine laboratory values; blood lactate, procalcitonin (PCT), and C-reactive protein (CRP) levels; and data on survival were collected and compared among the groups. The plasma mtDNA level in the sepsis group than that in the non-sepsis infection and healthy groups. The plasma mtDNA level was significantly higher in the severe sepsis than in the general sepsis group (p < 0.001). A lower PCIS was associated with a higher plasma mtDNA level (p < 0.001). A higher number of organs with dysfunction was associated with higher plasma mtDNA levels (p < 0.001). Plasma mtDNA levels were higher among patients with elevated alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, lactate dehydrogenase, creatine kinase, myoglobin, creatine kinase MB, and troponin than in those with values within the normal range. The mtDNA level was higher among non-survivors than among survivors, and this difference was significant. mtDNA showed a prognostic prediction value similar to that of lactate, PCT, and CRP. Plasma mtDNA levels may be a suitable biomarker for diagnosis and prognosis in children with sepsis." @default.
• W2885479095 created "2018-08-22" @default.
• W2885479095 creator A5011719764 @default.
• W2885479095 creator A5018762161 @default.
• W2885479095 creator A5023263087 @default.
• W2885479095 creator A5031178114 @default.
• W2885479095 creator A5050905535 @default.
• W2885479095 creator A5061998853 @default.
• W2885479095 creator A5075100124 @default.
• W2885479095 creator A5078396276 @default.
• W2885479095 date "2018-08-09" @default.
• W2885479095 modified "2023-10-06" @default.
• W2885479095 title "Use of plasma mitochondrial DNA levels for determining disease severity and prognosis in pediatric sepsis: a case control study" @default.
• W2885479095 cites W1606757718 @default.
• W2885479095 cites W1975198268 @default.
• W2885479095 cites W1987519720 @default.
• W2885479095 cites W1993856476 @default.
• W2885479095 cites W2005896876 @default.
• W2885479095 cites W2007286153 @default.
• W2885479095 cites W2016195600 @default.
• W2885479095 cites W2022279786 @default.
• W2885479095 cites W2037967873 @default.
• W2885479095 cites W2038918129 @default.
• W2885479095 cites W2043223581 @default.
• W2885479095 cites W2063772510 @default.
• W2885479095 cites W2070152614 @default.
• W2885479095 cites W2070816505 @default.
• W2885479095 cites W2083805398 @default.
• W2885479095 cites W2093468893 @default.
• W2885479095 cites W2109130949 @default.
• W2885479095 cites W2113010696 @default.
• W2885479095 cites W2122013546 @default.
• W2885479095 cites W2134219545 @default.
• W2885479095 cites W2137274600 @default.
• W2885479095 cites W2146494489 @default.
• W2885479095 cites W2199780657 @default.
• W2885479095 cites W2205249281 @default.
• W2885479095 cites W2213528571 @default.
• W2885479095 cites W2252493886 @default.
• W2885479095 cites W2318363110 @default.
• W2885479095 cites W2409036188 @default.
• W2885479095 cites W2413838973 @default.
• W2885479095 cites W2434535346 @default.
• W2885479095 cites W2442246762 @default.
• W2885479095 cites W2590051664 @default.
• W2885479095 cites W310451024 @default.
• W2885479095 cites W421489949 @default.
• W2885479095 doi "https://doi.org/10.1186/s12887-018-1239-z" @default.
• W2885479095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6085664" @default.
• W2885479095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30092777" @default.
• W2885479095 hasPublicationYear "2018" @default.
• W2885479095 type Work @default.
• W2885479095 sameAs 2885479095 @default.
• W2885479095 citedByCount "18" @default.
• W2885479095 countsByYear W28854790952020 @default.
• W2885479095 countsByYear W28854790952021 @default.
• W2885479095 countsByYear W28854790952022 @default.
• W2885479095 countsByYear W28854790952023 @default.
• W2885479095 crossrefType "journal-article" @default.
• W2885479095 hasAuthorship W2885479095A5011719764 @default.
• W2885479095 hasAuthorship W2885479095A5018762161 @default.
• W2885479095 hasAuthorship W2885479095A5023263087 @default.
• W2885479095 hasAuthorship W2885479095A5031178114 @default.
• W2885479095 hasAuthorship W2885479095A5050905535 @default.
• W2885479095 hasAuthorship W2885479095A5061998853 @default.
• W2885479095 hasAuthorship W2885479095A5075100124 @default.
• W2885479095 hasAuthorship W2885479095A5078396276 @default.
• W2885479095 hasBestOaLocation W28854790951 @default.
• W2885479095 hasConcept C104317684 @default.
• W2885479095 hasConcept C10936531 @default.
• W2885479095 hasConcept C126322002 @default.
• W2885479095 hasConcept C187212893 @default.
• W2885479095 hasConcept C24586158 @default.
• W2885479095 hasConcept C2776376669 @default.
• W2885479095 hasConcept C2777628635 @default.
• W2885479095 hasConcept C2778384902 @default.
• W2885479095 hasConcept C2778426790 @default.
• W2885479095 hasConcept C2778939556 @default.
• W2885479095 hasConcept C54355233 @default.
• W2885479095 hasConcept C71924100 @default.
• W2885479095 hasConcept C86803240 @default.
• W2885479095 hasConcept C90924648 @default.
• W2885479095 hasConceptScore W2885479095C104317684 @default.
• W2885479095 hasConceptScore W2885479095C10936531 @default.
• W2885479095 hasConceptScore W2885479095C126322002 @default.
• W2885479095 hasConceptScore W2885479095C187212893 @default.
• W2885479095 hasConceptScore W2885479095C24586158 @default.
• W2885479095 hasConceptScore W2885479095C2776376669 @default.
• W2885479095 hasConceptScore W2885479095C2777628635 @default.
• W2885479095 hasConceptScore W2885479095C2778384902 @default.
• W2885479095 hasConceptScore W2885479095C2778426790 @default.
• W2885479095 hasConceptScore W2885479095C2778939556 @default.
• W2885479095 hasConceptScore W2885479095C54355233 @default.
• W2885479095 hasConceptScore W2885479095C71924100 @default.
• W2885479095 hasConceptScore W2885479095C86803240 @default.
• W2885479095 hasConceptScore W2885479095C90924648 @default.
• W2885479095 hasIssue "1" @default.
• W2885479095 hasLocation W28854790951 @default.
• W2885479095 hasLocation W28854790952 @default.
• W2885479095 hasLocation W28854790953 @default.

• next