Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885654702> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2885654702 abstract "Our recent studies showed significant antiproliferative capacity of newly synthesized N-9-sulfonylpyrimidine derivatives on human carcinoma, lymphoma, and leukemia cells. These derivatives behave as antimetabolites exploiting cellular metabolism to induce cytotoxicity in treated tumors’ cells [1-3]. Based on previously obtained results on N-9-sulfonylpyrimidine derivatives, a new series of N-9-sulfonylpurine derivatives were synthesized and tested on biological potential. The aim of this study was to determine if measured antitumor activity of N-9-sulfonylpurine derivatives is linked with ROS accumulation and mitochondrial membrane destabilization in human cervix adenocarcinoma (HeLa), human chronic myelogenous leukemia (K562) and human Burkitt’s lymphoma (Raji) cells. Changes in the mitochondrial membrane potential (∆Ψm) of tested compounds were determined by flow cytometry, measuring fluorescence of JC-1 dye in tumor cells after 24 hours of treatment. Intracellular accumulation of ROS was determined after 1 hour in cells exposed to N-9-sulfonylpurine derivatives by flow cytometry as well. Tested derivatives induced increased accumulation of ROS and mitochondrial disruption in more than 80% of HeLa and Raji cells. The effect of tested derivatives on K562 cells is reflected by the change of mitochondrial potential in more than 70% with slightly reduced accumulation of ROS. Based on obtained results we can conclude that newly synthesized N-9-sulfonylpurine derivatives are good candidates for further antitumor studies." @default.
- W2885654702 created "2018-08-22" @default.
- W2885654702 creator A5007494352 @default.
- W2885654702 creator A5008061001 @default.
- W2885654702 creator A5034833302 @default.
- W2885654702 creator A5070556166 @default.
- W2885654702 creator A5091000778 @default.
- W2885654702 date "2018-08-01" @default.
- W2885654702 modified "2023-09-25" @default.
- W2885654702 title "New N-9- sulfonylpurine derivatives induce changes in mitochondrial function and ROS accumulation in carcinoma and leukemia cells in vitro" @default.
- W2885654702 doi "https://doi.org/10.1016/j.freeradbiomed.2018.05.041" @default.
- W2885654702 hasPublicationYear "2018" @default.
- W2885654702 type Work @default.
- W2885654702 sameAs 2885654702 @default.
- W2885654702 citedByCount "0" @default.
- W2885654702 crossrefType "journal-article" @default.
- W2885654702 hasAuthorship W2885654702A5007494352 @default.
- W2885654702 hasAuthorship W2885654702A5008061001 @default.
- W2885654702 hasAuthorship W2885654702A5034833302 @default.
- W2885654702 hasAuthorship W2885654702A5070556166 @default.
- W2885654702 hasAuthorship W2885654702A5091000778 @default.
- W2885654702 hasConcept C109316439 @default.
- W2885654702 hasConcept C153911025 @default.
- W2885654702 hasConcept C16232356 @default.
- W2885654702 hasConcept C171122931 @default.
- W2885654702 hasConcept C185592680 @default.
- W2885654702 hasConcept C190283241 @default.
- W2885654702 hasConcept C202751555 @default.
- W2885654702 hasConcept C203014093 @default.
- W2885654702 hasConcept C2776960273 @default.
- W2885654702 hasConcept C2777366897 @default.
- W2885654702 hasConcept C2778461978 @default.
- W2885654702 hasConcept C28859421 @default.
- W2885654702 hasConcept C502942594 @default.
- W2885654702 hasConcept C553184892 @default.
- W2885654702 hasConcept C55493867 @default.
- W2885654702 hasConcept C86803240 @default.
- W2885654702 hasConceptScore W2885654702C109316439 @default.
- W2885654702 hasConceptScore W2885654702C153911025 @default.
- W2885654702 hasConceptScore W2885654702C16232356 @default.
- W2885654702 hasConceptScore W2885654702C171122931 @default.
- W2885654702 hasConceptScore W2885654702C185592680 @default.
- W2885654702 hasConceptScore W2885654702C190283241 @default.
- W2885654702 hasConceptScore W2885654702C202751555 @default.
- W2885654702 hasConceptScore W2885654702C203014093 @default.
- W2885654702 hasConceptScore W2885654702C2776960273 @default.
- W2885654702 hasConceptScore W2885654702C2777366897 @default.
- W2885654702 hasConceptScore W2885654702C2778461978 @default.
- W2885654702 hasConceptScore W2885654702C28859421 @default.
- W2885654702 hasConceptScore W2885654702C502942594 @default.
- W2885654702 hasConceptScore W2885654702C553184892 @default.
- W2885654702 hasConceptScore W2885654702C55493867 @default.
- W2885654702 hasConceptScore W2885654702C86803240 @default.
- W2885654702 hasLocation W28856547021 @default.
- W2885654702 hasOpenAccess W2885654702 @default.
- W2885654702 hasPrimaryLocation W28856547021 @default.
- W2885654702 hasRelatedWork W2136658115 @default.
- W2885654702 hasRelatedWork W2138053279 @default.
- W2885654702 hasRelatedWork W2289225678 @default.
- W2885654702 hasRelatedWork W2335858268 @default.
- W2885654702 hasRelatedWork W2377556411 @default.
- W2885654702 hasRelatedWork W2392459289 @default.
- W2885654702 hasRelatedWork W2794257693 @default.
- W2885654702 hasRelatedWork W2885654702 @default.
- W2885654702 hasRelatedWork W2949150358 @default.
- W2885654702 hasRelatedWork W2977835618 @default.
- W2885654702 isParatext "false" @default.
- W2885654702 isRetracted "false" @default.
- W2885654702 magId "2885654702" @default.
- W2885654702 workType "article" @default.