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• W2885485060 abstract "The anti-cancer anthracycline drug Doxorubicin (Dox) causes cardiotoxicity. We investigated the role of protease-activated receptor 1 (PAR-1) in Dox-induced cardiotoxicity.In vitro experiments revealed that PAR-1 enhanced Dox-induced mitochondrial dysfunction, reactive oxygen species and cell death of cardiac myocytes and cardiac fibroblasts. The contribution of PAR-1 to Dox-induced cardiotoxicity was investigated by subjecting PAR-1-/- mice and PAR-1+/+ mice to acute and chronic exposure to Dox. Heart function was measured by echocardiography. PAR-1-/- mice exhibited significant less cardiac injury and dysfunction compared to PAR-1+/+ mice after acute and chronic Dox administration. PAR-1-/- mice had reduced levels of nitrotyrosine, apoptosis and inflammation in their heart compared to PAR-1+/+ mice. Furthermore, inhibition of PAR-1 in wild-type mice with vorapaxar significantly reduced the acute Dox-induced cardiotoxicity.Our results indicate that activation of PAR-1 contributes to Dox-induced cardiotoxicity. Inhibition of PAR-1 may be a new approach to reduce Dox-induced cardiotoxicity in cancer patients." @default.
• W2885485060 created "2018-08-22" @default.
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• W2885485060 date "2018-09-01" @default.
• W2885485060 modified "2023-10-12" @default.
• W2885485060 title "Protease-activated receptor 1 activation enhances doxorubicin-induced cardiotoxicity" @default.
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• W2885485060 doi "https://doi.org/10.1016/j.yjmcc.2018.08.008" @default.
• W2885485060 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6173317" @default.
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