Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885536345> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2885536345 abstract "Identifying molecular targets for hepatocellular carcinoma (HCC) is an urgent need to overcome the treatment failure and death from cancer cell invasion and metastasis. Beta-1,4-galactosyltransferase 1 (B4GALT1) has been documented as the key enzyme in morphogenesis and cellular adhesion, for it adds galactose to N-acetylglucosamine residues of glycoprotein carbohydrate chains; whereas abnormal B4GALT1 expression is associated with tumor progress in many cancers. However, functional roles of B4GALT1 in HCC remains unclear. With clinical correlation, the immunohistochemistry confirmed that lower expression of B4GALT1 in cancer tissue is associated with higher ratio of vascular invasion and worse overall survival. Consistently, stable knockdown of B4GALT1 regarding HCC cell lines promoted cell migration, and invasion; as the overexpressed B4GALT1 inhibited cell migration and invasion of HCC cell lines. Moreover, our data suggested that down-regulated B4GALT1 modified LEL lectin, and interfered hepatocyte growth factor receptor (HGFR), Epidermal growth factor receptor (EGFR), and Axl signaling. Given that, B4GALT1 is sufficient to inversely regulate malignant behaviors of HCC cells with a significant correlation between gene expression and clinical prognosis, implying that B4GALT1 played a crucial role in cancer progress of HCC. Citation Format: Po-Da Chen, Ai-An Chang, Yao-Ming Wu, Min-Chuan Huang. Silencing of B4GALT1 inversely regulates malignant phenotypes of hepatocellular carcinoma cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1402." @default.
- W2885536345 created "2018-08-22" @default.
- W2885536345 creator A5006469117 @default.
- W2885536345 creator A5053641942 @default.
- W2885536345 creator A5066085894 @default.
- W2885536345 creator A5073677542 @default.
- W2885536345 date "2018-07-01" @default.
- W2885536345 modified "2023-09-25" @default.
- W2885536345 title "Abstract 1402: Silencing of B4GALT1 inversely regulates malignant phenotypes of hepatocellular carcinoma cells" @default.
- W2885536345 doi "https://doi.org/10.1158/1538-7445.am2018-1402" @default.
- W2885536345 hasPublicationYear "2018" @default.
- W2885536345 type Work @default.
- W2885536345 sameAs 2885536345 @default.
- W2885536345 citedByCount "0" @default.
- W2885536345 crossrefType "proceedings-article" @default.
- W2885536345 hasAuthorship W2885536345A5006469117 @default.
- W2885536345 hasAuthorship W2885536345A5053641942 @default.
- W2885536345 hasAuthorship W2885536345A5066085894 @default.
- W2885536345 hasAuthorship W2885536345A5073677542 @default.
- W2885536345 hasConcept C104317684 @default.
- W2885536345 hasConcept C119056186 @default.
- W2885536345 hasConcept C121608353 @default.
- W2885536345 hasConcept C173396325 @default.
- W2885536345 hasConcept C203014093 @default.
- W2885536345 hasConcept C204232928 @default.
- W2885536345 hasConcept C2778019345 @default.
- W2885536345 hasConcept C2779013556 @default.
- W2885536345 hasConcept C502942594 @default.
- W2885536345 hasConcept C54355233 @default.
- W2885536345 hasConcept C81885089 @default.
- W2885536345 hasConcept C86803240 @default.
- W2885536345 hasConcept C96232424 @default.
- W2885536345 hasConceptScore W2885536345C104317684 @default.
- W2885536345 hasConceptScore W2885536345C119056186 @default.
- W2885536345 hasConceptScore W2885536345C121608353 @default.
- W2885536345 hasConceptScore W2885536345C173396325 @default.
- W2885536345 hasConceptScore W2885536345C203014093 @default.
- W2885536345 hasConceptScore W2885536345C204232928 @default.
- W2885536345 hasConceptScore W2885536345C2778019345 @default.
- W2885536345 hasConceptScore W2885536345C2779013556 @default.
- W2885536345 hasConceptScore W2885536345C502942594 @default.
- W2885536345 hasConceptScore W2885536345C54355233 @default.
- W2885536345 hasConceptScore W2885536345C81885089 @default.
- W2885536345 hasConceptScore W2885536345C86803240 @default.
- W2885536345 hasConceptScore W2885536345C96232424 @default.
- W2885536345 hasLocation W28855363451 @default.
- W2885536345 hasOpenAccess W2885536345 @default.
- W2885536345 hasPrimaryLocation W28855363451 @default.
- W2885536345 hasRelatedWork W1973329326 @default.
- W2885536345 hasRelatedWork W1975859778 @default.
- W2885536345 hasRelatedWork W2509733117 @default.
- W2885536345 hasRelatedWork W2568845480 @default.
- W2885536345 hasRelatedWork W2763237291 @default.
- W2885536345 hasRelatedWork W2791305333 @default.
- W2885536345 hasRelatedWork W2800551378 @default.
- W2885536345 hasRelatedWork W2995643831 @default.
- W2885536345 hasRelatedWork W3215939181 @default.
- W2885536345 hasRelatedWork W4283771460 @default.
- W2885536345 isParatext "false" @default.
- W2885536345 isRetracted "false" @default.
- W2885536345 magId "2885536345" @default.
- W2885536345 workType "article" @default.