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- W2885492789 endingPage "231" @default.
- W2885492789 startingPage "223" @default.
- W2885492789 abstract "Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, has a median overall survival of 6–12 months and a 5-year survival of less than 7%. While PDAC currently represents the 4th most frequent cause of death due to cancer worldwide, it is expected to become the second leading cause of cancer-related death by 2030. These alarming statistics are primarily due to both the inherent chemoresistant and metastatic nature of this tumor, and the existence of a subpopulation of highly plastic “stem”-like cells within the tumor, known as cancer stem cells (CSCs). Since their discovery in PDAC in 2007, we have come to realize that pancreatic CSCs have unique metabolic, autophagic, invasive, and chemoresistance properties that allow them to continuously self-renew and escape chemo-therapeutic elimination. More importantly, the concept of the CSC as a fixed entity within the tumor has also evolved, and current data suggest that CSCs are states rather than defined entities. Consequently, current treatments for the majority of PDAC patients are not effective, and do not significantly impact overall patient survival, as they do not adequately target the plastic CSC sub-population nor the transient/hybrid cells that can replenish the CSC pool. Thus, it is necessary that we improve our understanding of the characteristics and signals that maintain and drive the pancreatic CSC population in order to develop new therapies to target these cells. Herein, we will provide the latest updates and knowledge on the inherent characteristics of pancreatic CSCs and the CSC niche, specifically the cross-talk that exists between CSCs and niche resident cells. Lastly, we will address the question of whether a CSC is a state or an entity and discuss how the answer to this question can impact treatment approaches." @default.
- W2885492789 created "2018-08-22" @default.
- W2885492789 creator A5031406092 @default.
- W2885492789 creator A5056191434 @default.
- W2885492789 date "2018-12-01" @default.
- W2885492789 modified "2023-10-18" @default.
- W2885492789 title "Pancreatic cancer stem cells: A state or an entity?" @default.
- W2885492789 cites W1504049064 @default.
- W2885492789 cites W1601810087 @default.
- W2885492789 cites W1732736480 @default.
- W2885492789 cites W1892036645 @default.
- W2885492789 cites W1931508686 @default.
- W2885492789 cites W1966285323 @default.
- W2885492789 cites W1967952222 @default.
- W2885492789 cites W1968812902 @default.
- W2885492789 cites W1971095929 @default.
- W2885492789 cites W1974225259 @default.
- W2885492789 cites W1984564310 @default.
- W2885492789 cites W1985780641 @default.
- W2885492789 cites W1988783376 @default.
- W2885492789 cites W1994599132 @default.
- W2885492789 cites W1994928797 @default.
- W2885492789 cites W2001258296 @default.
- W2885492789 cites W2001544973 @default.
- W2885492789 cites W2001717792 @default.
- W2885492789 cites W2004419844 @default.
- W2885492789 cites W2004455131 @default.
- W2885492789 cites W2007107031 @default.
- W2885492789 cites W2011807945 @default.
- W2885492789 cites W2011982648 @default.
- W2885492789 cites W2016006035 @default.
- W2885492789 cites W2016699821 @default.
- W2885492789 cites W2017887437 @default.
- W2885492789 cites W2019264784 @default.
- W2885492789 cites W2020738127 @default.
- W2885492789 cites W2023427658 @default.
- W2885492789 cites W2029231546 @default.
- W2885492789 cites W2029443168 @default.
- W2885492789 cites W2033329729 @default.
- W2885492789 cites W2035598662 @default.
- W2885492789 cites W2039813669 @default.
- W2885492789 cites W2040695321 @default.
- W2885492789 cites W2042397019 @default.
- W2885492789 cites W2043772256 @default.
- W2885492789 cites W2046577405 @default.
- W2885492789 cites W2051055358 @default.
- W2885492789 cites W2057036075 @default.
- W2885492789 cites W2060722835 @default.
- W2885492789 cites W2062809449 @default.
- W2885492789 cites W2064578746 @default.
- W2885492789 cites W2065220128 @default.
- W2885492789 cites W2065941404 @default.
- W2885492789 cites W2066362124 @default.
- W2885492789 cites W2066469619 @default.
- W2885492789 cites W2069064270 @default.
- W2885492789 cites W2071123870 @default.
- W2885492789 cites W2072525040 @default.
- W2885492789 cites W2073514136 @default.
- W2885492789 cites W2078510083 @default.
- W2885492789 cites W2081447858 @default.
- W2885492789 cites W2082903419 @default.
- W2885492789 cites W2085786848 @default.
- W2885492789 cites W2087120053 @default.
- W2885492789 cites W2089294608 @default.
- W2885492789 cites W2090982381 @default.
- W2885492789 cites W2091506777 @default.
- W2885492789 cites W2094735859 @default.
- W2885492789 cites W2100519108 @default.
- W2885492789 cites W2100559817 @default.
- W2885492789 cites W2103944466 @default.
- W2885492789 cites W2104666893 @default.
- W2885492789 cites W2116554142 @default.
- W2885492789 cites W2129375080 @default.
- W2885492789 cites W2129584756 @default.
- W2885492789 cites W2131170195 @default.
- W2885492789 cites W2136107102 @default.
- W2885492789 cites W2138784667 @default.
- W2885492789 cites W2138959855 @default.
- W2885492789 cites W2140343175 @default.
- W2885492789 cites W2142094922 @default.
- W2885492789 cites W2146016283 @default.
- W2885492789 cites W2146680438 @default.
- W2885492789 cites W2147420866 @default.
- W2885492789 cites W2151948621 @default.
- W2885492789 cites W2153382986 @default.
- W2885492789 cites W2157962067 @default.
- W2885492789 cites W2158734599 @default.
- W2885492789 cites W2163958696 @default.
- W2885492789 cites W2164034599 @default.
- W2885492789 cites W2166984633 @default.
- W2885492789 cites W2168631000 @default.
- W2885492789 cites W2168901267 @default.
- W2885492789 cites W2170858024 @default.
- W2885492789 cites W2236482561 @default.
- W2885492789 cites W2259161257 @default.
- W2885492789 cites W2273301812 @default.
- W2885492789 cites W2343063345 @default.
- W2885492789 cites W2414312833 @default.