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- W2885519362 abstract "Objective To observe both clinicopathological and biological features of follicular dendritic cell sarcoma(FDCS) of tonsil. Methods A case of FDCS Was studied by light microscopy and immunohistochemistry and discussed with literature review.Results A 23-year-old Chinese female presented as sore throat for two month.A 2.5 cm tumor in diameter in her left side tonsil was resected.Microscopically,tumor was divided into obscure lobular appearance by fibrous tissue bands.Neoplastic cells were corpulent spindle or oval in shape,with clear cut nuclear membrane and indefinite cells border,which arranged in fascicular,whorled,and story-form patterns.The nuclear was heterogeneous,showing mild to moderate pleomorphism. A few of multinucleated giant cells and Red-Steinberger-like cells could be found.Many small lymphocytes were sparked in background.The tumor cells appeared mediate proliferation activity and mitotic figure(5/10HPF) was easily found.Immunohistochemically,tumor cells were positive for CD21 and CD35 antibodies.Follow-up data showed that the patient was no evidence of recurrence and metastasis 18 month late after operation. Conclusion Oral FDCS very rare.Histopathologically,other spindle cell tumors of oral cavity should be rule out at first,including fibrohistiocytoma,inflammatory myofibroblastoma,myoepithelioma,and the others.Using immunohistochemiscal staining to identify the follicular dendritic cell feature(CD21,CD23,and CD35) may confirm the diagnosis of FDCS.Biologically,FDCS is belongs to low-grade malignant tumor in general, with a high relapse rate and low metastasis percentage.The optimal treatment approach is surgery to resect the tumor completely with negative margin.But for high-grade FDCS,adjuvant therapy should be considered." @default.
- W2885519362 created "2018-08-22" @default.
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- W2885519362 date "2009-01-01" @default.
- W2885519362 modified "2023-09-23" @default.
- W2885519362 title "Follicular dendritic cell sarcoma of the tonsil:a case report and literature review" @default.
- W2885519362 hasPublicationYear "2009" @default.
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