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- W2885650843 abstract "Cancer immunotherapies have shown substantial clinical activity for a subset of patients with epithelial cancers. Still, technological platforms to study cancer T-cell interactions for individual patients and understand determinants of responsiveness are presently lacking. Here, we establish and validate a platform to induce and analyze tumor-specific T cell responses to epithelial cancers in a personalized manner. We demonstrate that co-cultures of autologous tumor organoids and peripheral blood lymphocytes can be used to enrich tumor-reactive T cells from peripheral blood of patients with mismatch repair-deficient colorectal cancer and non-small-cell lung cancer. Furthermore, we demonstrate that these T cells can be used to assess the efficiency of killing of matched tumor organoids. This platform provides an unbiased strategy for the isolation of tumor-reactive T cells and provides a means by which to assess the sensitivity of tumor cells to T cell-mediated attack at the level of the individual patient." @default.
- W2885650843 created "2018-08-22" @default.
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- W2885650843 date "2018-09-01" @default.
- W2885650843 modified "2023-10-14" @default.
- W2885650843 title "Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids" @default.
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- W2885650843 doi "https://doi.org/10.1016/j.cell.2018.07.009" @default.
- W2885650843 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6558289" @default.
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