FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885499983> ?p ?o ?g. }

• W2885499983 endingPage "85" @default.
• W2885499983 startingPage "79" @default.
• W2885499983 abstract "Helicobacter pylori increases reactive oxygen species (ROS) and induces oxidative DNA damage and apoptosis in gastric epithelial cells. DNA damage activates DNA damage response (DDR) which includes ataxia-telangiectasia-mutated (ATM) activation. ATM increases alternative reading frame (ARF) but decreases mouse double minute 2 (Mdm2). Because p53 interacts with Mdm2, H. pylori-induced loss of Mdm2 stabilizes p53 and induces apoptosis. Previous study showed that Korean Red Ginseng extract (KRG) reduces ROS and prevents cell death in H. pylori-infected gastric epithelial cells.We determined whether KRG inhibits apoptosis by suppressing DDRs and apoptotic indices in H. pylori-infected gastric epithelial AGS cells. The infected cells were treated with or without KRG or an ATM kinase inhibitor KU-55933. ROS levels, apoptotic indices (cell death, DNA fragmentation, Bax/Bcl-2 ratio, caspase-3 activity) and DDRs (activation and levels of ATM, checkpoint kinase 2, Mdm2, ARF, and p53) were determined.H. pylori induced apoptosis by increasing apoptotic indices and ROS levels. H. pylori activated DDRs (increased p-ATM, p-checkpoint kinase 2, ARF, p-p53, and p53, but decreased Mdm2) in gastric epithelial cells. KRG reduced ROS and inhibited increase in apoptotic indices and DDRs in H. pylori-infected gastric epithelial cells. KU-55933 suppressed DDRs and apoptosis in H. pylori-infected gastric epithelial cells, similar to KRG.KRG suppressed ATM-mediated DDRs and apoptosis by reducing ROS in H. pylori-infected gastric epithelial cells. Supplementation with KRG may prevent the oxidative stress-mediated gastric impairment associated with H. pylori infection." @default.
• W2885499983 created "2018-08-22" @default.
• W2885499983 creator A5029929216 @default.
• W2885499983 creator A5038069069 @default.
• W2885499983 creator A5087538716 @default.
• W2885499983 date "2020-01-01" @default.
• W2885499983 modified "2023-10-18" @default.
• W2885499983 title "Inhibitory effect of Korean Red Ginseng extract on DNA damage response and apoptosis in Helicobacter pylori–infected gastric epithelial cells" @default.
• W2885499983 cites W1519197898 @default.
• W2885499983 cites W1557508630 @default.
• W2885499983 cites W1560780012 @default.
• W2885499983 cites W1564933160 @default.
• W2885499983 cites W1937607074 @default.
• W2885499983 cites W1973136934 @default.
• W2885499983 cites W1977019550 @default.
• W2885499983 cites W1980616359 @default.
• W2885499983 cites W1986256428 @default.
• W2885499983 cites W1988749598 @default.
• W2885499983 cites W1990304352 @default.
• W2885499983 cites W1995039517 @default.
• W2885499983 cites W1998630067 @default.
• W2885499983 cites W2002475509 @default.
• W2885499983 cites W2005607099 @default.
• W2885499983 cites W2006993711 @default.
• W2885499983 cites W2008797552 @default.
• W2885499983 cites W2019297458 @default.
• W2885499983 cites W2028210102 @default.
• W2885499983 cites W2039463309 @default.
• W2885499983 cites W2039467788 @default.
• W2885499983 cites W2045086385 @default.
• W2885499983 cites W2045752681 @default.
• W2885499983 cites W2050513395 @default.
• W2885499983 cites W2056530510 @default.
• W2885499983 cites W2082979850 @default.
• W2885499983 cites W2089574530 @default.
• W2885499983 cites W2099907467 @default.
• W2885499983 cites W2108638396 @default.
• W2885499983 cites W2111772438 @default.
• W2885499983 cites W2120921507 @default.
• W2885499983 cites W2128100832 @default.
• W2885499983 cites W2131833681 @default.
• W2885499983 cites W2147512361 @default.
• W2885499983 cites W2155640249 @default.
• W2885499983 cites W2200999279 @default.
• W2885499983 cites W2582215963 @default.
• W2885499983 cites W2742313783 @default.
• W2885499983 cites W4212962560 @default.
• W2885499983 cites W4300296976 @default.
• W2885499983 doi "https://doi.org/10.1016/j.jgr.2018.08.003" @default.
• W2885499983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7033323" @default.
• W2885499983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32148392" @default.
• W2885499983 hasPublicationYear "2020" @default.
• W2885499983 type Work @default.
• W2885499983 sameAs 2885499983 @default.
• W2885499983 citedByCount "15" @default.
• W2885499983 countsByYear W28854999832018 @default.
• W2885499983 countsByYear W28854999832020 @default.
• W2885499983 countsByYear W28854999832021 @default.
• W2885499983 countsByYear W28854999832022 @default.
• W2885499983 countsByYear W28854999832023 @default.
• W2885499983 crossrefType "journal-article" @default.
• W2885499983 hasAuthorship W2885499983A5029929216 @default.
• W2885499983 hasAuthorship W2885499983A5038069069 @default.
• W2885499983 hasAuthorship W2885499983A5087538716 @default.
• W2885499983 hasBestOaLocation W28854999831 @default.
• W2885499983 hasConcept C143425029 @default.
• W2885499983 hasConcept C153911025 @default.
• W2885499983 hasConcept C190283241 @default.
• W2885499983 hasConcept C2776409635 @default.
• W2885499983 hasConcept C48349386 @default.
• W2885499983 hasConcept C502942594 @default.
• W2885499983 hasConcept C54355233 @default.
• W2885499983 hasConcept C552990157 @default.
• W2885499983 hasConcept C55493867 @default.
• W2885499983 hasConcept C86803240 @default.
• W2885499983 hasConcept C95444343 @default.
• W2885499983 hasConceptScore W2885499983C143425029 @default.
• W2885499983 hasConceptScore W2885499983C153911025 @default.
• W2885499983 hasConceptScore W2885499983C190283241 @default.
• W2885499983 hasConceptScore W2885499983C2776409635 @default.
• W2885499983 hasConceptScore W2885499983C48349386 @default.
• W2885499983 hasConceptScore W2885499983C502942594 @default.
• W2885499983 hasConceptScore W2885499983C54355233 @default.
• W2885499983 hasConceptScore W2885499983C552990157 @default.
• W2885499983 hasConceptScore W2885499983C55493867 @default.
• W2885499983 hasConceptScore W2885499983C86803240 @default.
• W2885499983 hasConceptScore W2885499983C95444343 @default.
• W2885499983 hasFunder F4320321314 @default.
• W2885499983 hasIssue "1" @default.
• W2885499983 hasLocation W28854999831 @default.
• W2885499983 hasLocation W28854999832 @default.
• W2885499983 hasLocation W28854999833 @default.
• W2885499983 hasLocation W28854999834 @default.
• W2885499983 hasLocation W28854999835 @default.
• W2885499983 hasOpenAccess W2885499983 @default.
• W2885499983 hasPrimaryLocation W28854999831 @default.
• W2885499983 hasRelatedWork W1983889779 @default.
• W2885499983 hasRelatedWork W2028111178 @default.

• next