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- W2885655350 endingPage "2396" @default.
- W2885655350 startingPage "2396" @default.
- W2885655350 abstract "The mammalian target of rapamycin (mTOR) is a central processor of intra- and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival. Strong evidences have indicated that mTOR dysregulation is deeply implicated in leukemogenesis. This has led to growing interest in the development of modulators of its activity for leukemia treatment. This review intends to provide an outline of the principal biological and molecular functions of mTOR. We summarize the current understanding of how mTOR interacts with microRNAs, with components of cell metabolism, and with controllers of apoptotic machinery. Lastly, from a clinical/translational perspective, we recapitulate the therapeutic results in leukemia, obtained by using mTOR inhibitors as single agents and in combination with other compounds." @default.
- W2885655350 created "2018-08-22" @default.
- W2885655350 creator A5000262370 @default.
- W2885655350 creator A5001112515 @default.
- W2885655350 creator A5021039346 @default.
- W2885655350 creator A5054794378 @default.
- W2885655350 creator A5067656597 @default.
- W2885655350 creator A5070155938 @default.
- W2885655350 date "2018-08-14" @default.
- W2885655350 modified "2023-10-16" @default.
- W2885655350 title "Biological Aspects of mTOR in Leukemia" @default.
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