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• W2885642231 abstract "Nanosizing has become a well-established and frequently used formulation approach for poorly soluble compounds during preclinical work. Extensive research has generated many different approaches to produce drug nanoparticles. In the present chapter, wet milling is described as one of four approaches in a preclinical toolbox. Regarding crystalline drug nanoparticles, the milling approach is mainly used for high doses and large quantities, while a precipitation approach is used for smaller amounts (approximately some milliliters) up to about 10 mM. Two different main approaches are described for amorphous drug nanoparticles, one appropriate for low-dose animal studies and another for larger-scale toxicological studies. Three case studies are presented. In the first one, nanocrystals used for oral administration resulted in improved in vivo exposure compared with larger particles suffering from dissolution rate limitations. In the two other case studies presented, amorphous drug nanoparticles resulted in superior oral bioavailability compared with nanocrystals of the same compound. Drug nanosuspensions add tremendous dosing flexibility, rapid manufacturing possibilities, and the opportunity to use all conceivable administration routes." @default.
• W2885642231 created "2018-08-22" @default.
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• W2885642231 date "2018-08-03" @default.
• W2885642231 modified "2023-10-16" @default.
• W2885642231 title "A Practical Guide for the Preparation of Drug Nanosuspensions for Preclinical Studies: Including <i>In Vivo</i> Case Studies" @default.
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• W2885642231 doi "https://doi.org/10.1002/9783527801756.ch13" @default.
• W2885642231 hasPublicationYear "2018" @default.
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