FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885495225> ?p ?o ?g. }

• W2885495225 endingPage "e0006620" @default.
• W2885495225 startingPage "e0006620" @default.
• W2885495225 abstract "Microbiome studies suggest the presence of an interaction between the human gut microbiome and soil-transmitted helminth. Upon deworming, a complex interaction between the anthelminthic drug, helminths and microbiome composition might occur. To dissect this, we analyse the changes that take place in the gut bacteria profiles in samples from a double blind placebo controlled trial conducted in an area endemic for soil transmitted helminths in Indonesia.Either placebo or albendazole were given every three months for a period of one and a half years. Helminth infection was assessed before and at 3 months after the last treatment round. In 150 subjects, the bacteria were profiled using the 454 pyrosequencing. Statistical analysis was performed cross-sectionally at pre-treatment to assess the effect of infection, and at post-treatment to determine the effect of infection and treatment on microbiome composition using the Dirichlet-multinomial regression model.At a phylum level, at pre-treatment, no difference was seen in microbiome composition in terms of relative abundance between helminth-infected and uninfected subjects and at post-treatment, no differences were found in microbiome composition between albendazole and placebo group. However, in subjects who remained infected, there was a significant difference in the microbiome composition of those who had received albendazole and placebo. This difference was largely attributed to alteration of Bacteroidetes. Albendazole was more effective against Ascaris lumbricoides and hookworms but not against Trichuris trichiura, thus in those who remained infected after receiving albendazole, the helminth composition was dominated by T. trichiura.We found that overall, albendazole does not affect the microbiome composition. However, there is an interaction between treatment and helminths as in subjects who received albendazole and remained infected there was a significant alteration in Bacteroidetes. This helminth-albendazole interaction needs to be studied further to fully grasp the complexity of the effect of deworming on the microbiome.ISRCTN Registy, ISRCTN83830814." @default.
• W2885495225 created "2018-08-22" @default.
• W2885495225 creator A5014550438 @default.
• W2885495225 creator A5024279527 @default.
• W2885495225 creator A5032999324 @default.
• W2885495225 creator A5036900827 @default.
• W2885495225 creator A5073074999 @default.
• W2885495225 creator A5074193742 @default.
• W2885495225 creator A5078174122 @default.
• W2885495225 creator A5085897306 @default.
• W2885495225 date "2018-08-09" @default.
• W2885495225 modified "2023-10-12" @default.
• W2885495225 title "Dynamic changes in human-gut microbiome in relation to a placebo-controlled anthelminthic trial in Indonesia" @default.
• W2885495225 cites W1560923108 @default.
• W2885495225 cites W1805101691 @default.
• W2885495225 cites W1968105193 @default.
• W2885495225 cites W1978100213 @default.
• W2885495225 cites W1983972858 @default.
• W2885495225 cites W2001181252 @default.
• W2885495225 cites W2006234573 @default.
• W2885495225 cites W2011671647 @default.
• W2885495225 cites W2012859165 @default.
• W2885495225 cites W2024544279 @default.
• W2885495225 cites W2028368894 @default.
• W2885495225 cites W2032230795 @default.
• W2885495225 cites W2035742252 @default.
• W2885495225 cites W2049017883 @default.
• W2885495225 cites W2068796307 @default.
• W2885495225 cites W2087292184 @default.
• W2885495225 cites W2087922619 @default.
• W2885495225 cites W2102201378 @default.
• W2885495225 cites W2102687520 @default.
• W2885495225 cites W2121154361 @default.
• W2885495225 cites W2124557952 @default.
• W2885495225 cites W2132721989 @default.
• W2885495225 cites W2134199230 @default.
• W2885495225 cites W2136552678 @default.
• W2885495225 cites W2138947021 @default.
• W2885495225 cites W2149351690 @default.
• W2885495225 cites W2156591001 @default.
• W2885495225 cites W2158300991 @default.
• W2885495225 cites W2158524254 @default.
• W2885495225 cites W2162088497 @default.
• W2885495225 cites W2163903604 @default.
• W2885495225 cites W2167062509 @default.
• W2885495225 cites W2169330513 @default.
• W2885495225 cites W2340637042 @default.
• W2885495225 cites W2404939443 @default.
• W2885495225 cites W2535395017 @default.
• W2885495225 cites W2561337133 @default.
• W2885495225 cites W2604895837 @default.
• W2885495225 cites W2620098478 @default.
• W2885495225 cites W2788177313 @default.
• W2885495225 cites W2791752010 @default.
• W2885495225 cites W3098806227 @default.
• W2885495225 doi "https://doi.org/10.1371/journal.pntd.0006620" @default.
• W2885495225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6084808" @default.
• W2885495225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30091979" @default.
• W2885495225 hasPublicationYear "2018" @default.
• W2885495225 type Work @default.
• W2885495225 sameAs 2885495225 @default.
• W2885495225 citedByCount "38" @default.
• W2885495225 countsByYear W28854952252018 @default.
• W2885495225 countsByYear W28854952252019 @default.
• W2885495225 countsByYear W28854952252020 @default.
• W2885495225 countsByYear W28854952252021 @default.
• W2885495225 countsByYear W28854952252022 @default.
• W2885495225 countsByYear W28854952252023 @default.
• W2885495225 crossrefType "journal-article" @default.
• W2885495225 hasAuthorship W2885495225A5014550438 @default.
• W2885495225 hasAuthorship W2885495225A5024279527 @default.
• W2885495225 hasAuthorship W2885495225A5032999324 @default.
• W2885495225 hasAuthorship W2885495225A5036900827 @default.
• W2885495225 hasAuthorship W2885495225A5073074999 @default.
• W2885495225 hasAuthorship W2885495225A5074193742 @default.
• W2885495225 hasAuthorship W2885495225A5078174122 @default.
• W2885495225 hasAuthorship W2885495225A5085897306 @default.
• W2885495225 hasBestOaLocation W28854952251 @default.
• W2885495225 hasConcept C104317684 @default.
• W2885495225 hasConcept C125009961 @default.
• W2885495225 hasConcept C126322002 @default.
• W2885495225 hasConcept C142724271 @default.
• W2885495225 hasConcept C143121216 @default.
• W2885495225 hasConcept C165901193 @default.
• W2885495225 hasConcept C18903297 @default.
• W2885495225 hasConcept C203014093 @default.
• W2885495225 hasConcept C204787440 @default.
• W2885495225 hasConcept C27081682 @default.
• W2885495225 hasConcept C2776117458 @default.
• W2885495225 hasConcept C2777065887 @default.
• W2885495225 hasConcept C2777364306 @default.
• W2885495225 hasConcept C2777461070 @default.
• W2885495225 hasConcept C2779459945 @default.
• W2885495225 hasConcept C2779786594 @default.
• W2885495225 hasConcept C2908979412 @default.
• W2885495225 hasConcept C42407357 @default.
• W2885495225 hasConcept C54355233 @default.
• W2885495225 hasConcept C60644358 @default.

• next