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- W2885539360 endingPage "2310" @default.
- W2885539360 startingPage "2310" @default.
- W2885539360 abstract "Bronchiolitis obliterans syndrome (BOS), caused by lung allograft-derived mesenchymal cells’ abnormal proliferation and extracellular matrix deposition, is the main cause of lung allograft rejection. In this study, a mild one-step ionotropic gelation method was set up to nanoencapsulate the everolimus, a key molecule in allograft organ rejection prevention, into hyaluronic acid-decorated chitosan-based nanoparticles. Rationale was the selective delivery of everolimus into lung allograft-derived mesenchymal cells; these cells are characterized by the CD44-overexpressing feature, and hyaluronic acid has proven to be a natural selective CD44-targeting moiety. The optimal process conditions were established by a design of experiment approach (full factorial design) aiming at the control of the nanoparticle size (≤200 nm), minimizing the size polydispersity (PDI 0.171 ± 0.04), and at the negative ζ potential maximization (−30.9 mV). The everolimus was successfully loaded into hyaluronic acid-decorated chitosan-based nanoparticles (95.94 ± 13.68 μg/100 mg nanoparticles) and in vitro released in 24 h. The hyaluronic acid decoration on the nanoparticles provided targetability to CD44-overexpressing mesenchymal cells isolated from bronchoalveolar lavage of BOS-affected patients. The mesenchymal cells’ growth tests along with the nanoparticles uptake studies, at 37 °C and 4 °C, respectively, demonstrated a clear improvement of everolimus inhibitory activity when it is encapsulated in hyaluronic acid-decorated chitosan-based nanoparticles, ascribable to their active uptake mechanism." @default.
- W2885539360 created "2018-08-22" @default.
- W2885539360 creator A5002453648 @default.
- W2885539360 creator A5010705644 @default.
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- W2885539360 creator A5035127057 @default.
- W2885539360 creator A5050504480 @default.
- W2885539360 creator A5059444134 @default.
- W2885539360 creator A5064069613 @default.
- W2885539360 date "2018-08-07" @default.
- W2885539360 modified "2023-10-01" @default.
- W2885539360 title "Hyaluronic Acid-Decorated Chitosan Nanoparticles for CD44-Targeted Delivery of Everolimus" @default.
- W2885539360 cites W1135720400 @default.
- W2885539360 cites W134164392 @default.
- W2885539360 cites W1582634852 @default.
- W2885539360 cites W1649157390 @default.
- W2885539360 cites W1877301297 @default.
- W2885539360 cites W1971645600 @default.
- W2885539360 cites W1971909186 @default.
- W2885539360 cites W1971915442 @default.
- W2885539360 cites W1972484031 @default.
- W2885539360 cites W1974110587 @default.
- W2885539360 cites W1974889520 @default.
- W2885539360 cites W1979491885 @default.
- W2885539360 cites W1982974605 @default.
- W2885539360 cites W1987169768 @default.
- W2885539360 cites W1994729079 @default.
- W2885539360 cites W1994804221 @default.
- W2885539360 cites W1995817511 @default.
- W2885539360 cites W1999327728 @default.
- W2885539360 cites W2010693773 @default.
- W2885539360 cites W2010860761 @default.
- W2885539360 cites W2013184623 @default.
- W2885539360 cites W2013998409 @default.
- W2885539360 cites W2016049885 @default.
- W2885539360 cites W2019729163 @default.
- W2885539360 cites W2019853172 @default.
- W2885539360 cites W2022117557 @default.
- W2885539360 cites W2023075303 @default.
- W2885539360 cites W2030141620 @default.
- W2885539360 cites W2030669680 @default.
- W2885539360 cites W2034829127 @default.
- W2885539360 cites W2035772234 @default.
- W2885539360 cites W2039149427 @default.
- W2885539360 cites W2040767465 @default.
- W2885539360 cites W2042250873 @default.
- W2885539360 cites W2043420829 @default.
- W2885539360 cites W2046070477 @default.
- W2885539360 cites W2049262810 @default.
- W2885539360 cites W2050644354 @default.
- W2885539360 cites W2056966258 @default.
- W2885539360 cites W2062970882 @default.
- W2885539360 cites W2064404156 @default.
- W2885539360 cites W2069351246 @default.
- W2885539360 cites W2070705082 @default.
- W2885539360 cites W2072454229 @default.
- W2885539360 cites W2073299869 @default.
- W2885539360 cites W2073649604 @default.
- W2885539360 cites W2077236322 @default.
- W2885539360 cites W2077939789 @default.
- W2885539360 cites W2079407952 @default.
- W2885539360 cites W2081743184 @default.
- W2885539360 cites W2083056981 @default.
- W2885539360 cites W2089912700 @default.
- W2885539360 cites W2098509559 @default.
- W2885539360 cites W2106169256 @default.
- W2885539360 cites W2108565052 @default.
- W2885539360 cites W2109352233 @default.
- W2885539360 cites W2114918609 @default.
- W2885539360 cites W2115339164 @default.
- W2885539360 cites W2135215701 @default.
- W2885539360 cites W2150504395 @default.
- W2885539360 cites W2157344438 @default.
- W2885539360 cites W2162097998 @default.
- W2885539360 cites W2164325854 @default.
- W2885539360 cites W2168133196 @default.
- W2885539360 cites W2204675003 @default.
- W2885539360 cites W2293305692 @default.
- W2885539360 cites W2324005683 @default.
- W2885539360 cites W2326413411 @default.
- W2885539360 cites W2328820789 @default.
- W2885539360 cites W2336858001 @default.
- W2885539360 cites W2341363697 @default.
- W2885539360 cites W2396747981 @default.
- W2885539360 cites W2406288281 @default.
- W2885539360 cites W2517507421 @default.
- W2885539360 cites W2520472484 @default.
- W2885539360 cites W2539213514 @default.
- W2885539360 cites W2613204076 @default.
- W2885539360 cites W2622938690 @default.
- W2885539360 cites W2761800946 @default.
- W2885539360 cites W2775405622 @default.
- W2885539360 cites W2784306082 @default.
- W2885539360 cites W2789457987 @default.
- W2885539360 cites W2792790716 @default.
- W2885539360 cites W4253779214 @default.
- W2885539360 doi "https://doi.org/10.3390/ijms19082310" @default.
- W2885539360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6121415" @default.