FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885487637> ?p ?o ?g. }

• W2885487637 abstract "As patients with non‑small cell lung cancer (NSCLC) and wild‑type epidermal growth factor receptor (EGFR) are resistant to treatment with erlotinib or gefitinib, potential chemosensitizers are required to potentiate wild‑type EGFR NSCLC cells to erlotinib/gefitinib treatment. The present study reported that shikonin could sensitize the anticancer activity of erlotinib/gefitinib in wild‑type EGFR NSCLC cells. Furthermore, shikonin could potentiate mitochondrial‑mediated apoptosis induced by erlotinib/gefitinib in wild‑type EGFR NSCLC cells. In addition, the present study demonstrated that shikonin could induce apoptosis by activating reactive oxygen species (ROS)‑mediated endoplasmic reticulum (ER) stress, and that erlotinib/gefitinib may also induce ER stress in wild‑type EGFR NSCLC cells; however, shikonin plus erlotinib/gefitinib was more effective in activating ER stress than either agent alone. This indicated that ROS‑mediated ER stress may be associated with enhanced mitochondrial apoptosis induced by shikonin plus erlotinib/gefitinib. In addition, shikonin may promote the transition of cytoprotective ER stress‑inducing EGFR‑tyrosine kinase inhibitor tolerance to apoptosis‑promoting ER stress. Furthermore, shikonin may enhance the anti‑NSCLC activity of erlotinib/gefitinib in vivo. The data of the present study indicated that shikonin may be a potential sensitizer to enhance the anti‑cancer efficacy of erlotinib/gefitinib in wild‑type EGFR NSCLC cells resistant to erlotinib/gefitinib treatment." @default.
• W2885487637 created "2018-08-22" @default.
• W2885487637 creator A5001466305 @default.
• W2885487637 creator A5002047948 @default.
• W2885487637 creator A5011877804 @default.
• W2885487637 creator A5012413938 @default.
• W2885487637 creator A5047835985 @default.
• W2885487637 creator A5049175271 @default.
• W2885487637 creator A5054183094 @default.
• W2885487637 creator A5086529957 @default.
• W2885487637 creator A5091133225 @default.
• W2885487637 date "2018-08-03" @default.
• W2885487637 modified "2023-10-17" @default.
• W2885487637 title "Shikonin sensitizes wild‑type EGFR NSCLC cells to erlotinib and gefitinib therapy" @default.
• W2885487637 cites W1581625137 @default.
• W2885487637 cites W1976943917 @default.
• W2885487637 cites W1989734503 @default.
• W2885487637 cites W2036976172 @default.
• W2885487637 cites W2065141010 @default.
• W2885487637 cites W2068720063 @default.
• W2885487637 cites W2077945404 @default.
• W2885487637 cites W2080174827 @default.
• W2885487637 cites W2083278580 @default.
• W2885487637 cites W2085933321 @default.
• W2885487637 cites W2104639622 @default.
• W2885487637 cites W2105026490 @default.
• W2885487637 cites W2108053190 @default.
• W2885487637 cites W2108175962 @default.
• W2885487637 cites W2115706326 @default.
• W2885487637 cites W2129558759 @default.
• W2885487637 cites W2140334822 @default.
• W2885487637 cites W2161821474 @default.
• W2885487637 cites W2236479247 @default.
• W2885487637 cites W2326920373 @default.
• W2885487637 cites W2401153021 @default.
• W2885487637 cites W2468983064 @default.
• W2885487637 cites W2469307120 @default.
• W2885487637 cites W2489207582 @default.
• W2885487637 cites W2507889921 @default.
• W2885487637 cites W2520574576 @default.
• W2885487637 cites W2556130581 @default.
• W2885487637 cites W2557422951 @default.
• W2885487637 cites W2559687683 @default.
• W2885487637 cites W2563590437 @default.
• W2885487637 cites W2572671324 @default.
• W2885487637 cites W2606328036 @default.
• W2885487637 cites W2608026191 @default.
• W2885487637 cites W2613740940 @default.
• W2885487637 cites W2622337321 @default.
• W2885487637 cites W2734470318 @default.
• W2885487637 cites W2778954596 @default.
• W2885487637 doi "https://doi.org/10.3892/mmr.2018.9347" @default.
• W2885487637 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6131653" @default.
• W2885487637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30106133" @default.
• W2885487637 hasPublicationYear "2018" @default.
• W2885487637 type Work @default.
• W2885487637 sameAs 2885487637 @default.
• W2885487637 citedByCount "8" @default.
• W2885487637 countsByYear W28854876372020 @default.
• W2885487637 countsByYear W28854876372021 @default.
• W2885487637 countsByYear W28854876372022 @default.
• W2885487637 crossrefType "journal-article" @default.
• W2885487637 hasAuthorship W2885487637A5001466305 @default.
• W2885487637 hasAuthorship W2885487637A5002047948 @default.
• W2885487637 hasAuthorship W2885487637A5011877804 @default.
• W2885487637 hasAuthorship W2885487637A5012413938 @default.
• W2885487637 hasAuthorship W2885487637A5047835985 @default.
• W2885487637 hasAuthorship W2885487637A5049175271 @default.
• W2885487637 hasAuthorship W2885487637A5054183094 @default.
• W2885487637 hasAuthorship W2885487637A5086529957 @default.
• W2885487637 hasAuthorship W2885487637A5091133225 @default.
• W2885487637 hasBestOaLocation W28854876371 @default.
• W2885487637 hasConcept C121608353 @default.
• W2885487637 hasConcept C126322002 @default.
• W2885487637 hasConcept C143998085 @default.
• W2885487637 hasConcept C185592680 @default.
• W2885487637 hasConcept C190283241 @default.
• W2885487637 hasConcept C2776256026 @default.
• W2885487637 hasConcept C2778087573 @default.
• W2885487637 hasConcept C2779438470 @default.
• W2885487637 hasConcept C2780580887 @default.
• W2885487637 hasConcept C2909325608 @default.
• W2885487637 hasConcept C502942594 @default.
• W2885487637 hasConcept C55493867 @default.
• W2885487637 hasConcept C71924100 @default.
• W2885487637 hasConcept C98274493 @default.
• W2885487637 hasConceptScore W2885487637C121608353 @default.
• W2885487637 hasConceptScore W2885487637C126322002 @default.
• W2885487637 hasConceptScore W2885487637C143998085 @default.
• W2885487637 hasConceptScore W2885487637C185592680 @default.
• W2885487637 hasConceptScore W2885487637C190283241 @default.
• W2885487637 hasConceptScore W2885487637C2776256026 @default.
• W2885487637 hasConceptScore W2885487637C2778087573 @default.
• W2885487637 hasConceptScore W2885487637C2779438470 @default.
• W2885487637 hasConceptScore W2885487637C2780580887 @default.
• W2885487637 hasConceptScore W2885487637C2909325608 @default.
• W2885487637 hasConceptScore W2885487637C502942594 @default.
• W2885487637 hasConceptScore W2885487637C55493867 @default.
• W2885487637 hasConceptScore W2885487637C71924100 @default.
• W2885487637 hasConceptScore W2885487637C98274493 @default.

• next