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- W2885603277 abstract "Photoacoustic imaging (PAI) is a fast growing deep-tissue imaging modality. However, light scattering and absorption in biological tissues limit imaging depth. Short near-infrared wavelengths (650 to 950 nm) are widely used for PAI. Using longer near-infrared wavelengths reduces scattering. We demonstrate deep-tissue contrast-enhanced in vivo photoacoustic imaging at a wavelength of 1064 nm. An ultranarrow bandgap semiconducting polymer poly (thienoisoindigo-alt-diketopyrrolopyrrole) (denoted as PIGD) is designed and demonstrated for imaging at 1064 nm. By embedding colloidal nanoparticles (NPs) of PIGD in chicken-breast tissue, an imaging depth of ∼5 cm is achieved. Intravenous injection of PIGD NPs in living rats showed brain vascular images with ∼2 times higher contrast compared with the brain vascular images without any contrast agent. Thus, PIGD NPs as an NIR-II contrast agent opens new opportunities for both preclinical and clinical imaging of deep tissues with enhanced contrast." @default.
- W2885603277 created "2018-08-22" @default.
- W2885603277 creator A5090539557 @default.
- W2885603277 date "2018-08-17" @default.
- W2885603277 modified "2023-09-25" @default.
- W2885603277 title "Contrast-enhanced photoacoustic imaging in the second near-infrared window using semiconducting polymer nanoparticles" @default.
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- W2885603277 doi "https://doi.org/10.1117/1.jbo.24.3.031002" @default.
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