Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885489762> ?p ?o ?g. }
- W2885489762 abstract "The emergence of zoonotic strains of avian influenza (AI) that cause high rates of mortality in people has caused significant global concern, with a looming threat that one of these strains may develop sustained human-to-human transmission and cause a pandemic outbreak. Most notable of these viral strains are the H5N1 highly pathogenic AI (HPAI) and the H7N9 low pathogenicity AI (LPAI) viruses, both of which have mortality rates above 30%. Understanding of their mechanisms of infection and pathobiology is key to our preparation for these and future viral strains of high consequence. AI viruses typically circulate in wild bird populations, commonly infecting waterfowl and also regularly entering commercial poultry flocks, with live poultry markets providing an ideal environment for the spread AI and potentially the selection of mutants with a greater propensity for infecting humans. Pathology from these infections is primarily driven by a dysregulated immune response, which is characterised by systemic spread of the virus, resulting in lymphopenia and hypercytokinemia. It has been well documented that host/pathogen interactions, particularly molecules of the immune system, play a significant role in both disease susceptibility as well as disease outcome. Here we review the immune/virus interactions in both avian and mammalian species, and provide an overview or our understanding of how immune dysregulation is driven. Understanding these susceptibility factors is critical for the development of new vaccines and therapeutics to combat the next pandemic influenza." @default.
- W2885489762 created "2018-08-22" @default.
- W2885489762 creator A5021917021 @default.
- W2885489762 creator A5022968105 @default.
- W2885489762 creator A5040884230 @default.
- W2885489762 creator A5068293083 @default.
- W2885489762 creator A5080907867 @default.
- W2885489762 date "2018-08-08" @default.
- W2885489762 modified "2023-10-09" @default.
- W2885489762 title "The Drivers of Pathology in Zoonotic Avian Influenza: The Interplay Between Host and Pathogen" @default.
- W2885489762 cites W114652413 @default.
- W2885489762 cites W1759689531 @default.
- W2885489762 cites W1830796224 @default.
- W2885489762 cites W1841413284 @default.
- W2885489762 cites W1908694323 @default.
- W2885489762 cites W1924109658 @default.
- W2885489762 cites W1950627877 @default.
- W2885489762 cites W1958830212 @default.
- W2885489762 cites W1963673812 @default.
- W2885489762 cites W1964381386 @default.
- W2885489762 cites W1971402509 @default.
- W2885489762 cites W1971430559 @default.
- W2885489762 cites W1973122974 @default.
- W2885489762 cites W1975333364 @default.
- W2885489762 cites W1978478590 @default.
- W2885489762 cites W1978658172 @default.
- W2885489762 cites W1981094841 @default.
- W2885489762 cites W1983311886 @default.
- W2885489762 cites W1985007657 @default.
- W2885489762 cites W1986144600 @default.
- W2885489762 cites W1987917595 @default.
- W2885489762 cites W1988436330 @default.
- W2885489762 cites W1988696182 @default.
- W2885489762 cites W1989276269 @default.
- W2885489762 cites W1990581210 @default.
- W2885489762 cites W1990712675 @default.
- W2885489762 cites W1994724597 @default.
- W2885489762 cites W1997677961 @default.
- W2885489762 cites W2000811678 @default.
- W2885489762 cites W2003988251 @default.
- W2885489762 cites W2005855529 @default.
- W2885489762 cites W2009551722 @default.
- W2885489762 cites W2016084887 @default.
- W2885489762 cites W2016508081 @default.
- W2885489762 cites W2017589835 @default.
- W2885489762 cites W2018594231 @default.
- W2885489762 cites W2019769551 @default.
- W2885489762 cites W2021320964 @default.
- W2885489762 cites W2023511584 @default.
- W2885489762 cites W2028170369 @default.
- W2885489762 cites W2034649150 @default.
- W2885489762 cites W2041847917 @default.
- W2885489762 cites W2042726815 @default.
- W2885489762 cites W2042839347 @default.
- W2885489762 cites W2044591518 @default.
- W2885489762 cites W2044594287 @default.
- W2885489762 cites W2045337113 @default.
- W2885489762 cites W2048648611 @default.
- W2885489762 cites W2049505623 @default.
- W2885489762 cites W2050782306 @default.
- W2885489762 cites W2052702884 @default.
- W2885489762 cites W2054801694 @default.
- W2885489762 cites W2058131526 @default.
- W2885489762 cites W2058625773 @default.
- W2885489762 cites W2058760370 @default.
- W2885489762 cites W2062869652 @default.
- W2885489762 cites W2068946828 @default.
- W2885489762 cites W2069439138 @default.
- W2885489762 cites W2072411920 @default.
- W2885489762 cites W2074826023 @default.
- W2885489762 cites W2076216495 @default.
- W2885489762 cites W2078315258 @default.
- W2885489762 cites W2078808862 @default.
- W2885489762 cites W2080857860 @default.
- W2885489762 cites W2081043504 @default.
- W2885489762 cites W2083174112 @default.
- W2885489762 cites W2091839129 @default.
- W2885489762 cites W2104098707 @default.
- W2885489762 cites W2105226322 @default.
- W2885489762 cites W2106173155 @default.
- W2885489762 cites W2106344183 @default.
- W2885489762 cites W2106848220 @default.
- W2885489762 cites W2107231103 @default.
- W2885489762 cites W2112170460 @default.
- W2885489762 cites W2112982331 @default.
- W2885489762 cites W2114960492 @default.
- W2885489762 cites W2117557710 @default.
- W2885489762 cites W2118742454 @default.
- W2885489762 cites W2120113718 @default.
- W2885489762 cites W2123944715 @default.
- W2885489762 cites W2124208765 @default.
- W2885489762 cites W2124429792 @default.
- W2885489762 cites W2125365483 @default.
- W2885489762 cites W2126309815 @default.
- W2885489762 cites W2127186127 @default.
- W2885489762 cites W2127879872 @default.
- W2885489762 cites W2135365914 @default.
- W2885489762 cites W2135659478 @default.
- W2885489762 cites W2136439050 @default.
- W2885489762 cites W2136570341 @default.