FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885485619> ?p ?o ?g. }

• W2885485619 abstract "Syngeneic mouse models are the most extensively explored mouse models for evaluation of immune-oncology therapeutic modalities in preclinical settings. One of the major limitations with syngeneic models is that both the tumor and the immune system is murine and thus do not express any human targets. Also, this precludes the evaluation of human clinical product (antibody or protein) mandating the synthesis and use of murine surrogates. Therefore, development of models of human tumors in mice with competent human immunity became an urgent need. Tumor-bearing, humanized NOG-EXL mice are a new and valuable preclinical testing platform for immuno-oncology, to simulate trials, evaluate multiple drugs alone or in combination, and produce predictive data both in cell line derived (CDX) and patient derived (PDX) models. With the objective of understanding the tumor growth and basal immune microenvironment in Hu-NOG-EXL mice (NOG mice humanized using CD34+ cells isolated from cord blood), we implanted three different human tumor cell lines (A549: Human Lung Carcinoma; MDA-MB-436: Triple Negative Breast Cancer; A375: Human Melanoma) in Hu-NOG EXL mice procured from Taconic, NY. The tumors were collected at a tumor volume of 1000-1500mm3, and profiled for the lymphoid and myeloid compartments using flow cytometry. The corresponding splenic compartment was also profiled to monitor the correlation or lack thereof between the tumor and splenic compartments. Finally the tumors were compared and categorized based on their basal infiltrates. The results demonstrated that Hu-NOG-EXL mice could be an useful tool to dissect the immune response in human tumors. It was possible to identify and quantitate the myeloid cells which are absent in a model that has been implanted with human PBMNC9s (Peripheral Blood Mono Nuclear Cells) instead of human CD34 stem cells. Citation Format: Srimoyee Ghosh, Anne Fiore, Christoph Eberle, Sarah Wang, Keith Mikule, Kristen McEachern, Sujatha Kumar, David Jenkins, Geeta Sharma. Characterization of tumor growth and immune microenvironment in humanized NOG-EXL mice implanted with A549, MDA-MB-436 and A375 cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5690." @default.
• W2885485619 created "2018-08-22" @default.
• W2885485619 creator A5001166289 @default.
• W2885485619 creator A5002850153 @default.
• W2885485619 creator A5003095296 @default.
• W2885485619 creator A5024595838 @default.
• W2885485619 creator A5034692076 @default.
• W2885485619 creator A5035696545 @default.
• W2885485619 creator A5053645352 @default.
• W2885485619 creator A5058106142 @default.
• W2885485619 creator A5085430315 @default.
• W2885485619 date "2018-07-01" @default.
• W2885485619 modified "2023-09-25" @default.
• W2885485619 title "Abstract 5690: Characterization of tumor growth and immune microenvironment in humanized NOG-EXL mice implanted with A549, MDA-MB-436 and A375 cells" @default.
• W2885485619 doi "https://doi.org/10.1158/1538-7445.am2018-5690" @default.
• W2885485619 hasPublicationYear "2018" @default.
• W2885485619 type Work @default.
• W2885485619 sameAs 2885485619 @default.
• W2885485619 citedByCount "0" @default.
• W2885485619 crossrefType "proceedings-article" @default.
• W2885485619 hasAuthorship W2885485619A5001166289 @default.
• W2885485619 hasAuthorship W2885485619A5002850153 @default.
• W2885485619 hasAuthorship W2885485619A5003095296 @default.
• W2885485619 hasAuthorship W2885485619A5024595838 @default.
• W2885485619 hasAuthorship W2885485619A5034692076 @default.
• W2885485619 hasAuthorship W2885485619A5035696545 @default.
• W2885485619 hasAuthorship W2885485619A5053645352 @default.
• W2885485619 hasAuthorship W2885485619A5058106142 @default.
• W2885485619 hasAuthorship W2885485619A5085430315 @default.
• W2885485619 hasConcept C121608353 @default.
• W2885485619 hasConcept C126322002 @default.
• W2885485619 hasConcept C203014093 @default.
• W2885485619 hasConcept C2776107976 @default.
• W2885485619 hasConcept C2776156784 @default.
• W2885485619 hasConcept C2779282312 @default.
• W2885485619 hasConcept C502942594 @default.
• W2885485619 hasConcept C71924100 @default.
• W2885485619 hasConcept C8891405 @default.
• W2885485619 hasConceptScore W2885485619C121608353 @default.
• W2885485619 hasConceptScore W2885485619C126322002 @default.
• W2885485619 hasConceptScore W2885485619C203014093 @default.
• W2885485619 hasConceptScore W2885485619C2776107976 @default.
• W2885485619 hasConceptScore W2885485619C2776156784 @default.
• W2885485619 hasConceptScore W2885485619C2779282312 @default.
• W2885485619 hasConceptScore W2885485619C502942594 @default.
• W2885485619 hasConceptScore W2885485619C71924100 @default.
• W2885485619 hasConceptScore W2885485619C8891405 @default.
• W2885485619 hasLocation W28854856191 @default.
• W2885485619 hasOpenAccess W2885485619 @default.
• W2885485619 hasPrimaryLocation W28854856191 @default.
• W2885485619 hasRelatedWork W1997944395 @default.
• W2885485619 hasRelatedWork W2122584026 @default.
• W2885485619 hasRelatedWork W2336565038 @default.
• W2885485619 hasRelatedWork W2504122993 @default.
• W2885485619 hasRelatedWork W2582414407 @default.
• W2885485619 hasRelatedWork W2912621681 @default.
• W2885485619 hasRelatedWork W2952605014 @default.
• W2885485619 hasRelatedWork W3137351506 @default.
• W2885485619 hasRelatedWork W3172495772 @default.
• W2885485619 hasRelatedWork W4206111438 @default.
• W2885485619 isParatext "false" @default.
• W2885485619 isRetracted "false" @default.
• W2885485619 magId "2885485619" @default.
• W2885485619 workType "article" @default.