FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885487975> ?p ?o ?g. }

• W2885487975 abstract "Ovarian cancer is a complicated malady associated with cancer stem cells (CSCs) contributing to 238,700 estimated new cases and 151,900 deaths per year, worldwide. CSCs comprise a tiny fraction of tumor-bulk responsible for cancer recurrence and eventual mortality. CSCs or tumor initiating cells are responsible for self-renewal, differentiation and proliferative potential, tumor initiation capability, its progression, drug resistance and metastatic spread. Although several biomarkers are implicated in these processes, their distribution within the ovary and association with single cell type has neither been established nor demonstrated across ovarian tumor developmental stages. Therefore, precise identification, thorough characterization and effective targeted destruction of dormant and highly proliferating potent CSC populations is an immediate need.In view of this, distribution of various CSC (ALDH1/2, C-KIT, CD133, CD24 and CD44) and cell proliferation (KI67) specific markers in the ovarian surface epithelium (OSE) and cortex regions in normal ovary, and benign, borderline and high grade metastatic ovarian tumors by immuno-histochemistry and confocal microscopy was studied. We further confirmed their expression by RT-PCR analysis. Co-expression analysis of stem cell (OCT4, SSEA4) and CSC (ALDH1/2, CD44 and LGR5) markers with proliferation marker (KI67) in HG tumors revealed dual positive proliferating stem and CSCs, few non-proliferating stem/CSC (SSEA4+/KI67- and ALDH1/2+/KI67-) and only KI67+ cells in cortex, signifying dynamic populations and interesting cellular hierarchy in cortex region. Smaller spherical (≤ 5 μm) and larger spindle/elliptical shaped (~ 10 μm) cell populations with high nucleo-cytoplasmic ratio were detected across all samples (including normal ovaries) but with variable distribution and characteristic stage-wise marker expression across different tumor stages.Diverse stem and CSC populations expressing characteristic markers revealing distinct phenotypes (spherical ≤5 μm and spindle/elliptical ~ 10 μm) were distributed within different tumor stages studied signifying dynamic and probable functional hierarchy within these cell types. Involvement of extra-ovarian sites of origin of stem and CSCs requires rigorous evaluation. Quantitative analysis of potent CSC populations, their mechanisms and pathways for self-renewal, chemo-resistance, metastatic spread etc. with respect to various markers studied, will provide better insights and targets for developing effective therapeutics to prevent metastasis and eventually help improve patient mortality." @default.
• W2885487975 created "2018-08-22" @default.
• W2885487975 creator A5026756354 @default.
• W2885487975 creator A5085256777 @default.
• W2885487975 creator A5086717421 @default.
• W2885487975 date "2018-08-18" @default.
• W2885487975 modified "2023-09-27" @default.
• W2885487975 title "Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors" @default.
• W2885487975 cites W119594827 @default.
• W2885487975 cites W1524090337 @default.
• W2885487975 cites W1779339779 @default.
• W2885487975 cites W189620725 @default.
• W2885487975 cites W1943633942 @default.
• W2885487975 cites W1968002492 @default.
• W2885487975 cites W1978695677 @default.
• W2885487975 cites W1979568941 @default.
• W2885487975 cites W1997471695 @default.
• W2885487975 cites W2000537249 @default.
• W2885487975 cites W2003792361 @default.
• W2885487975 cites W2004878973 @default.
• W2885487975 cites W2008893427 @default.
• W2885487975 cites W2016512144 @default.
• W2885487975 cites W2017975901 @default.
• W2885487975 cites W2018360235 @default.
• W2885487975 cites W2030200135 @default.
• W2885487975 cites W2046360871 @default.
• W2885487975 cites W2049839677 @default.
• W2885487975 cites W2054002500 @default.
• W2885487975 cites W2056816232 @default.
• W2885487975 cites W2057528904 @default.
• W2885487975 cites W2062565980 @default.
• W2885487975 cites W2067434109 @default.
• W2885487975 cites W2085000900 @default.
• W2885487975 cites W2089930014 @default.
• W2885487975 cites W2090973422 @default.
• W2885487975 cites W2093631212 @default.
• W2885487975 cites W2094829108 @default.
• W2885487975 cites W2096643870 @default.
• W2885487975 cites W2097099906 @default.
• W2885487975 cites W2118959872 @default.
• W2885487975 cites W2126712477 @default.
• W2885487975 cites W2131440597 @default.
• W2885487975 cites W2137790111 @default.
• W2885487975 cites W2138784667 @default.
• W2885487975 cites W2153682492 @default.
• W2885487975 cites W2156155175 @default.
• W2885487975 cites W2158569602 @default.
• W2885487975 cites W2164916859 @default.
• W2885487975 cites W2170550739 @default.
• W2885487975 cites W2208454568 @default.
• W2885487975 cites W2294335499 @default.
• W2885487975 cites W2312615678 @default.
• W2885487975 cites W2317206393 @default.
• W2885487975 cites W2330191263 @default.
• W2885487975 cites W2405439597 @default.
• W2885487975 cites W2462591873 @default.
• W2885487975 cites W2499438691 @default.
• W2885487975 cites W2517205570 @default.
• W2885487975 cites W2528256323 @default.
• W2885487975 cites W2536978916 @default.
• W2885487975 cites W2569008302 @default.
• W2885487975 cites W2570085465 @default.
• W2885487975 cites W2572955646 @default.
• W2885487975 cites W2574793421 @default.
• W2885487975 cites W2589517913 @default.
• W2885487975 cites W2592356044 @default.
• W2885487975 cites W2596756517 @default.
• W2885487975 cites W2606879285 @default.
• W2885487975 cites W2610320095 @default.
• W2885487975 cites W2611236069 @default.
• W2885487975 cites W2621118520 @default.
• W2885487975 cites W2743335538 @default.
• W2885487975 cites W2765528115 @default.
• W2885487975 cites W2782388893 @default.
• W2885487975 cites W415159368 @default.
• W2885487975 cites W4247653930 @default.
• W2885487975 cites W42771901 @default.
• W2885487975 doi "https://doi.org/10.1186/s13048-018-0439-3" @default.
• W2885487975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6098829" @default.
• W2885487975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30121075" @default.
• W2885487975 hasPublicationYear "2018" @default.
• W2885487975 type Work @default.
• W2885487975 sameAs 2885487975 @default.
• W2885487975 citedByCount "59" @default.
• W2885487975 countsByYear W28854879752019 @default.
• W2885487975 countsByYear W28854879752020 @default.
• W2885487975 countsByYear W28854879752021 @default.
• W2885487975 countsByYear W28854879752022 @default.
• W2885487975 countsByYear W28854879752023 @default.
• W2885487975 crossrefType "journal-article" @default.
• W2885487975 hasAuthorship W2885487975A5026756354 @default.
• W2885487975 hasAuthorship W2885487975A5085256777 @default.
• W2885487975 hasAuthorship W2885487975A5086717421 @default.
• W2885487975 hasBestOaLocation W28854879751 @default.
• W2885487975 hasConcept C10116572 @default.
• W2885487975 hasConcept C104317684 @default.
• W2885487975 hasConcept C121608353 @default.
• W2885487975 hasConcept C134018914 @default.
• W2885487975 hasConcept C136302470 @default.
• W2885487975 hasConcept C142724271 @default.

• next