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- W2885609705 abstract "Background and Purpose: Ischemic stroke is a sexually dimorphic disease. Events that occur during pregnancy can have lasting implications on both the mother and fetus for decades after parturition. In particular, fetomaternal microchimerism, the bidirectional exchange and persistence of cells between a pregnant female and her fetus, has been shown to play a role in various disease pathologies but has not been well studied in the brain. We hypothesized that microchimeric cells (MCs) home to sites of injury as part of the immune response to stroke and display a stem cell phenotype with potential to aid in repair. Methods: C57Bl/6 mice were bred with GFP transgenic mice using specific mating paradigms to generate fetal and maternal microchimeras. Young 10-12 week old maternal-microchimeric mice and 12-14 week old parous fetal-microchimeric mice were subject to a 90 min MCAO or sham surgery and sacrificed at 72hr or 30 day post-reperfusion (n=10). Blood, bone marrow (BM), and brain tissue were analyzed by co-..." @default.
- W2885609705 created "2018-08-22" @default.
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- W2885609705 date "2014-02-01" @default.
- W2885609705 modified "2023-09-24" @default.
- W2885609705 title "Abstract W MP43: Fetal and Maternal Microchimeric Responses to Ischemic Stroke" @default.
- W2885609705 hasPublicationYear "2014" @default.
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